Posted by admin on May 31, 2019 in |
Objective: The prodigious challenge in the pharmaceutical industries was to enhance the solubility and the permeability of those drugs as key factors to improve their bioavailability. Various techniques have been used to improve the drug water solubility and release profile, and solid dispersions are considered to be the most successful techniques. The aim of the present study was to improve the solubility and bioavailability of a poorly water-soluble antihypertensive drug (Eprosartan) in the human body, using a solid dispersion technique (hot melt extrusion) and comparison with other methods. Methods: The development of solid dispersions as a practically viable method to enhance the bioavailability of poorly water-soluble drugs to overcome the limitations of previous approaches such as salt formation, solubilization by co-solvents and particle size reduction studies revealed that drugs in solid dispersion need not necessarily exist in the micronized state. Solid solution was prepared by solvent evaporation, fusion method, hot melt extrusion technique at 1:1.1, 1:2 (Eprosartan: Soluplus) and 1:1.5:0.5 (Eprosartan:Soluplus: Kollidan/Plasdone) ratios respectively. Solid Solution was evaluated for...
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Posted by admin on May 31, 2019 in |
The purpose of the present study was to formulate Losartan potassium compression-coated tablets using okra gum as a binder along with synthetic hydrophilic polymers like various grades of Hydroxypropyl methylcellulose (HPMC) and compare the different parameters. The effect of different concentration of okra is to be used in the formulations with varying concentration of the polymers, elucidating the effect of type of polymers and its concentration on release pattern of the drug from the compression-coated tablets. Okra gum was extracted by using acetone. After subsequent evaluation of the gum and the preformulation studies of the drug, fast disintegrating core tablets were prepared. Okra gum was used as binder in varied concentrations (3%, 4% & 5%) and three different grades of Hydroxypropyl methylcellulose (HPMC) were used in 30%, 60% & 90% concentrations to prepare compression coated tablets. Characterization was done, and the drug release pattern was compared among the batches. Preformulation studies like differential scanning calorimeter (DSC), Fourier transform infrared spectroscopy (FTIR) showed that there was no significant interaction between the...
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Posted by admin on May 31, 2019 in |
The aim of the present work is the evaluation of anticancer activity of Duranta erecta L. stem extracts and also an investigation of the phytoconstituents from the different extracts of the plant. Chloroform, ethyl acetate, methanol and aqueous extracts of Duranta erecta L. stem were tested for their anticancer activity on three cancer cell lines, i.e., MCF-7 (Breast), HL-60 (Leukemia), and HT-29 (Colon) at various concentrations. The anticancer effect of the extracts on cell inhibition was studied using Sulphorhodamine B assay. Chloroform, ethyl acetate, and methanolic extracts showed the dose-dependent anticancer effect on leukemia cancer cells, but these extracts were inactive against breast and colon cancer cell lines. The aqueous extract was inactive against all three cell lines. Phytochemical profile of the plant extracts proves the presence of flavonoid, alkaloids, saponins, tannins, and triterpenes. The result suggested that chloroform, ethyl acetate and methanolic extracts of Duranta erecta L. contains some important chemical constituents, which can be further used in the treatment of...
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Posted by admin on May 31, 2019 in |
Fast dissolving tablets are those which disintegrates rapidly within the mouth and taken without consumption of water. The present work is concerned with the formulation and in-vitro evaluation of Lacosamide fast dissolving tablets. Lacosamide is a novel anti-epileptic drug used in the treatment of partial onset of seizures. The objective of this study was to improve the rapid onset of action of the drug. The fast dissolving tablets of Lacosamide were prepared using direct compression method by employing natural super- disintegrating agents like dehydrated banana powder (DBP) and Ocimum sanctum powder. Different concentrations of superdisintegrants were used in the formulations as 2%, 4%, 6%, and 8%. The prepared tablets were evaluated for pre-compression parameters like bulk density, tapped density, angle of repose, Hausner ratio, Carr’s index, and were in the acceptable range. Post-compression parameters like hardness, friability, drug content, wetting time, water absorption ratio, disintegration time, and dissolution study were also evaluated. From the results obtained, it was found that tablet formulation with 8% concentration of Ocimum sanctum seed...
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Posted by admin on May 31, 2019 in |
Eurycomanone from the roots of Eurycoma longifolia Jack (ELJ) has been reported to exhibit anticancer activity. Four of ester eurycomanone derivatives: eurycomanone dibutyrate, eurycomanone monovalerate, eurycomanone dimethoxybenzene, and eurycomanone disuccinate were synthesized for knowing their activities on cancer cell lines T47D, MCF-7, Hela, WIDR and Vero cells. The cancer activity was evaluated by the MTT colorimetric assay method. The results showed that eurycomanone has anticancer activity on T47D, MCF-7, Hela, WIDR cancer cells with IC50 values (1.17 ± 0.09; 3.96 ± 0.02; 2.95 ± 0.08; 1.45 ± 0.01 µg/mL), and no toxic to Vero cells (609.89 ± 29.77 µg/mL). Its derivatives eurycomanone dibutyrate have anticancer activity on T47D, MCF-7, Hela, WIDR cancer cells with IC50 values (25.16 ± 2.25; 21.56 ± 4.55; 29.32 ± 1.25; 149.42 ± 12.50µg/mL), eurycomanone monovalerate (25.59 ± 1.31; 22.48 ± 1.25; 30.14 ± 1.89; 91.88 ± 8.90 µg/mL), eurycomanone dimethoxybenzene ( 102.77 ± 2.56; 38.83 ± 2.55; 66.65 ± 1.90; 51.61 ± 2.37µg/mL), eurycomanone disuccinate (218.94 ± 9.30; 198.87 ± 5.50; 166.67 ± 12.34;...
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