Posted by admin on Feb 29, 2020 in |
Silica lipid-hybrid formulations have gained an increased interest in recent times as a means to enhance the solubility as well as dissolution of poorly water-soluble lipophilic drugs. The objective of the present investigation was to design and optimize silica lipid hybrid particles of Canagliflozin to improve its solubility. Canagliflozin is an antidiabetic drug used to improve glycaemic control in people with type 2 diabetes. In this study, we have fabricated a Solid-State Lipid-Based Oral Drug Delivery System as CNZ SLH with liquid lipids like Miglyol 812, Labrasol and Acrysol el 135. Sylloid 244 FP grade highly porous silica was used as adsorbent. The interaction of CNZ-SLH particles was studied using X-ray powder diffraction (PXRD), Differential Scanning Calorimetry (DSC) and FTIR spectroscopy. CNZ-SLH particles prepared with Miglyol and Labrasol enhanced the solubility of CNZ by 19.67 fold. Optimized SLH particles formulated as a tablet shows faster drug release than the marketed formulation of CNZ Invokana. Silica lipid hybrid particles can be a cost-effective method to formulate drugs with poor...
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Posted by admin on Jan 31, 2020 in |
Diabetes is a metabolic disorder of carbohydrate, fat and protein metabolism characterized by increased fasting and post prandial blood sugar levels. Diabetes is the most common cause of progressive kidney failure leading to dialysis or transplantation. Nephropathy is reported to develop in 30-40% of patients with diabetes and has become a leading cause of end-stage renal failure worldwide. The various parts of Euphorbia antiquorum have been associated with a number of pharmacological activities which are cytotoxic, hepato-protective and antioxidant. The juice of the plant is acrid, anti-inflammatory, purgative and is useful in rheumatism, dropsy, gout, neuropathy, deafness, cough. The aim of the study was to evaluate the effects of Euphorbia antiquorum on alloxan induced diabetic nephropathy in Wistar rats. Experimental diabetic nephropathy was induced by a single intraperitoneal (i.p) administration of alloxan 120 mg/kg body weight (b.w.). Wistar rats were randomly divided into normal control, diabetic control, diabetic control with standard drug and diabetic treated with ethanolic extract of Euphorbia antiquorum at 200 and 400 mg/kg doses respectively. The...
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Posted by admin on Jan 31, 2020 in |
A new analytical method has been developed for the simultaneous estimation of Telmisartan and Hydrochlorothiazide in their pure and pharmaceutical dosage forms by using Fourier Transform Infrared (FTIR) Spectroscopy. This method involves the extraction of Telmisartan and Hydrochlorothiazide from tablets using chloroform and direct measurement in liquid phase mode using reduced path length cell. The spectra were measured in absorbance mode, equipment was configured to collect spectra at 8 cm-1 resolution, and the spectra were collected between 4000 cm-1 and 450 cm-1. The infrared spectra showed different peaks with baseline correction, among which intense, clear and proportionate peaks were selected at 3411 cm-1, and 1309 cm-1 corresponding to the N-H group and asymmetric SO2 group for Telmisartan and Hydrochlorothiazide respectively for quantitative estimation. Beer-Lambert’s law was obeyed over the concentration range of 50-250 μg/ml for Telmisartan and 25-125 μg/ml for Hydrochlorothiazide. All the results were found to be within the limits. The results obtained were compared statistically with that of HPLC by t-test, which indicated no significant difference between...
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Posted by admin on Jan 31, 2020 in |
The present investigation deals with the development of duloxetine ethosome then loading into the transdermal patch to impart lower drug side effect, enhanced bioavailability, avoiding first-pass metabolism. 32 factorial design was applied to optimize the formulation. Ethanol (X1) and Phospholipid (X2) were taken as independent variable, Responses are vesicle size (Y2), entrapment efficiency (Y1). Optimum desirability was identified and, an optimized formulation was prepared, characterized and loaded into transdermal patch. The transdermal patch was evaluated for drug content, thickness, folding endurance. Ex-vivo permeation study for the prepared patch was conducted and, the permeation parameters and drug permeation mechanism were identified. The percent of alcohol was significantly affecting all the studied responses while the other factors and their interaction effects were varied in their effects on each response. The optimized ethosomes formulation showed observed values for Y2, Y1 of 161 nm and 98.79% respectively. Ex-vivo permeation of films loaded with optimized ethosomal formulation was superior to that of the corresponding pure drug transdermal...
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Posted by admin on Jan 31, 2020 in |
Morinda citrifolia (L.) is an important medicinal plant belonging to the family Rubiaceae and commonly known as “Noni” in Tamil was highly distributed in South India. The aim of this research is to understand the concept and techniques of anatomical and histochemical localization of secondary metabolites in Morinda citrifolia (L.) as well as take part in the standardization of herbal medicine. Initially the morphological observations were determined by using simple microscope. The shape of leaf, fruit, odor and type of flower were determined. The present study investigated the leaf anatomical characterization of upper and lower epidermis of Noni plant and also characterized the petiole and lamina of leaf. Finally, this study also explained the histochemical localization of various primary and secondary metabolites of stem of Morinda citrifolia was carried out with the aim of contributing to its quality control in herbal industries. The results of this study could be useful for correct identification of the plant species and also for the determination of the authenticity of the drug in...
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