Posted by admin on Jul 31, 2019 in |
The objective of this study was to formulate luteolin with radioisotope Technetium-99m (99mTc) to be 99mTc-Luteolin as an antioxidant compound. After optimization, this radiopharmaceutical preparation should be examined for its physicochemical characteristics, such as radiochemical purity, stability, lipophilicity, protein plasma binding, electronic charge, and stability test. The formulation was done by mixing the luteolin compound with radioisotope 99mTc by using SnCl2 as a reducing agent. Radiopharmaceutical compound 99mTc-Luteolin was formed, then tested for physicochemical characteristics. The result of radiochemical purity was 98.19% ± 1.30%, Log P 0.95 ± 0.07, protein plasma binding 38.01% ± 4.28%, and had neutral charges, test stability at room temperature showed that the radiopharmaceutical purity value was better than in plasma. The results obtained in this research work indicated 99mTc-Luteolin radiopharmaceutical compounds had good physico-chemical properties and were relatively stable in room temperature than in blood plasma. This optimization condition has the potential to be developed into a radiopharmaceutical...
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Posted by admin on Jul 31, 2019 in |
The purpose of this study is to formulation and evaluation of floating and mucoadhesion microspheres of etodolac using ionic gelation method. The floating and mucoadhesion microspheres were studied for micromeritic properties were found to be within limits. The percentage yield of floating microsphere formulation F1 to F6 and mucoadhesive microspheres M1 to M3 were in the range of 77.14 ± 0.64 to 92.74 ± 0.74%. The in-vitro buoyancy of formulation F1 to F6, it was range from 71.96 ± 1.04 to 82.96 ± 1.07. Among all formulation, F6 was found to be highest in-vitro buoyancy 82.96 ± 1.07. The results also showed that the larger the particle size, the longer the floating time. The entrapment efficiency of floating microspheres F1 to F6 and mucoadhesive microspheres were in the range of 77.43 ± 2.72 to 98.11 ± 2.59. Formulations prepared with sodium alginate alone have shown maximum drug release at 12 h in the ratio of 1:3. Formulations prepared with sodium alginate along with HPMC K 4M retard the drug...
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Posted by admin on Jul 31, 2019 in |
Periodontal disease is one of the most prevalent oral diseases is caused by the gram-negative bacterial infection of periodontal pocket identified by inflammation of subgingival plaque and degeneration of alveolar bones, teeth, dental cementum, and periodontal ligaments. 80% of American adult and more than 50% of the Indian community suffers from this chronic inflammatory infection depicting the severity of the Periodontitis disease. The available therapies are to minimize the bacterial infection and to regenerate the damage done by infection and inflammation. The therapies involve systemic therapy, conventional therapy, as well as local therapy. The localized drug delivery system using anti-bacterial drug Moxifloxacin is a fourth generation fluoroquinolone antibiotic drug used in periodontal infections. The present study aimed at designing and evaluating Eudragit-coated pectin microspheres for localized controlled release of drug to achieve a minimum inhibitory concentration in the periodontal pocket. The microspheres were prepared by emulsion dehydration technique using pectin as a polymer coated with Eudragit RS100. The formulation B2 were characterized by particle size, Scanning electron microscopy (SEM),...
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Posted by admin on Jul 31, 2019 in |
The genus, Rubus is considered as highly potent plant crop and possesses economical, medicinal and ecological importance. Rubus plant species have been utilized inbreeding programme and has identified various pharmaceutical compounds. However, the taxonomy of the genus Rubus has been in a state of flux, because of the absence of comprehensive work and associated taxonomic disputes. Among the genus, most of them are referred to as ‘unresolved name” in the scientific database. The present study discussed the microscopic characterization of one unresolved species, ‘Rubus indicus’ and the examination were carried out by using their vegetative parts (root, stem and leaf). The systematic study of this high potent wild crop (R. indicus) has not been reported so far; hence, the resolved characters may be useful for proper species identification and for meaningful...
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Posted by admin on Jul 31, 2019 in |
The most striking feature of natural products in connection to their long-lasting importance in drug discovery is their structural diversity that is still largely untapped. Most natural products are not only sterically more complex than synthetic compounds but also differ in regards to the statistical distribution of functionalities. The chemical diversity and unique biological activities of a wide variety of natural products have propelled many discoveries in chemical and biological sciences and provided therapeutic agents to treat various diseases as well as offered leads for the development of valuable medicines. The present study has been designed to screen the phytochemicals and to evaluate the antibacterial potential of Nigella sativa L. seeds against ESBL positive Escherichia coli isolates. The crude extracts of Nigella sativa L. seeds were prepared by utilizing two methods namely Soxhlet extraction and Supercritical Fluid Carbon dioxide (SCFE-CO2) extraction. Preliminary phytochemical analysis revealed the presence of alkaloids, flavonoids, phenols, tannins, saponins, and terpenoids which are known to exhibit medicinal as well as physiological activities. The Supercritical Fluid...
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