Posted by admin on Apr 30, 2019 in |
Nymphoides hydrophylla (NH) is mainly an aquatic herb of Menynthaceae family and traditionally used to treat fever, insect bites, different ulcers, and also to wash skin, where parasitic affection occurs. In this study, methanolic extract of Nymphoides hydrophylla (NH) plant was examined for the determination of thrombolytic, antipyretic, Central Nervous System (CNS) and analgesic activities. The evaluation of thrombolytic potential, antipyretic, CNS and analgesic activities of the plant extract occurred by their clot lysis, temperature reducing, and depression-inducing and pain sensation decreasing ability respectively. The result from the study showed the thrombolytic activity 3.05 ± 0.70% to 26.45 ± 2.18% indicating the better thrombolytic activity at a lower dose. The maximum pyrexia suppression of 91.07% is observed for 400 mg/kg NH extract. In hole cross and open field tests, maximum 71.42% and 66.80% suppression of locomotor activity were observed with the methanolic NH extract (400 mg/kg) whereas suppression of the locomotor activity of the standard drug diazepam was 68.57% and 51.20% respectively. From the analgesic data, about 91.72% inhibition...
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Posted by admin on Apr 30, 2019 in |
BCS class II drugs usually suffer inadequate bioavailability as a dissolution step is the absorption rate-limiting step. In this work, the effect of solubility increase at the main absorption site for these drugs was investigated using ritonavir as a drug model. The liquidsolid technique was applied to prepare ritonavir per-oral tablets of high dissolution rate using versatile non-ionic surfactants of high solubilizing ability [Transcutol HP, labrasol and labrasol/labrafil (1:1) mixture] as liquid vehicles at different drug concentrations (10–30%) and fixed (R). The prepared liquisolid tablets were fully evaluated, and the dissolution rate at pH 1.2 was investigated. The formula of higher dissolution rate was subjected to solid state characterization using Differential Scanning Calorimetric (DSC), Infrared Spectroscopy (IR). Results showed that liquisolid tablet prepared using labrasol/labrafil (1:1) mixture as a liquid vehicle containing 10% ritonavir is a compatible formula with a higher dissolution rate (100% in 35 min). This led to the conclusion that liquisolid technique efficiently improved the drug solubility and dissolution rate of BCS class II...
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Posted by admin on Apr 30, 2019 in |
This study aims to assess the preventive effects of green tea infusion and epicatechin on doxorubicin (Dox)-induced kidney and heart injuries and oxidative stress in male Wistar rats. The male Wistar rats administered Dox at an intraperitoneal dose of 4 mg/kg body weight (b.w.)/ week were orally treated with green tea infusion (200 mg/kg b.w.) and epicatechin (25 mg/kg b.w.) every other day for 6 weeks. The treatments of Dox-administered rats with green tea infusion and epicatechin resulted in a significant decrease in the elevated serum creatinine, urea and uric acid levels reflecting an improvement in kidney function. Similarly, the elevated serum CK-MB, LDH and AST activities were significantly ameliorated as a result of treatments of Dox-administered rats, thereby manifesting an amendment of heart function. The treatments also led to the prevention of the elevated lipid peroxidation and amelioration of the lowered GPx and GST activities as well as GSH content in kidney and heart. However, the SOD activity was not significantly altered in kidney and heart as a...
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Posted by admin on Apr 30, 2019 in |
Purpose: To evaluate parent’s attitude towards childhood vaccination and to determine the factors associated with non-adherence of parents to the mandatory vaccination schedule in Sungai Petani, Kedah, Malaysia. Methods: a Validated questionnaire was used as an instrument for evaluating parent’s attitude regarding childhood vaccination. Data obtained was classified based on Bloom’s cut-off point for determining parents’ attitude. For the analysis of data SPSS version 20 was used and P-value of <0.05 was considered statistically significant. Results: a total of 396 parent’s attitude was evaluated for obtaining different factors associated with the unscheduled vaccination. A significant difference was observed in parents attitude based on gender (P-value = 0.0.21). It was found that parent’s income has a prominent impact on the parent’s attitude and can be considered as a potential barrier in the provision of proper immunization of children against fatal diseases (Ф= 0.329, P-value <0.001). By education level, parents in the postgraduate level of education were having a good attitude (SD ± 4.15, Mean Rank = 39.01) in comparison to...
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Posted by admin on Apr 30, 2019 in |
Use of plants as a source of medicine has been inherited and is an important component of the health care system in India. Tridax procumbens Linn. (Asteraceae) one of the medicinally important plants commonly found in subtropical countries growing primarily at waste places, roadsides throughout India during the raining season was chromatographically evaluated in the present work for various phytochemicals found in it. The phytochemical tests showed the presence of alkaloids, flavonoids, phenols, saponins, steroids, tannins in methanolic extract of Tridax procumbens (METP). Majorly 25 compounds found in 82.81% peak area were identified through spectrum matching with National Institute Standard and Technology (NIST) database. As per known effects of the observed compounds like octadecanoic acid, 11, 14, 17- Eicosatrienoic acid, methyl ester, 9, 12, 15-Octa-decatrienoic acid, methyl ester (Z,Z,Z,)-, phthalic acid, 6-Methylhept-2-Yl-Tridecyl ester the T. procumbens reflected some novel therapeutic effects like anti-microbial, anti-cancer, anti-hair fall, CNS depressant, analgesic, anti-inflammatory, antipyretic, anti-arthritic, anti-coronary, anti-neoplastic, immunosuppressive, anti-spermatogenic activity. Furthermore, identification and purification of the active compounds responsible for the therapeutic...
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