Posted by admin on Oct 31, 2019 in |
Introduction: Control of blood glucose level is a critical approach in the management of diabetes mellitus and its complications. This study investigated the α-amylase inhibition and erythrocyte membrane stabilization effect of extracts of Maesobotrya dusenii Hutch. Method: Powdered stem bark of M. dusenii (100g) was extracted with methanol. The plant material (400g) was also successively macerated with N-hexane, ethyl acetate, and methanol. Phytochemical screening was conducted on the powdered stem bark. All the extracts were evaluated for alpha-amylase inhibition at 10, 20, 30, 40 and 50 µg/mL concentrations using acarbose as standard drug and erythrocyte membrane stabilization at 20, 40, 60 and 80 µg/mL concentrations using diclofenac as standard drug. Gas Chromatography-Mass Spectroscopy (GC-MS) of the hexane extract was analyzed. Result: Phytochemical screening showed the presence of carbohydrates, saponins, and triterpenoids. All the extracts showed a dose-dependent response on alpha-amylase inhibition in which crude methanol had a significant activity of 56.7% inhibition. N-Hexane, ethyl acetate, and crude methanol extracts showed erythrocyte membrane stabilizing effect, but crude methanol showed the...
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Posted by admin on Oct 31, 2019 in |
Aim: This study was planned to keep in view on the medicinal and nutritional importance of wood apple pulp, and to utilize them by value-added product as fresh pulp incorporated spread and its dry powder incorporated cookies. Objectives of the study: To develop food products by using wood apple pulp and its dry powder and to analysis the nutritional value antioxidant content and phytochemical properties in the developed food products. Methods: By using AOAC methods for nutrient composition the wood apple fruit incorporated food products were analyzed for the nutrients, namely moisture, protein, fat and ash, minerals like sodium, potassium, calcium, and iron. The carbohydrate content of the sample was computed by a different method. Results and Discussion: Based on the sensory evaluation both the products were highly acceptable (variation 3) for palatability. All major and minor nutrients were detected in the highly accepted (variation 3) food products. Conclusion: The wood apple pulp incorporated spread and wood apple dry powder incorporated cookies are low in cost but high in...
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Posted by admin on Oct 31, 2019 in |
Stroke is a medical condition in which poor blood flow to the brain results in cell death and is the second most common cause of death after coronary artery disease. Stroke patients with added co-morbidities on an average are prescribed with 6-10 medications which increase the potential for Drug-Related Problems (DRPs) including inappropriate dose or indication for medication and Adverse Drug Events (ADEs). DRPs may be defined as “an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes.” Several studies support medication reconciliation as a mean to reduce ADEs and improve medication use safety. Medication reconciliation is the “process of comparing a patient’s medication orders to all the medications that the patient has been taking.” Hence, the aim was to assess the impact of medication reconciliation and patient counseling in stroke patients along with identification and categorization of DRPs and conducting patient counseling with the aid of PIL card. The most prominent DRP reported it was associated with treatment effectiveness. The correlation between...
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Posted by admin on Oct 31, 2019 in |
Diabetes mellitus is a major endocrine metabolic disorder of multiple etiologies characterized by chronic hyperglycemia; with disturbances of carbohydrate, protein, and fat metabolism. It is caused by the deficiency or ineffective production of insulin by pancreas, which results in increase or decrease in concentrations of glucose in the blood. There is number of chemical agents available to control and to treat diabetic patients, but total recovery from diabetes has not been reported till date. An alternative to these synthetic agents, many herbal plants with hypoglycaemic properties are known from across the world. The World Health Organization (WHO) has listed 21,000 plants, which are used for medicinal purposes around the world. The aim of the present study was to determine the anti-diabetic activity of the hydroalcoholic extracts of bark of Anacardium occidentale, whole aerial part of Achyranthes aspera and leaf of Aegle marmelos. Wistar rats were made diabetic by a single dose of alloxan monohydrate (120 mg/kg, i.p.). Hydroalcoholic extracts were screened for antidiabetic activity in alloxan-induced diabetic rats at a...
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Posted by admin on Oct 31, 2019 in |
Objective: This study was an attempt to explore the latent of colon specificity approach utilizing pH-sensitive and time-dependent characteristics of polymers for defined colonic release of 5-Fluorouracil (5-FU). Method: The pellets were prepared by extrusion-spheronization method which is an industry-accepted method due to its ease of formulation. The prepared pellets were the matrix of 5-Fluorouracil with pH-sensitive and time-dependent polymers, i.e. Eudragit FS30D and Eudragit NM30D respectively. The changing pH media used for in-vitro release study of optimization batches for both the polymer concentrations. The Optical microscopy and Scanning electron microscope (SEM) was used to evaluate texture and surface morphology. Results: The t10%, t30%, t50%, and t90% values for optimized formulation were found as 2.7 h, 6.2 h, 8.7 h and 18.2 h respectively. These values were extrapolated from in-vitro release vs. time plot which also indicated that the required lag time of 6-8 h was achieved. The in-vivo roentgenography or X-ray imaging study was used to confirm the lag time and transition path of colon targeted matrix pellets....
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