Posted by admin on Jul 31, 2019 in |
Objectives: The objective of this research was dose reduction and toxicity reduction. Dose reduction: various anti-cancer drugs are very costly, and their high dose increases cost. If bioavailability is enhanced, the dose shall be reduced thereby; the cost will also decrease. Dose reduction will also reduce toxicity, and the preparation will become more tolerable. Method: In this study, the nanoparticles were developed by using a modified method with the drug cisplatin, which was later evaluated for stability, toxicity, and therapeutic efficacy using various in-vitro and in-vivo techniques like SRB assay. Results: The resulting dosage form found to be more affected and less toxic than the marketed preparation of drug cisplatin, which is i.v. injection. As cisplatin is a platinum compound and has the biggest drawback of the toxic side effects, which is making the chemotherapy less acceptable but with the preparation of nanoparticles side effects were minimized without harming the therapeutic efficacy. Anti-cancer agents have several adverse side effects and high levels of toxicity, e.g., Hair loss due to...
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Posted by admin on Jul 31, 2019 in |
Boerhavia diffusa is a species of flowering plant in the four o’clock family, Boerhavia belongs to family Nyctaginaceae the plant holds the tremendous potential of medicinal value and has been traditionally used in various ailments like syphilis, leukoderma, blood disorders to name a few. The present study focuses on the GC-MS analysis of extracts of all the plant parts of B. diffusa which revealed the presence of certain bioactive compounds like kaempferol, luteolin, quercetin and so forth. A total of about 20 bioactive compounds were identified. In Boerhavia diffusa in all plant parts roots, stems and leaves kaempferol is observed maximum. Total amount of flavonoids was maximum in leaves and minimum in stem. Antimicrobial activity of the extracts was assayed against pathogenic bacteria and fungi. In B. diffusa, flavonoids extracted from leaf were highly active against F. oxysporium, against bacterial strains flavonoids from leaves were highly active and showed maximum activity against E. coli. The study thus infers that the presence of bioactive components may be the principle behind the...
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Posted by admin on Jul 31, 2019 in |
The genus Euphorbia has about 2000 members making it one of the largest ones among the flowering plants. Euphorbia helioscopia L. As the chemical composition of the essential oil from Euphorbia helioscopia developed in Egypt has not yet been explored, along these lines the present to extricate the essential oil and investigate the oil chemical composition and antimicrobial activity. Essential oil from the whole inflorescence of the flowering plant, Euphorbia helioscopia Linn. was extracted by hydrodistillation method. The chemical composition of the obtained volatile oil was investigated by GC-MS. The major components include thymol (48.36%), Caryophyllene (23.57%), carvacrol (6.70%), caffeic acid (6.48%) and caryophyllene oxide (5.58). Minor components as translongipinocarveol (2.77%) and DL-malic acid (1.9%). Screening antimicrobial activity of the isolated volatile oil against four bacteria showed that it was active only against Bacillus subtilis with an inhibition zone of 11 mm ± 0.25 and MIC value 17 mg /ml. Gentamycin was utilized as a positive antibacterial control. The data of this study might be considered as the first...
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Posted by admin on Jul 31, 2019 in |
One of the proposed groupings of the fluoroquinolones describes the excellent broad-spectrum activity forms an invaluable part of the present anti-infective armory of the clinicians. The fluoroquinolones are most significant weapons can be credited for saving more human lives than any other area of medicinal therapy. In this current research segment, the novel C-3 substituted fluoroquinolone scaffolds were designed, synthesized and elucidated by IR, H1NMR, and MS spectral data. The clinically banned drug gatifloxacin is acting as starting material used to obtain targeted compounds. The proposed scheme comprised of main cyclization by using phosphorous oxychloride, thiosemicarbazide, gatifloxacin. The former compounds were undergoing diazotization reaction followed by a coupling reaction with various tertiary amines. Further, all seven 3- substituted gatifloxacin derivatives (PGI-PGVII) were screened for antimicrobial and hypoglycemic activity. In the novel series of compounds PG III, PG IV, PG V exhibited good antimicrobial activity by inhibition of DNA gyrase enzyme whereas PG I, PG III, PG VI, PG VII were found to be the most active compounds with hypoglycemic...
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Posted by admin on Jul 31, 2019 in |
Bacterial resistance and oxidative stress are an important etiology of chronic diseases. This is the reason why new alternatives were established to overcome the incidence of some pathologies. Thus, the present study was aimed to evaluate the antibacterial activity of the extracted oil against bacteria that causes nosocomial infections in neonatal intensive care by using disc diffusion method. The antioxidant activity was evaluated using various methods (1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, reducing power assay, total antioxidant activity) and the content of total phenolic and flavonoids were determined. In the essential oil, the twenty-eight compound was identified by GC/MS analysis. The major components were: 1,8-cineol (26.76%), 1-α-pinene (8.63%), linalool (7.78%). The oil strongly reduced the DPPH radical (IC50 = 4. 4 µg/ml) and reducing of molybdate (0.53 ± 0.0027 mg Eq ascorbic acid/µg EO. The oil showed strong antibacterial activity against nosocomial bacteria tested. This study confirms the essential oil of laurus nobilis. L processes antibacterial and antioxidant properties...
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