Posted by admin on Jun 30, 2024 in |
A new, simple, and sensitive differential scanning calorimetry and infrared spectrophotometric technique was developed to estimate ethambutol hydrochloride in tablet dosage form. In the first method the concentration range of ethambutol hydrochloride was discovered to be 0.5 mg to 2.0 mg using differential scanning calorimetry (DSC), with the peak region of an exothermic thermogram at 75.8 °C and a continuous heating rate of 5 °K min-1. Second method which involves the measurement of ethambutol hydrochloride by Infra Red (IR) spectroscopy, the concentration range was determined to be 1.0 mg to 2.5 mg. The correlation coefficients for these techniques were determined to be 0.999 and 0.9919 for both DSC and IR methods respectively. The analytical results were statistically validated by the ANOVA technique and recovery trials. The recovery trials show no influence from other chemicals in the formulation. As a result, these two procedures are easy, precise, accurate and specific, and they might be employed for regular...
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Posted by admin on Jun 30, 2024 in |
The escalating use of medications among children presents a global concern, with self-medication by parents increasingly prevalent. This study investigates the prevalence of self-medication practices among parents of children aged 1 to 12. Methods: Over six months, 200 participants who self-medicated their sick children were enrolled. The study, conducted at King Koti District Hospital in Hyderabad, utilized a self-structured questionnaire targeting paediatric patients aged 0-12. Results: Most participants were parents aged 20 to 40 years, predominantly fathers (65.5%), with most having two children (36%) aged 2-4 years. Fever was the most commonly reported condition (22.5%). While a significant proportion expressed confidence in selecting over-the-counter (OTC) medications (41.5%), NSAIDs and analgesics were the primary choices. Safety perceptions varied, with 25% considering OTC medications generally safe and 13% entirely safe. Discussion: The study highlights parental awareness of risks associated with self-medication, notably allergic reactions (49.5%) and over dosage (57%). It provides insights into parental self-medication practices in paediatric care, emphasizing the need for tailored interventions and educational efforts on safe medication...
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Posted by admin on Jun 30, 2024 in |
Aim: This study aims to explore the potential of transdermal drug administration as a viable alternative to conventional medication delivery systems. Specifically, the focus is on the development and evaluation of transdermal patches containing Lamivudine and Stavudine for the treatment of AIDS. The overarching objectives include extending drug release duration, reducing administration frequency, and enhancing patient compliance. Material & Methods: The formulations under investigation are meticulously designed using a combination of HPMCK15M, PVPK30, and EC in varying ratios. The patches are subjected to a thorough assessment, encompassing critical parameters such as film thickness, tensile strength, and drug content homogeneity. The incorporation of Tween 80 and dimethyl sulfoxide as plasticizer and penetration enhancer is a key methodological consideration for optimizing the transdermal patches. Additionally, the study explores the impact of natural permeation enhancers, such as oleic acid, eucalyptus oil, and clove oil, on drug permeation and release kinetics. Results: The outcomes of the study reveal promising findings, with the transdermal patches exhibiting favorable characteristics, including optimal film thickness, tensile strength,...
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Posted by admin on Jun 30, 2024 in |
The present study aimed to evaluate the effect of hydroalcoholic extract of Sida spinosa L. (HYSS) in antigen induced rheumatoid arthritis in mice by intra articular administration of Bovine serum. Rheumatoid arthritis was induced by the mixture of antigen (Bovine serum albumin) and adjuvant (Imject alum) in 1:1 ratio on 1st, 7th and 21st day as an induction period. The mixture of antigen and adjuvant caused the joint destruction, chronic inflammation of synovium, pannus formation, erosion of bones and cartilage in mice. The HYSS administered at three different concentrations 100, 200 and 400 mg/kg,p.o. as test and Indomethacin (2 mg/kg, p.o) as reference standard for next 20 days as a treatment period in arthritis induced mice. The study was conducted for total 41 consecutive days as initial 21 days of induction and next 20 days as treatment period. Progression of arthritis in different group of animals was evaluated by biochemical parameters, histological changes, antioxidant activity and radiographic analysis in overall joint structure. HYSS at 200 and 400 mg/kg significantly...
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Posted by admin on Jun 30, 2024 in |
Sagadevi nei is a Siddha polyherbal formulation indicated for Neerkattu and Neersurukku. The main ingredient of the formulation is Vernonia cinerea, belonging to the family Fabaceae, which has been proven scientifically to exhibit renal tubular regrowth. Based on Literature, each ingredient of the mixture has nephroprotective, diuretic, antioxidant, and anti-inflammatory properties. Cisplatin is a metallic compound antineoplastic drug with a known side effect of renal damage. The present study aims to elucidate the attenuative effect of Sagadevi Nei against Nephrotoxicity. MTT assay is a sensitive and reliable indicator of cellular metabolic activity. This study is done in-vitro by MTT assay in Human Embryonic Kidney (HEK) 293 cell lines. The toxicity was induced by cisplatin and the amount of cell damage was calculated. The Nephroprotective activity assessed by MTT Assay against cisplatin-treated HEK293 Cell lines co-treated with Sagadevi Nei showed an increase in the percentage of cell viability from 49.82% to 67.87% in a dose-dependent...
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