Posted by admin on Sep 30, 2019 in |
Rhus pentaphylla (Jacq.) Desf. (Searsia pentaphylla (Jacq.) FA. Barkley) is used for its colorant and tanning properties by the local population. The bark, leaves, roots, and fruits are employed in Moroccan traditional medicine to treat gastrointestinal disorders and diarrhea. Nevertheless, the pharmacological properties of R. pentaphylla on cardiovascular diseases have not yet been presented. This study was carried out to explore the vasorelaxant effect of the aqueous extract (decoction) from the leaves of R. pentaphylla (RpAE), its mechanism of action, and its antihypertensive effect. The results of this study demonstrate that RpAE induces a dose-dependent effect on isolated rat aorta. The vasorelaxation is endothelium-dependent via the muscarinic receptor, Calmodulin/eNOS/sGC/cGMP/PKG signaling pathway through the activation of SERCA pump, the inhibition of VOCC, and opening of KCa2+ channels. In-vivo, RpAE induces antihypertensive effect, ameliorates diuresis, and vascular reactivity on L-NAME induced hypertensive rats. The oral administration of RpAE reveals no mortality or toxicity. This is the first study in Morocco showing vasorelaxant and antihypertensive effects of species belonging to genus...
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Posted by admin on Sep 30, 2019 in |
Natural Herbal components like seeds mucilages, exudates, gums, polysaccharides, celluloses, hemicelluloses, starch, etc. are now a day’s exploited as excipients. Literature reveals medicinal, nutraceutical and pharmaceutical uses of fenugreek seed hemicelluloses in dosage form design. Hemicelluloses like galactomannans are water-soluble polysaccharides highly susceptible to hydrolysis either by acidic conditions or by uncontrolled hydrothermal processes. Chances of breakdown of intact polymeric polysaccharides chains into oligosaccharides, disaccharides, monosaccharide, etc. increases. Conversion into basic sugar units may also take place leading to changes in the polymeric behavior of the intact structures. So, in the present research percentage hemicellulose recovery is determined by invasive, indirect method in terms of basic glucose units. FTIR-SEM-DSC analysis was found to be useful characterization tools to interpret and support the recovery details of the hemicellulose isolates. Finally, it is concluded that the method of isolation of any natural component either hemicellulose, cellulose, etc. targeted to be utilized as excipient entity in dosage form design should be strictly optimized because there are numerous factors in processing which may...
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Posted by admin on Sep 30, 2019 in |
Chemical, physical, and biological methods have been developed to synthesis nanoparticles but chemical and physical methods are involved in the production of toxic by-products which are hazardous moreover the methods are very expensive. To synthesis stable metal nanoparticles with controlled size and shape, there have been searched for inexpensive, safe, and reliable and “green” approach. The present study reports an environmentally friendly, low cost, novel and rapid method for synthesis of silver nanoparticles. We have developed a green synthetic method for silver nanoparticles using Cassia tora leaf extract which acts as a reducing & capping agent. It was observed that use of Cassia tora leaf extract makes rapid and convenient method for synthesis of silver nanoparticles and can reduce silver ions into silver nanoparticles within few seconds of reaction time. UV-Vis spectrometer uses to monitor the reduction of Ag ions and formation of AgNPs in medium. The morphological studies of the biosynthesized nanoparticles are done using UV-Vis, HRTEM & FESEM techniques FTIR was performed to identify the functional groups...
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Posted by admin on Aug 31, 2019 in |
Stevioside glycosides (SGs) are a class of diterpene glycosides being produced by leaves of Stevia rebaudiana. Stevia is getting agricultural importance due to the production of natural sweetener steviol glycosides, also called as zero-calorie sweeteners. Earlier it was thought that steviol was synthesized from Kaurene via MVA pathway but later on it was concluded that precursors of steviol are actually synthesized via the plastid localized methylerythritol 4-phosphate (MEP) pathway. In total, seventeen enzymes are used in this biosynthetic pathway. Each enzyme plays a significant role in the subsequent production of rebaudioside A and other SGs. In order to understand those enzymes functionally, understanding of those genes evolution basically in the Asteraceae family is highly warranted. In this study, the National Center for Biotechnology Information (NCBI) was searched to retrieve amino acid sequences that encode MEP pathway enzymes homologs. A number of MEP pathway enzymes’ amino acid sequences from the Asteraceae family were phyleticaly analyzed to light the way for the evolution characteristics of sweetener-producing plants homologs. The study is...
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Posted by admin on Aug 31, 2019 in |
The present study deals with the identification of the phytochemical compounds in ethanol, acetone and benzene extracts from polyherbal formulation composed of the bark of Ficus religiosa, the root of Smilax chinensis, seeds of Nigella sativa, the fruit of Emblica officinalis, Terminalia chebula and Terminalia bellerica which is used to treat psoriasis. The bioactive components of different extracts of the polyherbal formulation were determined by liquid chromatography coupled with mass spectroscopy (LC-MS) analysis. LC-MS analysis of the ethanol extract of the polyherbal formulation revealed the presence of the 9 bioactive chemical constituents, 5 phytochemicals in the acetone extract of polyherbal formulation and the benzene extract consist of 4 bioactive compounds. The results of this present study provide scientific support to medicinal uses of the polyherbal formulation. These compounds may exhibit an antipsoriatic activity which can be done in further...
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