Posted by admin on Aug 31, 2019 in |
Alcohol use disorders (AUDs) recognized as substantial public health problem. It is grown-up many risk factors influence on alcoholism including social, behavior, an environment, and heredity conditions on the global. Alcuremon preparation was based on medicinal herbs and used for the treatment of alcohol-related disease and alcoholic liver disease in traditional Mongolian medicine. Male Wistar rats were used to induce alcoholic liver disease and chronic ethanol (EtOH) intoxication with neurotransmitter imbalance by oral administration of ethanol (subchronic 30% EtOH 10 ml/kg/day for 14 days and chronic 40% EtOH 7 ml/kg/day for 60 days). Alcuremon 50, 100 and 150 mg/kg were given orally for the same day as ethanol administration days. Some biochemical parameters and liver HE stains were examined in subchronic intoxication with alcoholic liver disease. Chronic ethanol-induced neurotransmitters changes were measured by enzyme-linked immunosorbent assay (ELISA) in brain homogenate of nucleus accumbens (NAc) and ventral tegmental area (VTA). Hippocampus was stained with cresyl violet. Data were expressed as mean ± SD. The difference between the groups was compared...
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Posted by admin on Aug 31, 2019 in |
Background: The association between metabolic syndrome and cognitive impairment is not well established. The aim of the present study was to estimate the prevalence of cognitive impairment in adults with metabolic syndrome (MetS). Methods: Cross-sectional observational study conducted in patients with metabolic syndrome (n=185). All patients were subjected to written informed consent, anthropometric measurements, neuropsychological assessments using Mini-Mental State Examination (MMSE). MetS was diagnosed using the definition by the National Cholesterol Education Program- Third Adult Treatment Plan. The main outcome measure was cognitive impairment (<24 on the MMSE scale). Mean, standard deviation and students t-test were used to carry out the analyses. Results: The prevalence of cognitive impairment in MetS patients was 24%. Patients age ranged between 20-75 years and 45% (n= 83) of them were female. MMSE scores were lower in female patients compared to male, however, the difference was not significant (p=0.06). College graduates had significantly higher MMSE scores than patients with just a high school education (p<0.05). Patients with high levels of triglycerides had significantly lower...
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Posted by admin on Aug 31, 2019 in |
The aim of the present work was to develop and evaluate the potential of nanostructured lipid carriers (NLCs) loaded with Clobetasol-17-propionate (CP) as a new approach for the topical treatment of psoriasis. CP-loaded NLCs were prepared by melt emulsification and ultra-sonication method and optimized using 33 full factorial designs (Design-Expert software 11.0), by using solid lipid (compritol ATO 888) and liquid lipid (oleic acid) and Tween 80 as a surfactant. Drug loaded NLCs were evaluated for various parameters like particle size, surface charge, polydispersity index, entrapment efficiency, surface morphology, thermal analysis, in-vitro drug release through the skin (Franz diffusion cell), drug deposition study and stability. The optimized formulation has a particle size of 91.2 ± 2.37 nm, the zeta potential of -34.7 ± 1.49 mV, polydispersity index of 0.173 ± 0.035 and entrapment efficiency of 85.4 ± 2.89%. Release study demonstrated prolonged CP release from NLCs following Higuchi release kinetics with r2 = 0.9838, while pure CP suspension showed quicker drug release obeying zero-order kinetics with r2 value of...
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Posted by admin on Aug 31, 2019 in |
Simple, sensitive, cost-effective and selective methods are designed and developed for the oxidative indirect spectrophotometric determination of drugs and pharmaceuticals, viz., Argatrobane Monohydrate (ARG), Bortezomib (BOR), Chloroquine Phospate (CHP), Granisetron HCl (GRA), Ibandronate Sodium (IBA) based on their reactivity towards n-bromo succinamide (NBS in excess). The method is based on the oxidation of drugs by n-bromo succinamide (excess) and estimating the amount of un-reacted NBS by Methyl Orange dye at λmax 508 nm. The calibration curves obeyed Beer’s law over the concentration range of 10-70 µg mL-1 (ARG), 8-56 µg mL-1 (BOR), 6-42 µg mL-1 (CHP), 4-28 µg mL-1 (GRA) & 5-35 µg mL-1 (IBA). This method has been applied for the determination of drugs in their pure form as well as in tablet formulations. Statistical analysis of the results using Student’s t-test for accuracy and F-test for precision revealed no significant difference between the proposed methods and the literature method at the 95% confidence level with respect to accuracy and precision. The method has been validated in terms...
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Posted by admin on Aug 31, 2019 in |
Benzofuranone is a bicyclic ring where a benzene ring fused with a furanone. Synthetic chemistry plays a major in developing a series of potent anti-cancer agents. Bromophenyl acetonitrile was prepared from phenyl acetonitrile by bromination at an alpha position which yielded bromophenyl acetonitrile which was a lachrymator compound. Benzofuranone was synthesized by reacting benzene diols and triols with bromo phenyl acetonitrile yielded an imine derivative are converted to a ketone with treatment with hydrochloric acid then cyclized with sodium acetate. The compounds identity and purity are confirmed by spectral and analytical methods. Benzofuranone derivatives are screened anti-neoplastic activity was performed against human skin cancer cell line G361 at micro molecular concentrations. The compounds IA, IB, ID, IE, IF, IIB, IIC, IIIA, IVB, IVF, VA, VC, VD, VE was found to be with potent activity. These compounds exhibited an excellent activity while compared to reference standard doxorubicin at different micromolar concentrations as such of the synthesized...
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