Posted by admin on Sep 30, 2019 in |
This study was aimed to investigate the effects of different levels of dietary chromium picolinate (CrPic) on performance, some blood biochemical and intestinal morphology and microflora in Ross 308 broiler chicks. A total of 240 broiler chickens Ross 308 strain, from 21 to 42 days old were used in a completely randomized design. All chickens consumed a diet based on the corn-soybean meal, and the treatments were control- (thermo-neutral) and control + (heat stress) with no add-on and the others with CrPic supplementation at levels 500, 1000 and 1500 ppb respectively. The blood serum samples were subjected to biochemical analysis for blood parameters. The histomorphometric examination was performed by light microscopy. The result showed that all the growth and feed intake and feed conversion ratio parameters were declined when the broilers fed the CrPic supplementation (P≤0.05). The serum glucose concentration decreased CrPic supplemented groups. As a result, revealed that the villus height and crypt depth in the ileum and jejunum. Ileal villus height of birds on CrPic groups was...
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Posted by admin on Sep 30, 2019 in |
Modified Benzoxazocine moiety of Nefopam with N-Protected-ethanolamine, fluorobenzene benzylbromide, 2,3-dimethyl-benzene, naphthalene, fluro-naphthalene. In these modification Friedel Craft alkylation plays vital role with using grignard reagent and aluminum chloride with the starting phthalic anhydride to form acid compound and was converted to amide compound with using of thionyl chloride, N-Protected ethanol amino and further converted to benzhydrol follows two synthetic routes, one routes is amide is converted to choro intermediate with thionyl chloride and then converted to benzhydrol, and another route is amide compound is directly converted into benzhydrol. Benzhydrol is the key intermediate for the preparation of all Nefopam analogs. These benzhydrol is undergone cyclization with p-Toluene sulfonic acid to forms benzoxazocine moiety of Nefopam analogs, by these ways disclosed nefopam analogs containing Benzoxazocine moiety as a novel analgesic therapeutic compounds, and these compounds were characterized by IR, 1H NMR Mass...
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Posted by admin on Sep 30, 2019 in |
Pugai (fumigation) is one among the external medicines in treating a variety of diseases with the fumes of herbs or aromatic substance. Peenisa pugai is an external therapeutic measure that has been indicated in Siddha literature for the effective management of Peenisam that can be symptomatically correlated with that of Sinusitis. The aim of the present Pilot study was to compare the efficacy of internal therapy alone (Gowrisinthamani chendooram and Thirikaduku chooranam) with that of internal therapy in combination with Peenisa pugai. The clinical study was conducted at Ayothidoss Pandithar hospital, National Institute of Siddha, Chennai- 47. In this study, 60 patients with sinusitis were divided into two groups Group A and Group B. Group A (30 Patients) were administered with internal medicine alone (NIS OPD Medicine) & Group B included 30 patients with internal medicines along with Peenisa pugai. Pugai was externally administered for 10 min with the time interval of 5 days up to 5 sittings. The Prognosis of each patient was assessed by Friedman and katsantonis...
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Posted by admin on Sep 30, 2019 in |
Rapid precorneal elimination of the drug in conventional ophthalmic solution leads to poor bioavailability and less therapeutic response, which can be overcome by the use of in-situ gel forming system that is instilled into the eye and undergoes a sol-gel transition in the cul-de-sac. The aim of the present study was to formulate and evaluate pH-triggered in-situ gels for ophthalmic delivery of ofloxacin. Ofloxacin ophthalmic solution is commonly used in the treatment of bacterial eye infection. The in-situ gelling systems were prepared by using different concentrations of carbopol 934 as a gelling agent in combination with hydroxypropyl methylcellulose (HPMC) E15LV as a viscosity enhancing agent. The prepared formulations were then evaluated for visual appearance, clarity, pH measurement, gelling capacity, rheological studies, and drug content. The developed formulation was therapeutically efficacious and stable. Thus the developed system can be used as a viable alternative to conventional eye...
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Posted by admin on Sep 30, 2019 in |
Ichnocarpus frutescens (Apocynaceae) generally renowned as Kali Sariva in Sanskrit, Krishna Sariva in Hindi which is a large, evergreen, red woody climber, native to India, Java, China, Southeast Asia, Ceylon, Northern Australia and found ascending to an altitude of 4,000 ft. Different tribes of India are used this plant as a substitute of Indian Sarsaparilla (Hemidesmus indicus). It has been used conventionally in various diseases and disorders of human being that is a headache, wound, fever, tongue ulcers, cramps, night blindness, stomach pain, bone fracture, skin infection, diabetes, liver disorders, as alterative, tonic, diuretic and diaphoretic. Pharmacologically plant shows different activities include anti-diabetic, anticarcinoma, antiurolithiatic, antiobesity, analgesic, antipyretic, anti-inflammatory, skeletal muscle relaxant, antitumor, hepatoprotective. The present study was aimed to identify the phytocomponents present in I. frutescens using GC-MS analysis. The aerial plant part was extracted successively by solvents according to their increasing order of polarity using Soxhlet apparatus. The phytocomponents of ethanolic extract was identified by GC-MS investigation and found 19 number of phytocomponents. The major constituents of...
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