Posted by admin on Oct 31, 2019 in |
Melastoma malabathricum is a medicinal plant found throughout Southeast Asian countries. Traditionally M. malabathricum was used for treating diseases such as hemorrhoids, cuts and wounds, toothache, and stomachache. Scientific findings also revealed the wide pharmacological actions of various parts of M. malabathricum such as anti-nociceptive, anti-inflammatory, wound healing, anti-diarrheal, cytotoxic, and antioxidant activities. The present study evaluated the mechanism of action of the anti-inflammatory activity of M. malabathricum. Initially different solvent extracts of M. malabathricum were evaluated for total phenolics, total flavonoids, anti-oxidant activity, anti-inflammatory activity (protein denaturation), anti-cancer activity (prostate cancer cell line), and for sPLA2 inhibition. Results showed that ethanolic extract of Melastoma. malabathricum leaves showed higher phenolic and flavonoid concentrations, i.e. 36.77mg GAE/g dry wt. and 245.5 mg QE/gm of dry weight, respectively. Ethanol extract also exhibited the highest free radical scavenging activity in the DPPH method and phosphomolybdenum assay of which the IC50 values were 77.424 µg/ml and 95.159 µg/ml respectively. The anti-inflammatory assay (protein denaturation assay) of leaf extract showed the IC50 value of 45.518 µg/ml. Further, the extract exhibited...
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Posted by admin on Oct 31, 2019 in |
Pharmacists play a vital role in providing counseling to the hypertensive patients to understand disease, risk factors, medications, and non-pharmacological measures required in controlling Blood Pressure (BP). This study aims to evaluate the impact of pharmacist delivered counseling services on KAP levels and control of BP in hypertensive patients. A prospective, open-labeled, randomized control trial was conducted among hypertensive patients attending medical outpatient department of Non-governmental Organization (NGO) Hospital located in rural settings in Anantapur district, Andhra Pradesh, India. The study was performed after getting ethical clearance from the Institutional Review Board with a registration number of RIPER/IRB/2018/038 and in accordance with ICH-GCP and CONSORT guidelines. The study was carried out for a period of one year from February 2018 to January 2019. The findings of the study reveal that there was a significant difference in the mean systolic and diastolic BP levels in intervention (138 ± 10.5, 82.3 ± 7.2) and control group (146.0 ± 8.2, 87.2 ± 5.4) at final follow-up visits. The mean percentage of knowledge,...
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Posted by admin on Oct 31, 2019 in |
A novel starch was isolated from weed rice crop and its starch properties were compared with rice starch. The starch properties studied were physicochemical, pasting, thermal and X-ray diffraction. The amylose content and swelling power (g/g) of weed rice starch was 13.7% and 19.8 g/g, respectively. Light transmittance (%) of starch paste from weed rice was observed higher as compared to rice starches. Pasting properties (PV, TV, SB, and FV) of weed rice starch was within the range of those earlier reported for rice starches. The transition temperatures (To, Tp and Tc) and enthalpy of gelatinization (ΔHgel) were evaluated by using differential scanning calorimetry (DSC). The values of To, Tp and Tc were 68.86, 77.45 and 82.05 °C, respectively, for weed rice. ΔHgel value for weed rice starch was 3.80J/g which was significantly lower than that of rice starches (8.09-13.81J/g). X-ray diffractions behavior for both weed and conventional rice starches exhibited a typical A-type pattern which is normally reported for cereal starches. Weed rice starch was also studied for...
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Posted by admin on Oct 31, 2019 in |
Objective: The objective of the study was to evaluate the in-vivo anticancer and antioxidant activity of methanolic extract of leaves of Annona reticulata Linn. on EAC induced solid tumor. Methodology: Tumor cells (1 × 106 cells/mice/I.M.) were injected into the hind limb for solid tumor formation, and the treatment started from day 1 for 14 days. Group 1 served as a Normal control, Group 2 served as EAC control, whereas Group 3 served as a standard group (5-FU, 20 mg/kg/ip), & Group 4 & Group 5 served as test drug 100 & 200 mg/kg/po respectively. During the treatment, the different groups are checked with the parameters like Mean survival time, % increase in life span, Average body weight, Tumours size, on 15th day the blood was withdrawn for hematological parameters, SGOT, SGPT, ALP, and liver & tumor was isolated for histopathology studies, simultaneously antioxidant was carried out. Results and Conclusion: A significant increase in the life span and a decrease solid tumor volume were noted in the tumor-induced mice...
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Posted by admin on Oct 31, 2019 in |
Objective: To assess the reproductive toxicity of concoction of Andrographis paniculata in male Wistar albino rats. Methods: 18 male Wistar albino rats were divided into 3 groups with 6 animals in each group. Group 1 served as control and received distilled water. Group 2 and 3 received 0.5 ml of a concoction of Andrographis paniculata and Nilavembu kudineer (a concoction of 9 herbs) respectively for 30 days. Serum testosterone levels were measured at the baseline and at the end of the study. Animals were sacrificed at the end of the study, and histopathological examination of testes and sperm analysis were carried out. Results: There were no significant changes in the body weight and general behavior of the animals within the groups and between the groups. The differences noted in mean sperm count, as well as the qualitative characteristics such as progressive & non-progressive sperms and percentage of immotile sperms among the 3 groups, were not significant. Histopathology of testes did not show any difference between the control and treated...
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