Posted by admin on Jan 31, 2020 in |
Fast disintegrating tablets have received ever-increasing demand during the last decade, particularly the fast disintegrating tablet drug delivery systems formulated with natural polymers have more demand because natural materials are easily available, easy to administer, non-toxic and non-irritant nature etc. The main aim of the present study was to formulate the fast dissolving tablet of Ofloxacin using Hibiscus leaves and Okra fruit dried mucilage. The results obtained from the natural polymer were compared with the synthetic super disintegrants sodium starch glycolate. Ofloxacin in an antibacterial drug used to treat various infections and having bitter taste. Its bitter taste is first masked by entrapping it into microspheres using Eudragit RL 100 polymer. The microspheres were evaluated for particle size, entrapment efficiency, in-vitro release and bitterness threshold. The selected microspheres were directly compressed into the tablets. The orodispersible tablets using different super disintegrants with varying concentrations were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, drug content, disintegration time and drug release. FTIR and DSC study of drug...
Read More
Posted by admin on Jan 31, 2020 in |
The validated analytical method was applied for estimation of vorapaxar in aqueous and human plasma with vorapaxar-D5 as an internal standard by using UPLC-ESI-MS/MS. The chromatographic separation was achieved with 5mM Ammonium Formate Buffer (pH: 4.0): Methanol: Acetontrile, (40:30:30, % v/v) using the Pursuit XRs-100Å, C18, 4.6 × 50 mm, 10 µm. The total analysis time was 3.5 min and flow rate was set to 0.2 ml/min. The mass transitions of vorapaxar and vorapaxar-D5 obtained were m/z 591.4®447.2 and 498.6®447.2. The standard curve shows correlation coefficient (r2) greater than 0.999 with a range of 0.01-200.0 ng/ml using the linear regression model. The developed method was applied successfully for studying the pharmacokinetics of vorapaxar in rabbits....
Read More
Posted by admin on Jan 31, 2020 in |
In the current scenario, high concentrations of acrylamide (ACR), a water-soluble vinyl monomer, which is used industrially and also found in thermally processed carbohydrate-rich foods, poses serious health risks to humans. Oxidative stress is an important mediator of central and peripheral neurotoxicity, which is one of the most recognized toxicological effects of high concentration acrylamide exposure in humans and experimental animals. The present study was designed to investigate the protective effect of Morus nigra fruit extract against acrylamide induced neurotoxicity modeled in Danio rerio (Zebrafish). Mulberry fruit is rich in mostly polyphenolic compounds such as anthocyanins and flavonoids. Forty zebrafishes were randomized into three experimental groups, (I) normal control group, (II) 0.75mM ACR treated group and (III) post ACR fruit extract-treated group. Upon completion of 72 h of ACR-exposure, a few exposed fishes were randomly selected for treatment with the fruit extract. In the ACR-treated group, a significant elevation in lipid peroxidation with concomitant depletion in the activities of catalase, glutathione reductase and acetylcholinesterase were observed in the zebrafish...
Read More
Posted by admin on Jan 31, 2020 in |
AIM: To monitor the adverse drug reactions due to various antidepressants prescribed in patients coming to psychiatry OPD with depression at a tertiary care hospital in northern India. Methods: This was a prospective observational longitudinal study conducted for a period of 12 months in a tertiary care outpatient facility. Patients who fulfilled the inclusion and exclusion criteria and those who gave informed consent were recruited. The antidepressant prescribed to the patient was noted and the patient was followed for a period of 6 months for complaints of any adverse effects. Results: A total of 96 patients were monitored for adverse drug reactions. ADRs were only recorded in the SSRIs group of patients of which only escitalopram and sertraline were prescribed to patients. 20.8% of the patients developed adverse events of which the most common were nausea, followed by a headache. Other observed adverse events that were recorded were anxiety, dry mouth, vomiting, somnolence, fatigue and sexual dysfunction. Conclusions: Prevention of adverse drug reactions occurring due to antidepressants can be...
Read More
Posted by admin on Jan 31, 2020 in |
Neuropathic pain is commonly comorbid with mood disorders, such as depression and anxiety. A state of depression may suggest biochemical imbalance that can increase the oxidative stress into the brain. The present study aimed to investigate the effect of aqueous extract of the red algae Sphaerococcus coronopifolius on depression-induced behavioral alterations and oxidative stress in female Wistar rats. Sciatic nerve injury was employed to induce depression in rats. Antidepressant-like effect of S. coronopifolius was investigated using two models: the forced swimming test (FST) and the open field test (OP). Three groups of rats were considered: The first group served as a control. The second group was subjected to sciatic nerve ligation (untreated group). The third group was subjected to sciatic nerve ligation treated daily by intraperitoneal injection of 25 mg algae extract kg−1 body weight of rat during two consecutive weeks(treated group). At the end of the experiment, rats were sacrificed and brain tissues were isolated to determine the activities of catalase (CAT) and glutathione-S-transferase (GST) as well as...
Read More
