Posted by admin on Feb 29, 2020 in |
Periodontitis is a group of inflammatory pathological conditions involving periodontal ligaments and supporting alveolar bone which may result in the degeneration of supporting structures of teeth ultimately leading to tooth loss. Present research work is focused on the formulation, optimization and evaluation of chitosan microspheres and chitosan- hydroxyapatite biocomposite microspheres to have controlled release of herbal drug quercetin, of which anti-microbial, anti-inflammatory and wound healing properties are well proven. Mucoadhesive chitosan would retain the drug-loaded microspheres at the affected site and hydroxyapatite used in its combination would improve mechanical strength, osteoconductivity and sustain the release of the drug. Microspheres were formulated by solvent-free precipitation technique using the alkaline solution (NaOH solution). These microspheres were optimized using 32 factorial design using design expert software. Optimized chitosan microspheres (QC5) and chitosan-hydroxyapatite microspheres (QCH5) were characterized for surface morphology by SEM and were found to be spherical with a particle size of 5.56 µm and 7.22 µm and entrapment efficiency of 80.74 and 82.97% respectively. The entrapment of drug in microspheres was...
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Posted by admin on Feb 29, 2020 in |
A sensitive and robust gas chromatography with a flame ionization detector method was developed for the quantification of epichlorohydrin in the linezolid drug substance and validated using guidelines as mentioned in ICH Q2 (R1). Epichlorohydrin was separated on CP-Volamine stationary phase (length 60 m, diameter 0.32 mm, particle size 5 µ) in linear thermal programming using dichloromethane as a diluent, at a constant flow rate of 2 ml/min. Column oven temperature maintained initiated at 90 ºC and raised to temperature 230 ºC with run time 25 min. Epichlorohydrin showed linearity from 5.12 ppm to 30 ppm concentration range. The method has satisfactory precision and accuracy. Limit of detection and limit of quantification were found as 2.03 ppm and 5.12 ppm, respectively. The epichlorohydrin peak has been well resolved and its specificity has been demonstrated. The method developed and validated for estimating epichlorohydrin in linezolid drug molecule is easy and simple to adopt in any pharmaceutical...
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Posted by admin on Feb 29, 2020 in |
Background: Zingiber officinalis known as ginger, under the family Zingiberaceae, is a popular food spice and occupies an important place in Ayurvedic and traditional medicine. Its rhizome is used as antioxidative, carminative and for chronic diseases. Aims: Study indicated the curative effects of methanolic extract of ginger on severe exercise-induced oxidative damage in vital organs. Materials and Methods: Oxidative stress was established in male rat by forced swimming in an acrylic plastic pool filled with water. The total duration of 8 h per day including rest was allowed for both the treated and untreated forced swimming group of animals. Oxidative stress has been observed by monitoring of SOD, CAT, GST and Px activities along with quantification of TBARS and CD levels in liver, cerebrum, testis, and plasma. Whether the applied dose has toxicity if any, general body weight parameter was assessed. Results: Results indicate that SOD, CAT, GST and Px activities were decreased along with increase in levels of TBARS and CD in aforesaid tissues significantly in forced swimming...
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Posted by admin on Feb 29, 2020 in |
Bilayer tablet is a new era for the successful development of controlled release formulation along with various features to provide a way of the successful drug delivery system. Bilayer tablets can be a primary option to avoid chemical incompatibilities between API by physical separation and to enable the development of different drug release profiles. The bi-layered tablet is a very different aspect of anti-inflammatory and analgesic. The purpose of this study was to develop and evaluate bilayered tablets of curcumin for the effective treatment of inflammation. The Immediate-release layer was prepared by using superdisintegrants- SSG and binder used xantham gum and the sustained release layer was prepared by using hydrophilic polymer like HPMC K 100 and PVP. Before the preparation of the tablets, all the pre-formulation parameters were checked and the tablet of curcumin were prepared by direct compression method and was evaluated for physical characteristics like hardness, weight variation, drug content and friability. In-vitro release of drug was performed USP type I dissolution test apparatus using 0.1N HCl...
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Posted by admin on Feb 29, 2020 in |
Introduction: Hypertension, is a global public health issue. It is a significant contributor to rising morbidity and mortality because of its associations with cardiovascular, renal and cerebrovascular complications. Given the prevalence and impact of the disease on health care a drug utilization study becomes essential to determine the current drug utilization pattern. Materials and Methods: 127 patients of hypertension coming to the OPD of medicine of King George’s Medical University were enrolled in the study after screening and giving consent. The data from the prescription of the drugs were recorded in pre-specified case record forms and analyzed for drug utilization parameters. Results: The average number of drugs encountered per prescription was 4. Whereas prescriptions with the generic name were 38% and drugs from an essential drug list were found to be 74%. The most commonly prescribed antihypertensive group was calcium channel blocker (25.1%) in monotherapy followed by angiotensin receptor blocker (21.2%). In combination therapy, the most commonly prescribed combination was found to be calcium channel blocker + angiotensin receptor...
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