Posted by admin on Sep 30, 2019 in |
Background: The irrational uses of antibiotics play a crucial role in emerging of antimicrobial resistance. So regular review of the prescribing patterns represents an effective monitoring study that enhances rational prescription of antibiotics. This study evaluated the prescribing pattern of antibiotics at Al-Rass hospital in Qassim region. Methodology: A retrospective cross-sectional study was approved by the Regional Research Ethics Committee and conducted at Al-Rass hospital. A total of 3595 emergency prescriptions and 1203 from in-patient were evaluated, and only 177 antibiotics prescriptions were included in the study. Descriptive statistics were used in the analysis of data. Results: Among 240 antibiotics prescribed in 177 prescriptions, 58.7% were for female. Antibiotics were commonly prescribed for upper respiratory tract infections (URTI) in 26.6% and lower respiratory tract infections (LRTI) in 16.4%. The most commonly prescribed antibiotic was amoxicillin/clavulanate (26.9%), and it was mostly prescribed for URTI. The second antibiotic was ceftriaxone (25.2%) with high prescription in obstetrics and LRTI. For surgical prophylaxis metronidazole was mostly prescribed (5.5%), followed by ceftriaxone (4.3%). Paracetamol...
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Posted by admin on Sep 30, 2019 in |
Calcium oxide nanoparticles (CaO NPs) gain great value in the areas of energy storage and drug delivery systems. Due to good porosity, it finds its part in storage systems and its biocompatibility earns it a good value in drug delivery and gene transfection. Synthesis of nanoparticles by waste materials and plants of metal oxide is gaining considerable interest due to environmentally friendly reactants and room temperature synthesis. This is most using method of preparation of nanoparticles as it makes use of pollution-free chemicals and encourages the use of non-toxic solvents such as water and plant extracts. In this present study, the calcium oxide nanoparticles synthesized by the eco-friendly green synthesis using environmentally begin waste chicken egg shells. CaO nanoparticles show better antibacterial activity. CaO was bio modified by Cissus quadrangularis, Acalypha indica, Solanum nigrum, Phyllanthus niruri to enhance the antibacterial activity, then the antibacterial activity of pure CaO and bio modified CaO was investigated against B. substilis, S. aureus and E. coli species. The synthesized nanoparticles have been characterized...
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Posted by admin on Sep 30, 2019 in |
Background: Oleogel is a thermo-reversible, viscoelastic, semi-solid self-assembled preparation in which an apolar phase gets immobilized within a 3-D networked structure formed via physical or chemical interaction with different organogelators. Objective: The objective of the present investigation was to develop drug-loaded (paracetamol) Span 40 / Tween 80-based soybean oleogels for topical application and to establish a relationship between viscosity, flexibility, thermal stability and drug release of the oleogels by modeling of gelation and release kinetics. Method: Span 40(gelator)/Tween 80(surfactant)-based soybean oleogel formulations were prepared and subjected to organoleptic evaluation, FTIR spectroscopy, thermal analysis, viscosity study, kinetic modeling of gelation and drug release. Results: Tween 80 reduced critical gelator concentration (CGC) of Span 40-based oleogels and also enhanced their thermal stability and viscosity. Gelation time was lowered with the increase in concentration of span, but surfactant addition increased the gelation time. Gompertz model was employed on gelation kinetics data for determination of oil parameter (α) and organogelator parameter (β) which were found to be linked to gel flexibility and thermal...
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Posted by admin on Sep 30, 2019 in |
In-silico computational approaches help in ascertaining drug targets via bioinformatics tools. HER2 is the most valuable therapeutic target for breast cancer therapy. The overexpression of HER2 protein plays a very critical role in the progression of breast cancer. Plant-derived natural products have received increasing attention over the past 20-30 years for their potential as novel therapeutic agents. In the future, plant products may offer more effective medicines than synthetic drugs. The main aim of the current study helps to develop new anti-cancer drug candidates from natural and dietary compounds with the help of computational approaches. In this context, the plant-derived compounds resveratrol and its related analogs were taken and docked onto the protein active site (PDB ID:1M14) via structure-based virtual screening for the prediction of novel potential inhibitors, which may be used as anticancer drugs against breast cancer. Furthermore, Molinspiration server and Data warrior software tools were used to evaluate the ADMET profiling and physicochemical parameters of the screened compounds. The best compound was identified, showing good binding affinity...
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Posted by admin on Sep 30, 2019 in |
The present paper portrays a simple, rapid, nonextractive spectrophotometric method for the estimation of an anticholinergic drug, Ipratropium Bromide. The method is based on the formation of an instantaneous stable yellow colored ion pair complex of drug with a chloroformic solution of reagent Bromophenol Blue (BPB) which shows absorption maxima at 416 nm. Job’s plot of continuous variation affirmed the development of 1:1 complex between drug and reagent. The optical parameters were optimized, and the calibration curve was found to be linear in the range of 10 µgmL-1 to 80 µgmL-1. The detection limit was found to be 2.75 μg mL-1 with Sandell’s sensitivity 0.083 μgcm-2. Stability constant (log Kf) was calculated as 6.6. Molar absorptivity was found to be 4.29 × 103 L mol-1 cm-1 with Gibb’s free energy change of – 3.1 × 104 kJ mol-1. The method was validated as per ICH guidelines and had many advantages like low detection limits, high sensitivity and not requiring adjustment of critical conditions, thus paving the way for the...
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