Posted by admin on Jul 31, 2019 in |
The most striking feature of natural products in connection to their long-lasting importance in drug discovery is their structural diversity that is still largely untapped. Most natural products are not only sterically more complex than synthetic compounds but also differ in regards to the statistical distribution of functionalities. The chemical diversity and unique biological activities of a wide variety of natural products have propelled many discoveries in chemical and biological sciences and provided therapeutic agents to treat various diseases as well as offered leads for the development of valuable medicines. The present study has been designed to screen the phytochemicals and to evaluate the antibacterial potential of Nigella sativa L. seeds against ESBL positive Escherichia coli isolates. The crude extracts of Nigella sativa L. seeds were prepared by utilizing two methods namely Soxhlet extraction and Supercritical Fluid Carbon dioxide (SCFE-CO2) extraction. Preliminary phytochemical analysis revealed the presence of alkaloids, flavonoids, phenols, tannins, saponins, and terpenoids which are known to exhibit medicinal as well as physiological activities. The Supercritical Fluid...
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Posted by admin on Jul 31, 2019 in |
Ethanol extracts of rambutan leaves have been investigated for their anti-diabetes properties using the glucose tolerance method as well as insulin deficiency through alloxan induction. This study aimed to further evaluate these properties in obese and insulin resistant animals. The rat models were feeding with foods high in carbohydrates, fats, and propylthiouracil. The animal models were divided into seven groups: normal group, the positive control group, rambutan leaf extract at doses of 17.5, 35, and 70 mg/kg b.w., and the orlistat and metformin groups. The parameters evaluated during therapy were body weight, food index, feces index, and blood glucose levels. The rambutan leaf ethanol extract at a dose of 17.5 mg/kg b.w. resulted in a decrease in body weight by 2.44% compared to the initial body weight and could also decrease appetite with the amount of food intake equal to 10.71 g compared with the positive test group at 12.49 g. The rats administered 35 mg/kg b.w. rambutan leaf ethanol extract excreted 6.29g of feces and exhibited a decreased...
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Posted by admin on Jul 31, 2019 in |
The objective of the study was to determine the phytochemicals present in the leaf extracts of Diospyros blancoi A. DC and to evaluate its antioxidant and antidiabetic activities. Qualitative phytochemical tests were used to detect the presence of bioactive compounds present in leaf extracts of D. blancoi. Antioxidant activity was measured through diphenyl-1-picrylhydrazyl assay, and antidiabetic potential was done using alloxan induced white mice. Based on the results, the following bioactive constituents are present in the leaves: alkaloids, flavonoids, tannins, terpenoids, saponins, anthraquinones, steroids, and glycosides in both ethanol and water extracts of D. blancoi. Moreover, results showed that the ethanolic extract had better antioxidant activity compared to water extract. Furthermore, results also showed that both ethanolic and waterleaf extracts had significant antidiabetic effects to alloxan-induced diabetic white mice as shown in their ability to reduce blood glucose level. Results indicate that extracts of D. blancoi leaves are potential sources of natural antioxidant and antidiabetic compounds and could have potential use in the management of...
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Posted by admin on Jul 31, 2019 in |
Clopidogrel bisulphate (CB) is the rate of dissolution often controls a sparingly soluble orally administered drug and the rate of absorption. Reports suggest that the drug has poor water solubility which may be challenging for developing liquid dosage forms of Clopidogrel bisulphate. Hence in the present study, we sought to develop orodispersible nanoparticles to enhance the solubility by an anti-solvent evaporation technique using stabilizers as PVPK-30, Poloxamer-188, PVA, L-arginine and tween-80. We found that the particle size was ranging between 154.7 nm to 844.2 nm and % Drug entrapment efficiency was 42.4% to 97.1% respectively. Among all the formulations, F3 stabilized with L-arginine and PVA has been found to show 92.62 ± 0.81% drug release at the end of 10 min in both 0.1N HCl and phosphate buffer (pH6.8). Through SEM studies we found that the particles were small with no aggregation. Further, the particles (F3) were compressed into tablets F3(c) through direct compression method and characterized based on some selected parameters in comparison with the marketed tablet. We...
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Posted by admin on Jul 31, 2019 in |
Fragaria ananassa fruit are small shrubs belonging to family rosaceae. Fragaria ananassa mainly contains anti-oxidants such as tocopherols, ascorbic acid and b-carotene which are effective against cancer, heart disease and cataracts. The focus of the study was toanalyze the diuretic activity of hydro alcoholic extract of Fragaria ananassa fruit in albino rats. Diuretic activity of hydroalcoholic (70:30) extract of Fragaria ananassa fruit (100mg/kg and 200mg/kg body weight orally) was studied in male wistar albino rats (n=5).Group I Serve as control receive 1% CMC solution, Group II serve as standard receive Furosemide 10mg/kg, Group III receive 100mg/kg Fragaria ananassa and Group IV receive 200mg/kg Urine volume at various interval was measured using metabolic cages (Lipschitz Method). The concentration of Na+, K+ in the urine at the end of 24 hours was estimated using flame photometer. One-way ANOVA technique was used for statically data analysis by which was followed by Dunnet t test (Graph Pad Prism software). On the basis of analysis, it was found that hydroalcoholic extract of Fragaria ananassa...
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