Posted by admin on Sep 30, 2019 in |
Metabolic syndrome is a group of several clinical conditions which is related to the prevalence of another disease such as cardiovascular disease, diabetes mellitus (DM) or increased fasting blood glucose level, visceral obesity, hypertension, etc. The major factor that affects the metabolic syndrome occurrence is diet composition.This research aimed to determine the influence of diet composition on metabolic syndrome prevalence. This study was performed using in-vivo method. The animal was divided into three groups, each administered a different composition of diet, which was high carbohydrate, high lipid, and high protein diet for 42 days. The parameters were body weight, HDL and triglyceride level, blood glucose level, and blood pressure. The results showed that each diet composition affected the glucose, HDL, triglyceride, and blood pressure level differently. The high-fat diet gave the most significant effect in HDL reducing and blood pressure elevation, while the high carbohydrate diet gave the most significant effect in blood glucose and triglyceride level elevation. It could be concluded that the lowest affecting food to metabolic...
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Posted by admin on Sep 30, 2019 in |
Cyclic imides such as succinimides, maleimides, phthalimide and their derivatives contain an imide ring and a general structure –CO-N(R)-CO- that confers hydrophobicity and neutral nature. Succinimide (pyrolidine 2,5-dione) is a synthetically versatile substrate used for the synthesis of heterocyclic compounds and as a raw material for drug synthesis. Derivatives of succinimide are of important biological and pharmaceutical uses such as antibacterial, antifungal, anticonvulsant, antitumor and antinociceptive. In spite of these activities, much of their action mechanisms at molecular and cellular levels remain to be elucidated. A new series of nickel(II) and copper(II) complexes of a new mannichbase1-((2,5-dioxopyrrolidin-1-yl)(4-methoxyphenyl) methyl) thiourea (LIGAND) have been synthesized. The structures of newly synthesized compounds have been explicated on the basis of elemental analysis, molar conductance, IR, UV-Visible, NMR, Mass, and Magnetic measurements. The binding of the copper sulfate complex of the ligand with calf thymus DNA has been investigated using absorption spectroscopy, fluorescence spectroscopy, and viscosity...
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Posted by admin on Sep 30, 2019 in |
Aim of the present study was to evaluate the antianxiety and antidepressant activity of Valeriana pyrolaefolia, a member of family Valerianaceae. The antianxiety and antidepressant activities of dichloromethane extract were evaluated using the elevated plus-maze model and porsolt’s despair swim test. The studies were conducted on lacca mice, and the test materials were administered per oral route. The dichloromethane extract of V. pyrolaefolia roots exhibited significant dose-dependent antianxiety activity at 400 mg/kg. The results were comparable to the standard diazepam (2 mg/kg). The extract also exhibited significant antidepressant activity at 400 mg/kg dose. The results were comparable to the standard imipramine (10 mg/kg). The TLC fingerprint profile of the bioactive extract was developed using precoated TLC plates of 0.2 mm thickness. Valtrate was used as a bioactive marker for developing TLC fingerprint profile. The solvent system comprising dichloromethane: ethyl methyl ketone (8: 2) was used for developing the TLC profile. The TL chromatogram showed valtrate as a major component of the...
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Posted by admin on Sep 30, 2019 in |
Metallic toxicity associated with Ayurvedic formulations like herbomineral preparation (Bhasma), especially because of heavy metals such as lead, has always been a matter of debate in the scientific community. Instead of that, ancient Ayurvedic literature reveals that sodhana process used for the preparation of such formulations, either decreases or eliminate the toxic effect of such heavy metals up to a negligible extent. But, the method for their standardization should be well defined. In present work, marketed lead preparation (Bhasma), In-house prepared lead preparation, and their corresponding micro/nano-particle have been evaluated for their physiochemical properties and toxicological impact. For the toxicity studies, instead of animals, two different methods like enzymatic inhibition and change in the growth pattern of yeast cells were explored to find out and establish the toxicity of such preparations. The results of the study reveal that sodhana process significantly effects to the physicochemical character of the metallic preparation and presence of heavy metals like lead effects to the activity of enzymes and growth pattern of the yeast...
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Posted by admin on Sep 30, 2019 in |
The objective of this study was to evaluate the toxicity of a saponin isolated from the fruits of the Momordica dioica as per OECD guidelines. Saponin was isolated from the methanolic extract of the fruits of M. dioica, and acute, sub-acute, sub-chronic and chronic toxicity was evaluated. The study of the acute toxicity of saponin M. dioica (SMD) at a single dose of 5000 mg/kg/b.w. by oral route in, recorded no mortality, and showed no change in the general behavior of the treated rats for 14 days. Administration at the doses; 1000, 500, and 250 mg/kg/b.w. by oral route in rats for 28 days and an animal showed doses of 500 and 250 mg/kg/b.w. of SMD was safe, no mortality for sub-acute but in a repeated dose of 1000 mg/kg/b.w. group produced treatment-related signs of toxicity. The study of Sub-chronic toxicity at the doses; 500, 250 and 100 mg/kg/b.w. of SMD in rats for 90 days and animals showed normal; hematological and biochemical parameters and gross findings compared to...
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