Posted by admin on Jan 31, 2020 in |
Ammoniacum gum is traditionally used as an expectorant, stimulant, antispasmodic, catarrh, asthma, chronic bronchitis, and enlargement of liver and spleen in Medicine. The Soxhlet extraction of the oleo gum resin of D. ammoniacum was carried out with organic solvents including hexane, dichloromethane, chloroform, ethyl acetate, and methanol. The screening of the anti-alzheimer activity of the extracts was measured by acetylcholinesterase (AChE) inhibitory activity, and the hexane (IC50 = 32.34 μg/ml) and chloroform (IC50 = 43.5 μg/ml) extract performed highest activity. A profiling experiment of the chloroform extract conducted by LC-MS and literature resources suggested six potential biologically active compounds including doremone A (1), kopetdaghin E (2), dshamirone (3), kopetdaghin D (4), kopetdaghin C (5), and ammodoremine (6). To confirm the responsibility of these compounds for the observed AChE inhibitory activity, the molecular docking studies of these compounds were performed with AChE enzyme which indicated that these compounds show higher AChE inhibitory activity than galantamine as positive control. The molecular docking study was carried out using...
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Posted by admin on Jan 31, 2020 in |
The global burden of CVD is rising due to its increasing prevalence in lower- and middle-income countries where 80% of all global CVD-related deaths occur. Common significant risk factors for dyslipidemia included obesity, diabetes, and dysglycemia. The present study was aimed to investigate the potential antihyperlipidemic activity of ethanolic leaf extract of Bauhinia acuminata in atherogenic diet-induced rats. Preliminary phytochemical screening showed the presence of flavonoids, alkaloids, steroids, terpenoids. Acute toxicity study was performed on the rats using OECD Guideline no. 423 and the maximum safe dose was found to be 5000 mg/kg. Animals were grouped into normal control (Group-I), disease control (Group-II), standard group (Group-III) received Standard drug Atorvastatin 10 mg/kg, and test group (Group-IV) received ethanolic extract of the plant with doses 200 mg/kg and 400 mg/kg. The study was conducted for 30 days and hyperlipidemia induced using atherogenic diet. Statistical analysis was performed using Graph Pad Prism and the values are expressed as mean ± SD values. Bodyweight changes were observed every day upon Induction of...
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Posted by admin on Jan 31, 2020 in |
Niosome is one of the synthetic nanoparticles which often is used for drug delivery and cosmetic industry. The aim of this study was to prepare niosomes encapsulated with KT2 and RT2. KT2 and RT2 are antimicrobial and anticancer peptides derived from crocodile leukocyte extract. Niosomes encapsulated with KT2 and RT2 were prepared by thin-film hydration technique, and peptide encapsulation efficiency was evaluated. Niosome particle size, size distribution, and surface morphology were also studied. The results show that KT2 and RT2 were successfully loaded in the formulations with encapsulation efficiencies of 70.9 ± 0.9% and 59.6 ± 3.4%, respectively. The mean particle size and zeta potential of KT2 and RT2 encapsulated niosomes were 9.3 ± 1.13 µm and – 57.39 ± 2.53 mV and 9.1 ± 0.03 µm and – 50.91 ± 2.28 mV, respectively. Niosomes had spherical shapes with rough surfaces. Niosomes coated with hydroxypropyl methylcellulose phthalate (HPMCP) were evaluated for pH stability. At pH 1.2 and 4.5, the peptide-encapsulated niosomes were stable. In conclusion, these peptide-encapsulated niosomes have...
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Posted by admin on Jan 31, 2020 in |
Objective: Lepidium sativum (Garden cress) is traditionally an important plant with a wide range of activities from the ages. Ample literature about its biological activities, motivate us to evaluate the total flavonoids content and to screen the nootropic activity in mice. Methods: Ethanolic extract was prepared from the seeds of Lepidium sativum using ethanol (70% v/v) and total flavonoids content was estimated by using Zhishen method. The ethanolic extract was screened for its acute toxicity and nootropic activity by elevated plus maze (EPM) and morris water maze (MWM) test in mice. Results: The results showed that the ethanolic seed extract of the plant is having a good amount of flavonoids (17.54 ± 47 of gram equivalence of rutin at 510 nm) and also exhibited significant increase in memory and learning abilities. Conclusion: To conclude, the flavonoids that are present in the ethanolic extract may be responsible for the exhibited activity and it is regarded as safe to administer to the animals. Moreover, further studies are necessary to explore its...
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Posted by admin on Jan 31, 2020 in |
Fossil fuels are significantly depleted nowadays due to excess utilization. Therefore, it is always better to find alternatives to produce eco-friendly fuels. This paper deals with the production of biodiesel from agro-industrial waste such as young coconut husk, custard apple seeds and broiler chicken skin. Lipids were isolated from the substrates using the modified Bligh and Dyer method and transesterification was conducted to the isolated lipids in an inert condition to produce biodiesel. Obtained biodiesel was characterized by Gas Chromatography-Mass Spectroscopy (GC-MS) and confirmation of esters was done using Fourier Transform Infrared (FTIR). This study encourages the production of biodiesel from waste plant and animal...
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