Posted by admin on Mar 31, 2025 in |
The aim of the present work was to develop clindamycin phosphate-loaded nanosuspension lyophilized powder for axillary osmidrosis caused by bacterial activity in apocrine glands. The formulation prepared using the solvent/antisolvent method included Eudragit L100, PVP K30, and Tween 80. Optimization via central-composite design (CCD) yielded formulation with a particle size of 179 nm and viscosity of 1.35 cps. Characterization confirmed favorable sedimentation volume, drug content and zeta potential with SEM revealing a spherical and porous structure. Lyophilization improved stability and permeability, and in-vitro studies demonstrated 24-hour drug release. Antibacterial testing showed good efficacy against Staphylococcus aureus indicating potential of clindamycin nanosuspension as a promising topical delivery system with enhanced...
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Posted by admin on Mar 31, 2025 in |
Onychomycosis is a fungal infection of fingernails and toenails which accounts for majority of all nail disorders caused by Dermatophytes, Candida and Nondermatophytic Molds. Numerous Antifungal formulations are available in the market in the form of cream, ointment, lotion, powder, and solutions which require high concentration of active agents to be incorporated and have short residence time on the nail bed leading to inadequate penetration and lower efficacy. In the current study an effort is given to develop a superior alternative dosage form using essential oil as an antifungal agent. A medicated antifungal nail lacquer containing Tea Tree oil was developed using different penetration enhancers followed by evaluation of critical quality attributes. The formulation containing both Thioglycolic acid and salicylic acid at the concentration of 15% w/v exhibited favorable characteristics including non-volatile content, drug release, drug content, antimicrobial efficacy and permeability. The formulation containing both thioglycolic acid and salicylic acid exhibited prolonged release for around 12 hours with good permeability. Moreover, the nail lacquer forms a stable film immediately...
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Posted by admin on Mar 31, 2025 in |
The investigation of herbal components in topical formulations is a response to the growing desire for natural and effective remedies. The development, modification, and characterization of a topical herbal hydrogel intended for use in dermatological applications are the main objectives of this work. During the formulation procedure, plant extracts of Turmeric, Aloe vera and Marigold were chosen for well-known medicinal properties. Viscosity and spreadability of herbal hydrogel were optimized. Spreadability and viscosity were the response variables that were employed in the design of formulation. The viscosity and spreadability of the optimized formulation were 176000 m Pa. S and 8.25 g.cm/sec respectively. Phytochemical screening confirmed that the active phytoconstituents present in the herbal hydrogel. According to the antioxidant study, the herbal formulation exhibited good radical scavenging activity, reaching up to 78.02%. Attenuated total reflectance infrared (ATR-IR) spectroscopy revealed that there were no major interactions between the excipients and the herbal drugs. The microstructure of formulated herbal hydrogel was observed using field emission scanning electron microscopy (FE-SEM) imaging, which also showed...
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Posted by admin on Mar 31, 2025 in |
Background: Medicinal plants are gaining popularity due to their reputation for being safe and effectively addressing fundamental health care demands. Standardizing medicinal products is the most recommended option because herbal therapy is becoming more and more popular worldwide. Objective: The present study examines various pharmacognostic characteristics that ensure the safety, efficacy, and purity of P. plebeium. Materials and Methods: The present work aimed to investigate the pharmacognostical and phytochemical screening of P. plebeium aerial parts by using energy dispersive spectroscopy (EDX), field emission scanning electron microscopy (FE-SEM), fluorescence, and Fourier transform infrared (FTIR) spectroscopy techniques. Results: The scanning electron microscope (SEM) analysis detected the presence of xylem parenchyma, phloem parenchyma, and calcium oxalate crystals. The physicochemical characteristics of P. plebeium indicate that the sulphated ash value (7.6%) is greater than the values of total ash, acid-insoluble ash, and water soluble ash. The fluorescence study of raw powdered drugs revealed a variety of colours substance present in it. The preliminary phytochemical profile identified secondary phytocostituents such as alkaloids, carbohydrates, flavonoids, proteins,...
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Posted by admin on Mar 31, 2025 in |
The utility of herbal medicines incresed for curative purposes in the past few years. They serve as a curative alternative for a significant section of the worldwide community. Nonetheless, assessing the reliability of such facilities continues to be challenging in guaranteeing their safe use. Acute and subacute toxicity studies were conducted in a rat model. The cytotoxicity assay and AO/PI staining of HALEPR was carried out in an endometrial cell. Acute toxicity was evaluated in female Charles Foster rats over 14 days, revealing no mortality or severe adverse effects, suggesting a Lethal Dose 50 (LD50) above 2000 mg/kg. Subacute toxicity was assessed over 28 days with no significant changes (P < 0.05) in body weight, feed consumption, water intake, or biochemical parameters. Histological examination of organ tissues indicated no notable differences between treated and control groups. The antiproliferative activity of HALEPR was investigated using primary endometrial cell cultures. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay demonstrated a significant apoptotic effect with an IC50 of 41.46 µg/mL. This result was further confirmed...
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