Posted by admin on May 31, 2019 in |
Quality of life is an essential measure that proves the effectiveness of health care, health level, and well-being. Kidney diseases are one of the major health problems that affect Quality of life. This study aimed to assess the quality of life in dialysis (CRF-D) and non-dialysis (CRF-ND) chronic renal failure (CRF) patients using Kidney Disease Quality of Life-short form (KDQOL-SFTM) and identify the differences in disease symptoms between these two groups. 200 CRF patients were included in the study. Our findings showed that some symptom burden was higher in the non-dialysis group compared to the dialysis group, but most of the symptoms did not reach statistical significance. Similarly, our results indicate no differences in quality of life and symptoms between CRF patients with dialysis and without...
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Posted by admin on May 31, 2019 in |
Adenocalymma alliaceum is an important medicinal plant belongs to the family Bignoniaceae. The antibacterial and phytochemical studies on the leaves of this plant were carried out by using the disc diffusion method and Thin Layer Chromatography. The methanolic leaf extract showed a brown colored band on TLC plate with an Rf value 0.25 represents the presence of sulfide compound. The extract was tested against four bacterial strains, namely Enterobacter aerogenes, Salmonella enterica, Vibrio cholerae (gram positive) and Streptococcus haemolyticus (gram negative). The activity was determined by measuring the diameter of zone of inhibition in mm. The result obtained from the present study indicates that the methanolic leaf extract was active only against gram-positive bacteria. The maximum zone of inhibition was recorded in Salmonella enterica (12...
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Posted by admin on May 31, 2019 in |
Schizophrenia is a chronic and complex mental disorder characterized by hallucinations and delusions that significantly affect emotions, behavior, and mental processes. Currently used antipsychotics are characterized by the multireceptor mode of action (antagonism of dopamine D2 and serotonin receptors), there is no consensus regarding an “ideal” target engagement. Moreover, they are associated with adverse effects. Presently the focus is on the search for safe and efficacious drugs from the traditional system of medicine. In the present study, an attempt has been made to evaluate the multitarget antipsychotic activity of Unmadgajakesari – A herbomineral formulation in animal models. Unmadgajakesari (UGK) was evaluated for its effect on dopaminergic, serotonergic and NMDA activity in the following animal models: Inhibition of apomorphine-induced climbing in mice (dopamine), Inhibition of 5-HTP induced head twitches in mice (serotonin), Antagonism of MK-801induced hyperlocomotion (NMDA) in mice. For studying each neurotransmitter, animals were divided into 6 groups, each group comprising of 6 animals. Group I – Normal control, Group II – Vehicle control (ghrita), Group III – Drug...
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Posted by admin on May 31, 2019 in |
Euphorbia resinifera Berg. (ER) an endemic Moroccan plant has been used to treat different diseases. In spite of its toxicological potential, no scientific report until now was made to evaluate in-vivo neither the toxic effect nor its immunomodulatory activity. The objective was to evaluate the safety of an aqueous extract (AE) of ER in-vivo and its effect on the biochemical, immunological and histopathological parameters. The AE was administrated in single oral dose (5g/kgbw) for the acute toxicity tests given daily by gavages at 0.1, 0.5, 1, 2.5, or 5 g/kg for 28 consecutive days. Serum was analyzed for creatinine, urea, alanine aminotransferase, and aspartate aminotransferase. Histopathological examination of liver, kidneys, and spleen was done at the end of the study. The immunological effect was tested by the evaluation of antibodies production and the level of the delayed type hypersensitivity reaction. No signs of toxicity or deaths were observed in mice treated by a single dose. In the sub-acute toxicity tests, no visible toxic effects were observed at 0.1-1 g/kg...
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Posted by admin on May 31, 2019 in |
Datura stramonium (L.), a multipurpose plant of Himalayan regions which possess antiseptic, sedative, antidiarrhoeal properties used for treating various diseases which include treatment of ulcer, skin disorder, jaundice, fever, heart diseases, etc. To evaluate the temperature stress-mediated morphological, physiochemical, and antioxidative defense in Datura stramonium, plants were subjected to different temperature conditions (High temperature and Low temperature). The seedlings were exposed to five temperature conditions (50 °C, 40 °C, 30 °C, 20 °C, and 10°C). Seedlings grown at 25 °C were treated as control. Temperature treatment significantly decreased stem length, root length, fresh weight, dry weight, and leaf area both in high temperature as well as low-temperature stress. Phytochemicals as carbohydrate, protein, alkaloids, flavonoids, ascorbic acid, tocopherol and enzymatic antioxidants, i.e. superoxide dismutase, catalase, peroxidase, glutathione reductase, glutathione-s-transferase, and DPPH increased tremendously with both temperature stresses in comparison to the control. Carotenoids and chlorophyll found increased in low temperature whereas decreased in high temperature stressed plants. HPLC analysis of secondary metabolites revealed higher alkaloids (Atropine, Scopolamine) content in high...
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