Posted by admin on Sep 30, 2019 in |
Background: Garlic has been used in world culinary art as well as in herbal medicine since long back. Allicin, an active moiety in garlic, is truly recognized as heart of garlic. But allicin is highly unstable and undergoes formation of numbers of sulfur-containing compounds with reduced allicin content. The major problem associated with dosage form development is instability of allicin. Objective: The aim of the present research work was to obtain a stable garlic powder from the garlic bulbs with maximum allicin content with prolonged physical and chemical stability of the garlic powder. The target was to improve household storage for culinary purpose as well increased active drug content proclaimed for long term utilization in dosage form design. Methodology: The principles of microwave drying technology and the flower drying technology along with some modifications have been successfully utilized for preparing, processing and preserving garlic powder to improve its medicinal and culinary acceptance. Results: The allicin content was found to be increased (2533.7 µg/gm) as compared aqueous garlic extract and...
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Posted by admin on Sep 30, 2019 in |
The present research work was carried out to Formulate and evaluation of bilayer tablet dosage form for the treatment of Hypertension. The objective of this study to compare the specific characteristics of Olmesartan Midoxomil [Angiotensin II receptor antagonist] and Hydrochlorothiazide [Thiazide Diuretics] in order to design stable formulation. It can be concluded that Olmesartan Midoxomil [Angiotensin II receptor antagonist] and Hydrochlorothiazide [Thiazide Diuretics] were successfully formulated in combination as a Bilayer tablet form with Croscarmellose sodium, Lactose monohydrate and microcrystalline cellulose PH101 for immediate release of both drugs. Both drugs were found to be stable in Bilayer tablet formulation and were found to be stable up to 6 months. This bilayer tablet dosage form increases the stability which may reduce loss and cost of formulation. It improves the benefits of producer, retailer, and patients. Recently, greater attention has been focused on development of bilayer tablet formulations. Over the past 30 years, the expenses and complications involved in marketing new drug entities have increased with concomitant recognition of therapeutic advantages...
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Posted by admin on Sep 30, 2019 in |
Background: Type 2 diabetes is a major lifestyle disease often seen with comorbidities or complications. This study is conducted to find out the gender-wise prevalence of comorbidities and medication adherence among the diabetics in Malappuram. Methods: A cross-sectional study was conducted among the 179 diabetics selected for the study. A pre-tested interview schedule was used to collect information about their socio-demographic details, clinical characteristics, co-morbidities and awareness on complications. Anthropometric measurements and blood pressure of each patient were recorded. Body Mass Index, Waist Hip Ratio and Household Dietary Diversity Score were calculated. The results were analyzed statistically. Results: The selected diabetics comprised of 46.4% males and 53.6% females. Around 91% of them were sedentary workers. Early-onset of diabetes at the age of 35-45 years was reported among males (p<0.05). Blood sugar monitoring, insulin usage, and exercise were higher among males while the medication regularity was higher among females. Higher prevalence of obesity (62.5%), hypertension (53.1%) and hypercholesterolemia (59.5%) were observed among the female diabetics. The prevalence of retinopathy (15.7%)...
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Posted by admin on Sep 30, 2019 in |
Objective: The purpose of the present study to develop gastro-retentive drug delivery formulation for enhancing GRT, including the physiological and formulation variables affecting gastric retention. It is a widely employed approach to retain the dosage form in the stomach for an extended period and release the drug slowly that can address many challenges like poor bioavailability. Methods: Floating microspheres were prepared by solvent evaporation (oil-in-water emulsion) technique. In this 225 mg poly(methyl methacrylate) (PMMA) were dissolved in a mixture of dimethylformamide and dichloromethane (1:1) at room temperature. And 75 mg nizatidine hydrochloride was added in the above mixture. This was poured into 250 ml water containing 0.02% tween 80, maintained at a temperature 30 – 40 ºC and subsequent stirred at ranging agitation speed for 20 min to allow the volatile solvent to evaporate. The microspheres formed were filtered, washed with water and dried in vacuum. Results: The prepared floating microspheres were characterized in a different way like size distribution 131.4 ± 1.6 µm and 89.5 ± 1.4% entrapment...
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Posted by admin on Sep 30, 2019 in |
Background: Chloramphenicol capsules are found in several brands with different prices in the market. This study aimed to obtain in-vitro biopharmaceutics quality data from the generic and branded name products. Methods: Ten products were selected, consisted of 3 generics (A, B and C) and 7 branded names (D, E, F, G, H, I and J); F was chosen as an innovator. The dissolution test was performed by using the basket method in medium 0.01 N HCl pH 1.28 ± 0.05; the analysis was done using spectrophotometer UV-Visible at 277.6 nm. The dissolution profiles were analyzed using a kinetic equation and similarity factor. AnX-ray diffraction analysis was done to confirm the results. Results: There were no significant differences in the amount dissolves in 20 minutes between the innovator and other products (p>0.05). Products A, C, H, I and J were similar with the innovator; the f2 values were 54.82; 50.74; 66.16; 91.34 and 51.35% respectively. Other products (B, D, E, and G) were not similar. The diffractogram showed similar pattern...
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