Posted by admin on Sep 30, 2019 in |
Rapid precorneal elimination of the drug in conventional ophthalmic solution leads to poor bioavailability and less therapeutic response, which can be overcome by the use of in-situ gel forming system that is instilled into the eye and undergoes a sol-gel transition in the cul-de-sac. The aim of the present study was to formulate and evaluate pH-triggered in-situ gels for ophthalmic delivery of ofloxacin. Ofloxacin ophthalmic solution is commonly used in the treatment of bacterial eye infection. The in-situ gelling systems were prepared by using different concentrations of carbopol 934 as a gelling agent in combination with hydroxypropyl methylcellulose (HPMC) E15LV as a viscosity enhancing agent. The prepared formulations were then evaluated for visual appearance, clarity, pH measurement, gelling capacity, rheological studies, and drug content. The developed formulation was therapeutically efficacious and stable. Thus the developed system can be used as a viable alternative to conventional eye...
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Posted by admin on Sep 30, 2019 in |
Ichnocarpus frutescens (Apocynaceae) generally renowned as Kali Sariva in Sanskrit, Krishna Sariva in Hindi which is a large, evergreen, red woody climber, native to India, Java, China, Southeast Asia, Ceylon, Northern Australia and found ascending to an altitude of 4,000 ft. Different tribes of India are used this plant as a substitute of Indian Sarsaparilla (Hemidesmus indicus). It has been used conventionally in various diseases and disorders of human being that is a headache, wound, fever, tongue ulcers, cramps, night blindness, stomach pain, bone fracture, skin infection, diabetes, liver disorders, as alterative, tonic, diuretic and diaphoretic. Pharmacologically plant shows different activities include anti-diabetic, anticarcinoma, antiurolithiatic, antiobesity, analgesic, antipyretic, anti-inflammatory, skeletal muscle relaxant, antitumor, hepatoprotective. The present study was aimed to identify the phytocomponents present in I. frutescens using GC-MS analysis. The aerial plant part was extracted successively by solvents according to their increasing order of polarity using Soxhlet apparatus. The phytocomponents of ethanolic extract was identified by GC-MS investigation and found 19 number of phytocomponents. The major constituents of...
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Posted by admin on Sep 30, 2019 in |
Background: The irrational uses of antibiotics play a crucial role in emerging of antimicrobial resistance. So regular review of the prescribing patterns represents an effective monitoring study that enhances rational prescription of antibiotics. This study evaluated the prescribing pattern of antibiotics at Al-Rass hospital in Qassim region. Methodology: A retrospective cross-sectional study was approved by the Regional Research Ethics Committee and conducted at Al-Rass hospital. A total of 3595 emergency prescriptions and 1203 from in-patient were evaluated, and only 177 antibiotics prescriptions were included in the study. Descriptive statistics were used in the analysis of data. Results: Among 240 antibiotics prescribed in 177 prescriptions, 58.7% were for female. Antibiotics were commonly prescribed for upper respiratory tract infections (URTI) in 26.6% and lower respiratory tract infections (LRTI) in 16.4%. The most commonly prescribed antibiotic was amoxicillin/clavulanate (26.9%), and it was mostly prescribed for URTI. The second antibiotic was ceftriaxone (25.2%) with high prescription in obstetrics and LRTI. For surgical prophylaxis metronidazole was mostly prescribed (5.5%), followed by ceftriaxone (4.3%). Paracetamol...
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Posted by admin on Sep 30, 2019 in |
Calcium oxide nanoparticles (CaO NPs) gain great value in the areas of energy storage and drug delivery systems. Due to good porosity, it finds its part in storage systems and its biocompatibility earns it a good value in drug delivery and gene transfection. Synthesis of nanoparticles by waste materials and plants of metal oxide is gaining considerable interest due to environmentally friendly reactants and room temperature synthesis. This is most using method of preparation of nanoparticles as it makes use of pollution-free chemicals and encourages the use of non-toxic solvents such as water and plant extracts. In this present study, the calcium oxide nanoparticles synthesized by the eco-friendly green synthesis using environmentally begin waste chicken egg shells. CaO nanoparticles show better antibacterial activity. CaO was bio modified by Cissus quadrangularis, Acalypha indica, Solanum nigrum, Phyllanthus niruri to enhance the antibacterial activity, then the antibacterial activity of pure CaO and bio modified CaO was investigated against B. substilis, S. aureus and E. coli species. The synthesized nanoparticles have been characterized...
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Posted by admin on Sep 30, 2019 in |
Background: Oleogel is a thermo-reversible, viscoelastic, semi-solid self-assembled preparation in which an apolar phase gets immobilized within a 3-D networked structure formed via physical or chemical interaction with different organogelators. Objective: The objective of the present investigation was to develop drug-loaded (paracetamol) Span 40 / Tween 80-based soybean oleogels for topical application and to establish a relationship between viscosity, flexibility, thermal stability and drug release of the oleogels by modeling of gelation and release kinetics. Method: Span 40(gelator)/Tween 80(surfactant)-based soybean oleogel formulations were prepared and subjected to organoleptic evaluation, FTIR spectroscopy, thermal analysis, viscosity study, kinetic modeling of gelation and drug release. Results: Tween 80 reduced critical gelator concentration (CGC) of Span 40-based oleogels and also enhanced their thermal stability and viscosity. Gelation time was lowered with the increase in concentration of span, but surfactant addition increased the gelation time. Gompertz model was employed on gelation kinetics data for determination of oil parameter (α) and organogelator parameter (β) which were found to be linked to gel flexibility and thermal...
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