Posted by admin on Sep 30, 2019 in |
Objective: The purpose of the present study to develop gastro-retentive drug delivery formulation for enhancing GRT, including the physiological and formulation variables affecting gastric retention. It is a widely employed approach to retain the dosage form in the stomach for an extended period and release the drug slowly that can address many challenges like poor bioavailability. Methods: Floating microspheres were prepared by solvent evaporation (oil-in-water emulsion) technique. In this 225 mg poly(methyl methacrylate) (PMMA) were dissolved in a mixture of dimethylformamide and dichloromethane (1:1) at room temperature. And 75 mg nizatidine hydrochloride was added in the above mixture. This was poured into 250 ml water containing 0.02% tween 80, maintained at a temperature 30 – 40 ºC and subsequent stirred at ranging agitation speed for 20 min to allow the volatile solvent to evaporate. The microspheres formed were filtered, washed with water and dried in vacuum. Results: The prepared floating microspheres were characterized in a different way like size distribution 131.4 ± 1.6 µm and 89.5 ± 1.4% entrapment...
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Posted by admin on Sep 30, 2019 in |
Background: Chloramphenicol capsules are found in several brands with different prices in the market. This study aimed to obtain in-vitro biopharmaceutics quality data from the generic and branded name products. Methods: Ten products were selected, consisted of 3 generics (A, B and C) and 7 branded names (D, E, F, G, H, I and J); F was chosen as an innovator. The dissolution test was performed by using the basket method in medium 0.01 N HCl pH 1.28 ± 0.05; the analysis was done using spectrophotometer UV-Visible at 277.6 nm. The dissolution profiles were analyzed using a kinetic equation and similarity factor. AnX-ray diffraction analysis was done to confirm the results. Results: There were no significant differences in the amount dissolves in 20 minutes between the innovator and other products (p>0.05). Products A, C, H, I and J were similar with the innovator; the f2 values were 54.82; 50.74; 66.16; 91.34 and 51.35% respectively. Other products (B, D, E, and G) were not similar. The diffractogram showed similar pattern...
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Posted by admin on Sep 30, 2019 in |
The microbial pigments have more applications than synthetic pigments and are easily biodegradable and safe to use. Among all bacteria, the anoxygenic phototrophic purple non-sulfur bacteria have more applications and can synthesize different pigments. In this present study, bacterial carotenoids were isolated from the two novel strains of Rhodopseudomonas palustris and evaluated its applications. The antibacterial activity was studied by zone inhibition method. The pigment A1 and A2 showed more antibacterial activity against gram-negative and gram-positive bacteria. In-vitro antioxidant activity of bacterial pigments and bacterial extracts were evaluated by DPPH assay. The pigment A2 and Rp. KRPR02 showed more radical scavenging activity. The percentage inhibition of DPPH radical for pigment A2 (82.74 ± 4.49) and bacterial extract of Rp. KRPR02 bacteria (83.33 ± 5.46) is almost nearer to the percentage inhibition of DPPH radical for standard (ascorbic acid) which is 96.41 ± 1.81. In-vitro cytotoxic activity was studied by MTT assay and found that the pigments showed cytotoxic activity against the HeLa cell line, DU145 cell line, MCF7 cell...
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Posted by admin on Sep 30, 2019 in |
In the present study, the pharmaceutical and therapeutic dimensions of Shankha Bhasma (Classical Ayurvedic marine medicine) is explored as a substitute for calcium supplements available in the market. Shankha Bhasma was prepared & standardized by Ayurvedic pharmaceutical procedure accordingly in Rasa Tarangini (a classical 20th-century book on Ayurvedic pharmaceutical medicine). Conch shell (Shankha) was subjected to bio-fomentation (Swedana) in a precise heating container (Dolayantra) containing lemon juice for 12 h. Further, triturated with Aloe vera juice (Kumari Swarasa) for bio-impregnation (Bhavana) and subjected to the controlled quantum of heat (Marana) in the sealed earthen saucer at 700 °C for 2 h, till all the classical and contemporary quality parameters about bio-metallic medicinal powder (Bhasma) was assured. On completion, average weight loss was 17-21%. The final product obtained was calcite form of CaCO3 and calcium oxide hydrate (CaO.H2O). This paper explores scientific evidence of ancient Ayurvedic pharmaceutical procedures in terms of bio-fomentation, bio-impregnation, transfer mechanism of quantum of heat along with the principles of fluid mechanics &...
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Posted by admin on Sep 30, 2019 in |
The objective of the present study was to formulate and evaluate a gastro-retentive stomach specific novel floating in-situ gelling system of curcumin for potentially treating gastric ulcer, associated with Helicobacter pylori. The in-situ gel of curcumin was prepared by dissolving different concentrations of gelling polymer like sodium alginate in distilled water at 60 ºC. After cooling to 40 ºC, required quantities of sodium citrate and calcium carbonate were dispersed in it with continuous stirring followed by the addition of curcumin and sorbitol. Identification of drug was confirmed by DSC (melting point study), FTIR (functional groups study), and UV spectrophotometric analysis. Compatibility between drug and polymer were confirmed by DSC and FTIR studies. The micromeritic properties of curcumin were done, and all formulations showed pH in the range of 6.6 to 7.4, floating lag time was less than 1 min, duration of floating was more than 24 h for all the prepared formulations. Gelling capacity, gel strength, viscosity, and water uptake by the gel increased with the increase in sodium...
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