Posted by admin on Oct 31, 2024 in |
Introduction: Triphala Churna a polyherbal Ayurvedic formulation – with significant therapeutic potential is used to treat a variety of oral ailments. To ensure product’s quality and effectiveness, it is essential to evaluate its microbiological stability. Materials and Methods: Triphala Churna was prepared using standard procedures and stored in various containers for ten months under different real-world storage conditions, without specific control over temperature or humidity. Microbial contamination was assessed periodically through Gram staining for bacteria, wet mount preparation for fungal visualization, and culture methods for isolating and identifying potential microbes. Discussion: No bacterial or fungal growth was observed in any of the samples throughout the ten-month study period, even under conditions that could potentially support microbial growth. The preparation, storage, and inherent qualities of the individual ingredients in the formulation may have contributed to the observed findings. Conclusion: This preliminary study indicates good microbial stability of Triphala Churna under real-world storage conditions. However, further research using a wider range of microbial detection methods is needed for a more comprehensive...
Read More
Posted by admin on Oct 31, 2024 in |
Background: Understanding the dynamic profiling of emergency department (ED) visits, particularly among pediatric patients, is crucial for implementing targeted interventions to enhance outcomes and optimize triage systems for this vulnerable population. Aim and Objective: This study aimed to profile the demographics, clinical presentations, and treatments of pediatric patients admitted to the ED. Materials and Methods: Conducted as a prospective observational study over six months in South India, this research included 110 participants. Sociodemographic and clinical data were collected and analyzed using IBM SPSS software version 29.0. Results: The male-to-female ratio among participants was 1.2:1, with children aged 1 to 10 constituting 48.1% of the cohort. Febrile seizures emerged as the most common diagnosis, accounting for 17.3% of cases. Acetaminophen was the most frequently prescribed medication, used by 30.0% on admission and 12.7% upon discharge. Drug-drug interactions (DDI) were significant, with 92.7% classified as moderate and 7.3% as severe. The mean length of hospital stay was approximately four days, and polypharmacy was noted in 52.8% of patients. Conclusion: The predominance...
Read More
Posted by admin on Oct 31, 2024 in |
Objectives: The Indian government has revised the National List of Essential Medicines (NLEM) of India after seven long years in 2022. The objective of this study was to compare and analyse changes in the essential medicines listed in 2015 and 2022. We have also compared the listing of antibiotics in NLEM 2022 to those in the 23rd World Health Organization (WHO) Model list 2023. Materials and Methods: NLEM of 2015 and 2022 were accessed from the official website of Central Drugs Standard Control Organization (CDSCO). Parameters assessed were number of medicines in NLEMs 2015 and 2022, therapeutic category-wise additions and deletions in 2022, Fixed dose combinations (FDCs) included in NLEM 2022, Antibiotics in NLEM 2022 as per the WHO Access, Watch and Reserve (AWaRe) classification. Results: 384 medicines have been included in NLEM 2022. Major changes were done in the anti-infective therapeutic category in which 18 out of 34 (53%) medicines were added and 9 out of 26 (34%) medicines were deleted. Only 22 FDCs are included in the...
Read More
Posted by admin on Oct 31, 2024 in |
Background and Aim: The Amaranthaceae family have gained attention for their potential antiulcer properties. Peptic ulcers, a prevalent gastrointestinal disorder, necessitate the exploration of alternative therapies, and Amaranthaceae species may offer promising leads in this regard. Therefore, we have selected Amaranthus spinosus from the Amaranthaceae family for the evaluation of antioxidant and antiulcer properties. Method: The plant material was successively extracted by the Soxhlet extraction technique with Petroleum ether, chloroform, methanol, and water. The antioxidant activity of the plant extracts and the standard drugs were based on consideration of the radical scavenging influence of the stable “1,1-diphenyl-2-picrylhydrazyl” (DPPH) free radical action and hydrogen peroxide process. Two models, and non-steroidal anti-inflammatory induced ulcer and pyloric ligation, were analysed for methanolic extract of Amaranthus spinosus for its antiulcer activity. Result: The phytochemical examination of methanolic extracts reveals the presence of triterpenoids, flavonoids, alkaloids, tannins, glycosides, and proteins. The antioxidant study results revealed that among all the four extracts, the MEAS possesses significant antioxidant potential. Compared with control, there were a significant...
Read More
Posted by admin on Oct 31, 2024 in |
The prevalence of Rheumatoid Arthritis is 0.1% to 1% and it is most common in developed countries. More than 2/3rd [54%-70%] of patients with RA have sleep disturbances. In RA multiple episodes of inflammation are predictive of an increased risk of developing depression. The prevalence of depression in individual RA ranges 14% to 48%. Sleep disturbances & depression in those with RA patients worsen their quality of life and impair their daily activity. Sleep issues and depressions have the potential to disrupt the effectiveness of treatments for RA. By addressing their concerns, we can enhance treatment compliance. There is a bidirectional relationship between RA, sleep disturbance & depression, poor sleep and depression can worsen RA symptoms. Understanding this complex scenario is crucial for the comprehensive care. Identifying and addressing sleep problems & depression can lead to better management strategies. These may involve lifestyle changes medication adjustments or mental health interventions to improve both physical & emotional well-being. This study is essential for enhancing their wellbeing, optimizing treatment outcomes and...
Read More
