Posted by admin on Jul 31, 2019 in |
The genus, Rubus is considered as highly potent plant crop and possesses economical, medicinal and ecological importance. Rubus plant species have been utilized inbreeding programme and has identified various pharmaceutical compounds. However, the taxonomy of the genus Rubus has been in a state of flux, because of the absence of comprehensive work and associated taxonomic disputes. Among the genus, most of them are referred to as ‘unresolved name” in the scientific database. The present study discussed the microscopic characterization of one unresolved species, ‘Rubus indicus’ and the examination were carried out by using their vegetative parts (root, stem and leaf). The systematic study of this high potent wild crop (R. indicus) has not been reported so far; hence, the resolved characters may be useful for proper species identification and for meaningful...
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Posted by admin on Jul 31, 2019 in |
The most striking feature of natural products in connection to their long-lasting importance in drug discovery is their structural diversity that is still largely untapped. Most natural products are not only sterically more complex than synthetic compounds but also differ in regards to the statistical distribution of functionalities. The chemical diversity and unique biological activities of a wide variety of natural products have propelled many discoveries in chemical and biological sciences and provided therapeutic agents to treat various diseases as well as offered leads for the development of valuable medicines. The present study has been designed to screen the phytochemicals and to evaluate the antibacterial potential of Nigella sativa L. seeds against ESBL positive Escherichia coli isolates. The crude extracts of Nigella sativa L. seeds were prepared by utilizing two methods namely Soxhlet extraction and Supercritical Fluid Carbon dioxide (SCFE-CO2) extraction. Preliminary phytochemical analysis revealed the presence of alkaloids, flavonoids, phenols, tannins, saponins, and terpenoids which are known to exhibit medicinal as well as physiological activities. The Supercritical Fluid...
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Posted by admin on Jul 31, 2019 in |
Ethanol extracts of rambutan leaves have been investigated for their anti-diabetes properties using the glucose tolerance method as well as insulin deficiency through alloxan induction. This study aimed to further evaluate these properties in obese and insulin resistant animals. The rat models were feeding with foods high in carbohydrates, fats, and propylthiouracil. The animal models were divided into seven groups: normal group, the positive control group, rambutan leaf extract at doses of 17.5, 35, and 70 mg/kg b.w., and the orlistat and metformin groups. The parameters evaluated during therapy were body weight, food index, feces index, and blood glucose levels. The rambutan leaf ethanol extract at a dose of 17.5 mg/kg b.w. resulted in a decrease in body weight by 2.44% compared to the initial body weight and could also decrease appetite with the amount of food intake equal to 10.71 g compared with the positive test group at 12.49 g. The rats administered 35 mg/kg b.w. rambutan leaf ethanol extract excreted 6.29g of feces and exhibited a decreased...
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Posted by admin on Jul 31, 2019 in |
The objective of the study was to determine the phytochemicals present in the leaf extracts of Diospyros blancoi A. DC and to evaluate its antioxidant and antidiabetic activities. Qualitative phytochemical tests were used to detect the presence of bioactive compounds present in leaf extracts of D. blancoi. Antioxidant activity was measured through diphenyl-1-picrylhydrazyl assay, and antidiabetic potential was done using alloxan induced white mice. Based on the results, the following bioactive constituents are present in the leaves: alkaloids, flavonoids, tannins, terpenoids, saponins, anthraquinones, steroids, and glycosides in both ethanol and water extracts of D. blancoi. Moreover, results showed that the ethanolic extract had better antioxidant activity compared to water extract. Furthermore, results also showed that both ethanolic and waterleaf extracts had significant antidiabetic effects to alloxan-induced diabetic white mice as shown in their ability to reduce blood glucose level. Results indicate that extracts of D. blancoi leaves are potential sources of natural antioxidant and antidiabetic compounds and could have potential use in the management of...
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Posted by admin on Jul 31, 2019 in |
Clopidogrel bisulphate (CB) is the rate of dissolution often controls a sparingly soluble orally administered drug and the rate of absorption. Reports suggest that the drug has poor water solubility which may be challenging for developing liquid dosage forms of Clopidogrel bisulphate. Hence in the present study, we sought to develop orodispersible nanoparticles to enhance the solubility by an anti-solvent evaporation technique using stabilizers as PVPK-30, Poloxamer-188, PVA, L-arginine and tween-80. We found that the particle size was ranging between 154.7 nm to 844.2 nm and % Drug entrapment efficiency was 42.4% to 97.1% respectively. Among all the formulations, F3 stabilized with L-arginine and PVA has been found to show 92.62 ± 0.81% drug release at the end of 10 min in both 0.1N HCl and phosphate buffer (pH6.8). Through SEM studies we found that the particles were small with no aggregation. Further, the particles (F3) were compressed into tablets F3(c) through direct compression method and characterized based on some selected parameters in comparison with the marketed tablet. We...
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