Posted by admin on Apr 30, 2019 in |
Introduction: Schizophrenia is a chronic and debilitating psychiatric illness affecting around 0.4% to 1.4% of people at some point in their life. Early onset and the chronic course make schizophrenia a worrying disease. Prescribing pattern in Schizophrenia has seen a significant shift in the last two decades, from the first generation to second-generation antipsychotics. This study was carried out to analyze the pattern of antipsychotic drug utilization in patients of schizophrenia presenting at an outpatient department of a tertiary hospital. Materials and Methods: A cross-sectional observational study was conducted at the psychiatry outpatient department of a tertiary care hospital for six months. Diagnosis of Schizophrenia was made according to DSM – 5 criteria. Prescriptions were analyzed for demographic details, and the psychotropic prescribing pattern was studied using WHO indicators. Results: Amongst 104 prescriptions, 59.61% were males, and 68.20% of study subjects were below 40 years. 95.96% prescriptions were of atypical antipsychotics, Risperidone being the most commonly prescribed (52.88%), followed by Olanzapine (28.84%). Antipsychotic polypharmacy was noted in 19.23% of...
Read More
Posted by admin on Apr 30, 2019 in |
The main objective was to study the prescribing pattern of antibiotic in a tertiary care hospital to assess the frequency and prescribing the practice of antibiotics. The study includes an observational study of antibiotic prescribing patterns conducted over 6 months. In this study, enrolled 300 patients who were prescribed with antibiotics from both outpatient and inpatient department. Data were collected from the patient’s chart and was subjected to analyze by performing descriptive statistics. In the present study, the prescription was assessed and found the maximum number of patients belonged to the age group of 21-30 years, and the proportion of male patients was more compared to the female patients. Moreover, younger and adult patients were commonly associated with the highest prescribed antibiotics in both male and female patients. Also observed that the frequency of antibiotics were 1, 2, and 3 or > 3 prescribed to 55%, 26%, and 19% respectively. Among the all group of antibiotics cephalosporins was found to be prescribed to the largest number (22.03%) of patients,...
Read More
Posted by admin on Apr 30, 2019 in |
Mucositis is a foremost acute complication in the clinical setting, occurring in a large percentage of patients undergoing cytotoxic therapy. One of the major problems with mucositis is that the underlying mechanisms behind its development are not wholly understood, which makes it extremely difficult to develop effective interventions. Animal models provide a critical source of knowledge when sampling from patients is unavailable, or interventions are yet to be fully tested. The object of the study is to evaluate the potential effectiveness of optimized L-glutamine hydrogel formulation used in the buccal cavity; we used a rat model for oral mucositis induced by 5-fluorouracil. Studies have shown that the blend of mild abrasion of the cheek pouch and two doses of 5-fluorouracil (60- 40 mg/kg) induced oral mucositis and the reduction of body weight. Optimized hydrogel formulations CP4 and GSH14 shown significant weight gain as compared to the control group. This study shows that the prepared hydrogel is effective in oral mucositis and effective to control oral mucositis. The rationale selection...
Read More
Posted by admin on Apr 30, 2019 in |
In present work, the gold nanoparticles have been prepared through green synthesis using maize extract at room temperature, the maize extract was used as reducing and stabilizing agents for AuNPs (gold nanoparticles), synthesized gold nanoparticles were confirmed by the color change of the aqueous solution, and the PH of the solution was 7.8, after the confirmation, green gold nanoparticles were characterized through various techniques like UV-Visible spectroscopy, FT-IR (Fourier Transform Infrared Spectroscopy), SEM (Scanning Electron Microscopy), TEM (Transmission Electron Microscopy) and EDAX (Energy Dispersive X-ray analysis). UV- Visible spectroscopy was used to determine the green gold nanoparticles, the absorbance peak was observed at 540 nm with the spherical sized gold nanoparticles, and green gold nanoparticles were also confirmed by TEM, and average particle size of gold nanoparticles was observed 30 nm. FT-IR results represent the various phenolic compounds like alkaloids and flavonoids in aqueous solution. The size, shape and other properties were confirmed through Scanning Electron Microscopy and EDAX analysis. Green synthesis of the gold nanoparticles at room temperature...
Read More
Posted by admin on Apr 30, 2019 in |
Introduction: Melasma is a common facial pigmentary dermatosis in Indians. In spite of various treatment modalities, treatment of melasma is often challenging and recalcitrant. In this context, the present study was carried out to elucidate efficacy and safety of topical 10% Tranexamic acid (TXA) in melasma treatment. Materials and Methods: 40 Melasma patients with malar type were enrolled in the 12 weeks study. They were advised to apply 10% Tranexamic acid cream and placebo to the right and left cheek respectively along with sunscreen. MASI score, a subjective measurement was determined as a clinical outcome of study before and after treatment. Results: After treatment, there was a statistically significant reduction of baseline mean MASI score (Melasma Area and Severity Index score) of the right side of cheek (Tranexamic acid) 5.12 ± 1.78 to 4.01 ± 1.51 (P=0.000). Patient and physician satisfaction score revealed good response in the majority of the study population. Conclusion: Topical 10% Tranexamic acid is effective and safe for melasma...
Read More
