Posted by admin on Sep 30, 2019 in |
The present study investigates the wound healing activity of ethanolic extract of the fruit of Luffa acutangula. The medicinal values of the Luffa acutangula have been mentioned ancient literature as useful in disorders of wound. Dried fruits of Luffa acutangula were powdered and extracted with ethanol using soxhlation method. Ethanolic extract of Luffa acutangula was evaluated for its wound healing activity in rats using excision wound model with help of Plethysmometer. Soframycin used as a standard drug. For this activity test groups received ethanolic fruit extract of Luffa acutangula. Results showed that in excision wound healing model, animals of standard treated and drug-treated (treated with ethanolic extract of Luffa acutangula) groups showed significant decrease in wound contraction ability, epithelialization period when compared to animals of normal...
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Posted by admin on Sep 30, 2019 in |
Present work is aimed at development and characterization of phytosomes, novel drug delivery dosage form used to improve the bioavailability of the drug, containing ethanolic, aqueous, dichloromethane and ethyl acetate extract of Citrullus colocynthis to meet the need for better effectiveness and safety. Required phytosomal formulations were developed using different extracts of Citrullus colocynthis and phytosomes formed from the lecithin and cholesterol, then characterized. Characterization involved various parameters, such as Particle size determination, apparent solubility, entrapment efficiency, Scanning Electron Microscope, Fourier-Transform Infrared Spectroscopy, X-ray Diffraction (XRD), and dissolution study (in-vitro drug release). Particle size varied from 250 nm to 0.1 µm depending on the extract. The mean particle size of phytosomal complex of DCM extract of CC was scattered in a narrow range of 254 ± 20.0 nm, and polydispersity index was 0.857 ± 0.055, where phytosomal formulation of DCM extract shows better entrapment then other phytosomal formulation. Photomicrographs revealed that phytosomes were spherical in shape and uniform in...
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Posted by admin on Sep 30, 2019 in |
Metabolic syndrome is a group of several clinical conditions which is related to the prevalence of another disease such as cardiovascular disease, diabetes mellitus (DM) or increased fasting blood glucose level, visceral obesity, hypertension, etc. The major factor that affects the metabolic syndrome occurrence is diet composition.This research aimed to determine the influence of diet composition on metabolic syndrome prevalence. This study was performed using in-vivo method. The animal was divided into three groups, each administered a different composition of diet, which was high carbohydrate, high lipid, and high protein diet for 42 days. The parameters were body weight, HDL and triglyceride level, blood glucose level, and blood pressure. The results showed that each diet composition affected the glucose, HDL, triglyceride, and blood pressure level differently. The high-fat diet gave the most significant effect in HDL reducing and blood pressure elevation, while the high carbohydrate diet gave the most significant effect in blood glucose and triglyceride level elevation. It could be concluded that the lowest affecting food to metabolic...
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Posted by admin on Sep 30, 2019 in |
Cyclic imides such as succinimides, maleimides, phthalimide and their derivatives contain an imide ring and a general structure –CO-N(R)-CO- that confers hydrophobicity and neutral nature. Succinimide (pyrolidine 2,5-dione) is a synthetically versatile substrate used for the synthesis of heterocyclic compounds and as a raw material for drug synthesis. Derivatives of succinimide are of important biological and pharmaceutical uses such as antibacterial, antifungal, anticonvulsant, antitumor and antinociceptive. In spite of these activities, much of their action mechanisms at molecular and cellular levels remain to be elucidated. A new series of nickel(II) and copper(II) complexes of a new mannichbase1-((2,5-dioxopyrrolidin-1-yl)(4-methoxyphenyl) methyl) thiourea (LIGAND) have been synthesized. The structures of newly synthesized compounds have been explicated on the basis of elemental analysis, molar conductance, IR, UV-Visible, NMR, Mass, and Magnetic measurements. The binding of the copper sulfate complex of the ligand with calf thymus DNA has been investigated using absorption spectroscopy, fluorescence spectroscopy, and viscosity...
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Posted by admin on Sep 30, 2019 in |
Aim of the present study was to evaluate the antianxiety and antidepressant activity of Valeriana pyrolaefolia, a member of family Valerianaceae. The antianxiety and antidepressant activities of dichloromethane extract were evaluated using the elevated plus-maze model and porsolt’s despair swim test. The studies were conducted on lacca mice, and the test materials were administered per oral route. The dichloromethane extract of V. pyrolaefolia roots exhibited significant dose-dependent antianxiety activity at 400 mg/kg. The results were comparable to the standard diazepam (2 mg/kg). The extract also exhibited significant antidepressant activity at 400 mg/kg dose. The results were comparable to the standard imipramine (10 mg/kg). The TLC fingerprint profile of the bioactive extract was developed using precoated TLC plates of 0.2 mm thickness. Valtrate was used as a bioactive marker for developing TLC fingerprint profile. The solvent system comprising dichloromethane: ethyl methyl ketone (8: 2) was used for developing the TLC profile. The TL chromatogram showed valtrate as a major component of the...
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