Posted by admin on Aug 31, 2019 in |
Chromolaena and Lantana plants were analyzed to evaluate the existence of allelopathic effect using fully viable seeds of mung bean as the bioassay material. The study shows that pretreatment of mung bean seeds with various concentrations [1:1 and 1:2 (w/v)] of Chromolaena and Lantana leaf leachate for 24 h interval reduced the percentage germination. DNA and RNA contents were significantly reduced with a remarkable increase of amylase activity in seed samples pretreated with leaf leachate of Chromolaena and Lantana. The seedling performance was found to be much poor when the seedlings were raised from seeds which underwent pretreatment with the plant leachates. Evidenced from the lower levels of chlorophyll, DNA and RNA as well as a higher level of amylase activity in leaves of seedlings. Leaf leachate causes the reduction of germinability and influenced activity of amylase enzyme being the important allelopathic indices; it can be concluded that Chromolaena and Lantana can potentially render allelopathic action on mung bean. It further reemphasizes the fact that fast-growing exotic invasive weeds...
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Posted by admin on Aug 31, 2019 in |
The present investigation aims to evaluate the effect of methanol extract of Spatoglossum asperum for its anti-hyperglycemic activity against diabetics induced by alloxan in Wistar albino rats. Artificially diabetes was induced in albino rats by the administration through injection of a single dose of alloxan monohydrate (10 mg/kg, I.P). The 10 mg/kg methanol residue of S. asperum was administered as a single oral dose per day to diabetes-induced rats for 28 days. The outcome of algae residue feeding was estimated by various biochemical and hematological parameters such as RBC, WBC, Hb, and platelets and lipid profile. After feeding of algal methanol extract of S. asperum in diabetic rats for 28 days, the blood glucose had significantly decreased, whereas the liver glycogen level had increased. Histopathological examination of the pancreas was done. The methanol residues of the Spatoglossum asperum possess very effective anti-hyperglycemic activity on the diabetic rats as compared to...
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Posted by admin on Aug 31, 2019 in |
Planterosomal gel exhibit better pharmacokinetic and pharmacodynamic profile than the conventional herbal extracts. The objective of the present research work was to develop, characterize and evaluate the in-vitro antifungal activity of planterosomal gel in comparison to pure plant extract. Planterosomal gel of Ganoderma lucidum was prepared by incorporating gelling agent in planterosomal suspension. Planterosomal gel of G. lucidum was subjected to different evaluation parameters like pH, spreadability, in-vitro release study, ex-vivo permeation study, and in-vitro antifungal activity. Results of in-vitro release studies and ex-vivo skin permeation studies showed that the planterosomal gel releases the active ingredients in a controlled manner and showed higher skin permeability in comparison to G. lucidum gel. The optimized planterosomal gel showed moderate antifungal activity when compared with a standard antifungal agent. So, it was concluded that the planterosomal gel is an advanced form of herbal formulation which enhances the retention time and skin permeability when applied...
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Posted by admin on Aug 31, 2019 in |
Sumatriptan succinate is the 5H1 receptor agonist and used in the treatment of migraine, cluster headache. The main objective is to develop ideal anti-migraine nasal mucoadhesive microparticles as local and systemic drug delivery system. An attempt was made to formulate the nasal mucoadhesive microparticle of Sumatriptan succinate with excipients like mucoadhesive polymers i.e., HPMC, ethyl cellulose, etc., by using modified solvent evaporation method. And evaluated them for production yield, drug loading efficiency, surface morphology by SEM, drug content, particle size, in-vitro drug release studies. The release rates were studied using GraphPad Prism software. The prepared micro-particles of Sumatriptan succinate formulations were found to be satisfactory particle size i.e., in the range of 33.3 to 59.94 µm, mucoadhesion time of F5 found to be 321 min drug content was found to be 81.79 % to 89.16%, and drug release of the drug follows zero order kinetic model. Optimized formulation F5 shows that the developed formulations have shown improved dissolution profile in comparison to other formulation. The developed nasal mucoadhesive microparticles...
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Posted by admin on Aug 31, 2019 in |
Most of the simulation methods for soft tissue modeling involve tetrahedral meshes which is quite complex and takes much computation time. Instead, this work attempts to make use of delaunay triangulated mesh that consists of unique mathematical properties suited for simulating soft tissues. Although, triangulated mesh is not so complex yet effective in producing elements of good quality. It even reduces computation time compared to the tetrahedral mesh by providing more geometric flexibility. In virtual surgery, it is essential to model the layers of soft tissues of human skin to perform a simulation of deformation and removal of cells. Based on this the multilayered model of skin prototype is developed in a pre-process and used for interactive modeling. This work presents a simple method for performing real-time collision detection in a virtual surgery environment. Also shows the efficient computation of collisions between the scalpel and delaunay triangulated mesh using a local collision detection function. The framework incorporates qualitative results obtained towards the simulation of surgical deformation and removal of...
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