Posted by admin on Jul 31, 2019 in |
Introduction: Type 2 diabetes, which is the most common type, is often a result of excess body weight and physical inactivity in genetically predisposed individuals. Over due course of time diabetes can cause blindness, kidney damage, neurological problems, and coronary artery disease. Improvement in glycemic control is important factors in delaying the onset and progression of diabetes-related complications. In spite of the availability of newer antidiabetic drugs, prevention of complication is still a challenge. Nishamalaki, Patoladi Yoga and Shobhanjan are the Ayurvedic formulations claimed to be effective in preventing nephrotoxicity. Objective: To evaluate the therapeutic efficacy of Nishamalaki, Patoladi Yoga, and Shobhanjan in diabetic nephropathy. Materials and Methods: Total of 36 Wistar rats were used for the study. Diabetes was induced in 30 Wistar rats of either sex with STZ (35 mg/kg) i.p followed by High Fat High Fructose diet (HFHF), (coconut oil+ vanaspati) till the development of Diabetic nephropathy (10wks) which was confirmed by Sr. creatinine, blood urea levels. Out of six groups included in the study, group...
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Posted by admin on Jul 31, 2019 in |
This work aimed to evaluate the quality of some commercial peppermint oil products available in the Egyptian market. Also, analysis of peppermint oil extracted from Mentha piperita L. leaves marketed in Egypt. Thus, quality control of both herb extracted and purchased oil products. Essential oils were analyzed using GC/MS, and the main ingredients of each peppermint oil sample were quantified. The antioxidant potential for each of the tested six oil samples was performed using the DPPH radical scavenging assay using ascorbic acid as a reference standard. Also, their EC50% values were calculated. The quality of the samples had been evaluated according to the European Pharmacopeia limits for each of the major peppermint oil components. Thus, menthol, menthone, menthyl acetate, carvone, and pulegone percent composition in each sample was used to evaluate its quality. All the tested samples were found to possess strong to moderate antioxidant activities with EC50% values ranged from 20.44 and 66.10 depending on the oil chemical composition variation. Percent composition of the major peppermint oil components...
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Posted by admin on Jul 31, 2019 in |
The present research work was considered to achieve preliminary phytochemical screening, acute oral toxicity, antioxidant activity, and to evaluate the antihyperlipidemic property of the aqueous and ethanolic extracts of leaves of Amaranthus tricolor. Antioxidant activities of the aqueous and ethanolic extracts of leaves of Amaranthus tricolor were investigated by Free Radical Scavenging Activity (DPPH method) and antihyperlipidemic activity by in-vivo effects on an atherogenic diet (2% cholesterol, 1% choline chloride and 2% Lard) induced rats hyperlipidemia. Our results exposed that Amaranthus tricolor showed potent antioxidant properties. In the cholesterol-induced hyperlipidemic model, groups of rats treated with extracts A. tricolor showed a significant reduction in total cholesterol (TC), triglycerides (TG) and in levels of SGOT, SGPT, ALP, LDH, and CKMB activities whereas increase in the level of high-density lipoprotein (HDL) compared to cholesterol-induced hyperlipidemic control group at dose-dependent manner but the effect was less than the standard drug Atorvastatin. It was observed from the histopathological findings that rats fed with A. tricolor extracts showed a decrease in granular degeneration caused...
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Posted by admin on Jul 31, 2019 in |
Background: Cisplatin is active cytotoxic agents in the treatment of cancer and has many adverse side effects, including hepatotoxicity. Honey and royal jelly are natural products and having antioxidants properties. Aim of the study: To investigate the protective role of combined administration of honey and royal jelly against cisplatin-induced changes in biomarkers of oxidative stress in rat liver. Materials and methods: Male Wistar albino rats of approximately the same age and weight were randomly divided into four groups. Group I: rats were controlled and were given 0.9% saline. Group II; rats were injected cisplatin (7 mg/kg/day) intraperitoneally for 15 days. Group III; rats were fed orally honey (500 mg/kg/day) with royal jelly (100 mg/kg/day) for 15 days. Group IV; rats have injected cisplatin (7 mg/kg/day) intraperitoneally and fed orally honey (500 mg/kg/day) with royal jelly (100 mg/kg/day) daily for 15 days. At the end of experimental animals were deprived of food overnight and sacrificed by cervical decapitation for estimation of antioxidant enzyme in liver tissue. Results: Administration of cisplatin...
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Posted by admin on Jul 31, 2019 in |
A simple, specific, accurate reversed-phase high performance liquid chromatographic method was developed for the quantification of Cabozantinib. Although extensive studies on Cabozantinib have been developed for determining Cabozantinib in human place and urine by LC-MS, studies on the pharmaceutically active ingredient and formulation are scarce. The effective separation was achieved through BDS C18 150 × 4.6 mm, 5m using a mobile phase KH2PO4 Buffer and ACN (55:45% v/v). The flow rate of the mobile phase was 1.0 mL/min, and the detection was carried at a wavelength of 210 nm. The retention time of Cabozantinib was 2.932 nm. The correlation coefficient is 0.9998. The developed method was validated in terms of system suitability, specificity, linearity range, precision, accuracy, limits of detection and quantification. Degradation studies were performed on Cabozantinib to indicate the stability property and specificity of the proposed method. The information presented in this study will be useful for industrial application for determining Cabozantinib in active pharmaceutical ingredient and pharmaceutical dosage...
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