Posted by admin on Jan 31, 2020 in |
Large-leaf gentian herb is a promising source of biologically active substances, which is actively used in the traditional medicine of many countries. It contains flavonoids, iridoids, secoiridoids, polysaccharides, xanthones with a wide spectrum of pharmacological activity. The aim of the research was to establish a procedure for identification of large-leaved gentian (Gentiana macrophylla Pall.) using thin-layer chromatography (TLC). In order to identify both hydrophilic and hydrophobic compounds in extracts from the plant two mobile phases were proposed which allow distinguishing specific zones by their color and relative position. Validation of developed procedure was carried out in terms of specificity and chromatographic system suitability. The specificity of the procedure was assessed by matching of TLC profiles for all studied samples. It was found that the main zones on the chromatograms are matching. Thus, chromatographic characteristics of large leaf gentian aerial parts were established for the first time using validated TLC procedure. The results of the study can be used for standardization of large-leaved gentian...
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Posted by admin on Jan 31, 2020 in |
Introduction: Medicinal plants have always played a major role in primary health care system since time immemorial. Sacred natural sites is the prime place to encompass large medicinal plant with wide range of natural resources. It potentially conserves plant biodiversity with inclusion of sacred places and sacred water bodies. Apart from social and religious importance it, regulate air and water quality of environment. The purpose of this study was to document the floristic diversity and traditional approaches towards the ethnomedicinal plants of Sacred Natural Sites of Panchkoshi Pilgrimage of Varanasi district, Uttar Pradesh India. Methods: An ethnobotanical survey was conducted from May 2016 to April 2018. The information collected through open-ended and semi-structured questionnaire and data were analyzed through Informant consensus factor (ICF). Results: During the field study, 66 medicinal plant species belonging to 62 genera and 36 families used to heal different illnesses were recorded. Fabaceae has the dominant family with 8 plant species and Apocynaceae and Moraceae with 5 plant species followed by Malvaceae, Poaceae, Solanaceae, and...
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Posted by admin on Jan 31, 2020 in |
Quinolines bears a very good synthon so that a variety of novel heterocyclic with good pharmaceutical profile can be designed. There are various biological activities for quinolones such as antibacterial, antimalarial and various drugs possessing quinolone as nucleus are ciprofloxacin (Cipro), lomefloxacin (Maxaquin), norfloxacin (Noroxin), ofloxacin (Floxin), moxifloxacin (Avelox) and levofloxacin (Levaquin). So, in the present work 2-chloro quinoline 3-carbaldehyde containing quinolines were synthesized by using solvent conservation techniques like reflux technique. Various quinolines derivatives were synthesized by the condensation reaction between dimethylformamide, PoCl3, and different substituted aniline to give 2-chloro 3-carbaldehyde (1a). The reaction of 2-chloro 3- carbaldehyde with metformin gives quinolines Schiff bases as final compound (2a-2d). The obtained product was purified and structures were confirmed by TLC, MP & IR spectroscopy. All the compounds were screened for in-vitro anti-inflammatory activity using diclofenac sodium as standard by using protein denaturation method. Further, the selected compounds also studied for anti-inflammatory activity by in-vitro methods and anti-oxidant activity by hydrogen peroxide methods. Some of the compounds have shown significant...
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Posted by admin on Jan 31, 2020 in |
Objective: The aim of the present study was the evaluation of the protective role of escitalopram in streptozotocin-induced diabetic neuropathy. Materials and Methods: Diabetes was induced in Wistar rats with streptozocin 70 mg/kg and animals were divided into four groups namely normal control, diabetic vehicle control, glibenclamide control and escitalopram group. After the 4th week of diabetes induction treatment was started for further 28 days (5th to 8th week) with escitalopram 20 mg/kg. Evaluation of diabetic neuropathy was performed after 8 weeks of single injection of streptozotocin (70 mg/kg i.v.) in rats. Blood glucose level, grip strength, locomotor activity, pain sensitivity and threshold in diabetic rats were measured. Results: The results of the present study indicate that the 8 weeks treatment of escitalopram demonstrates hypoglycemic effect; it marked decreases the blood glucose level in diabetic treated animals. There was also decrease in the grip strength in diabetic rat indicates to induction of neuropathy or nerve damage. Escitalopram increases the grip strength of diabetic rats. There was also found loss of pain perception in...
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Posted by admin on Jan 31, 2020 in |
Calcium and iron are the main minerals needed to support performance and also to improve the physical components of soccer players. This study aims to analyze the effect of goat milk consumption on calcium and blood hemoglobin levels in junior soccer players. This study was an experimental study with a pretest-posttest design. Research subjects were 22 soccer players, male, aged 12-14 years. The treatment was 250 mg fresh goat milk, given 3 times a week (every Tuesdays, Thursdays, and Sundays), between 06.00 pm-06.30 pm) after playing football for 90-120 min and given for 21 days. Examination of blood calcium levels was conducted using O-cresolphthalein complexone. Examination of hemoglobin levels was performed using the method of calorimetry. Data were analyzed using homogeneity of variance (p<0.05), a test of normality (p<0.05) and paired t-test (p<0.05). The results showed that the average calcium level increased about 1.72% from 9.43 mg/dL to 9.50 mg/dL; (p=0.05) and the mean blood hemoglobin level increased about 9.2% from 14.25 g/dl to 14.55 g/dl (p=0.05) after consuming...
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