Posted by admin on Feb 29, 2020 in |
Marine algae are one of the largest producers of biomass in the marine environment. They produce a wide variety of chemically active metabolites in their surroundings, potentially as an aid to protect themselves against the other settling organisms. These seaweeds are an immense source of bioactive molecules for the exploration of novel drugs. The present investigation deals with the screening of phytochemical composition, fatty acid composition and antioxidant activity of the green edible seaweed Caulerpa lentillifera (Family: Caulerpaceae) (TSN: 6973 & APHIA ID: 211475). The seaweed was collected from Mandapam Coast, Tamil Nadu, different solvents were used for the preparation of seaweed extract. The Phytochemical constituents of seaweeds, such as carbohydrate, protein, tannins, phytosterols, glycosides, alkaloids, flavonoids, diterpenes, resins and saponins of C. lentillifera were analyzed using standard methods. Fatty acid profile was investigated using Gas chromatography Mass spectrometry (GC-MS). Various fatty acid components are analyzed using GC-MS and nearly 35 components were recorded. In the present investigation, the in-vitro analysis of antioxidant property has been confirmed. From this...
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Posted by admin on Feb 29, 2020 in |
Being exposed to a number of heavy metals in the environment, humans are suffering from various health problems. Cadmium and arsenic are both priority hazardous substances and carcinogens. Environmental co-exposure to these heavy metals is also an important consideration and most experiments with laboratory animals investigate only one heavy metal. In the present study albino rats were exposed to both the heavy metals alone and in combination in 5 groups and the 6th group was of control. Animals were treated for 30 days and 60 days with the lower doses of NaAsO2 (4.3 mg/ks b. wt.) in group B and CdCl2 (2.6 mg/kg b. wt.) in group D and higher dose of NaAsO2 (8.6 mg/ks b. wt.) in group C and CdCl2 (5.2 mg/kg b. wt.) in group E. A combination dose of CdCl2 (2.6 mg/kg b. wt.) and NaAsO2 (4.3 mg/ks b. wt.) was given to another group F of experimental animals. In 30 days, intoxicated animal groups the weights of the kidney, brain and heart increased and...
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Posted by admin on Feb 29, 2020 in |
In the present work, temperature/pH-sensitive copolymer beads of chitosan (CS) coated sodium alginate/xanthan gum grafted N, N’-methylenediacrylamide have been synthesized by free radical polymerization in an atmosphere of nitrogen using AIBN/Fe2+ redox pair initiator and Tetramethylethylenediamine (TEMED) as a catalyst followed by simple ionotropic gelation technique. These beads were characterized by Fourier transform infrared (FTIR) spectroscopy, Differential scanning calorimetry (DSC), Field emission scanning electron microscopy (FESEM) Energy-dispersive X-ray spectra (EDS) and X-ray diffraction measurements (X-RD). DSC and X-RD studies reveal the molecular dispersion of Chlorthalidone (CT) drugs. Swelling and drug release behaviors of these beads were investigated in simulated intestinal fluid (pH 7.4) and gastric fluid (pH 2.0) at 37 ºC. Results illustrated that both the swelling and degradation of the optimized beads were influenced by the pH of the test medium, which might be suitable for intestinal drug delivery. The release mechanism was analyzed by fitting the release data into the Korsmeyer-Peppas...
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Posted by admin on Feb 29, 2020 in |
Floating drug delivery system comes with the advantage of sustained release of drugs over a prolonged period of time thereby maximizing the oral absorption of drugs with narrow absorption window, it overcomes the challenges of conventional oral drug delivery system. The aim of the present work was to develop a novel floating in-situ gelling system for sustained drug delivery of Clarithromycin for stomach ulcer. The in-situ gelling system were prepared by dissolving different concentrations of gelling polymers like sodium alginate, gellan gum in deionized water at 70 °C. After cooling to 40 °C fixed amount of drug, CaCO3 and released retardant polymer xanthan gum were dispersed with continuous stirring. All formulations showed pH in the range of 6.72 to 7.25, drug content was found to be in the range of 86.66% to 96.66%, floating lag time was <2 min, duration of floating was >12 h for all the formulations. It was observed that viscosity of solution increases with an increase in polymer concentration. In-vitro drug release was found to...
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Posted by admin on Feb 29, 2020 in |
A stability-indicating RP-HPLC method for the simultaneous determination of emtricitabine (EMT), tenofovir (TNF), cobicistat (COB) and elvitegravir (ELV) in solid dosage forms. The waters 2695, High-Performance Liquid Chromatographic system with column kromasil C18, 250 × 4.6 mm, 5 µ. The detector used is PDA detector at 288 nm. The mobile phase used in this method is pH-3.5 phosphate buffer and acetonitrile in the ratio of 60:40% V/V. Flow rate used for this proposed method is 1.0 ml/min. The retention times observed are 2.304 min, 2.691 min, 3.185 min and 4.537 min for emtricitabine, tenofovir, cobicistat, and elvitegravir respectively. The linearity calculated was found to be within the range. The % recoveries for EMT, TNF, COB and ELV were within the acceptance criteria. These drugs were found to be stable at forced degradation studies and results are within the limits. The proposed method can be used for the quality control of the combination in the pharmaceutical dosage...
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