Posted by admin on Apr 30, 2019 in |
An accurate and precise HPLC method was developed and validated for simultaneous determination of Levocetirizine dihydrochloride, Phenylephrine hydrochloride and Paracetamol in syrup formulations. The separation between Levocetirizine dihydrochloride, Phenylephrine hydrochloride, and Paracetamol was achieved within 20 min using an L1 column of 100 × 4.6 mm, 3 µ dimension using gradient programme and detector wavelength 215 nm. The mobile phase solution A is a buffer solution of 0.015 Molar 1-octane sulphonic acid sodium salt adjusted pH 3.4 with orthophosphoric acid and mobile phase solution B is Acetonitrile. The Method was validated as per ICH guideline for parameters like Specificity, Precision, Accuracy, solution stability, filter compatibility, and robustness. Accuracy for Levocetirizine dihydrochloride, Phenylephrine hydrochloride, and Paracetamol lies between 97.0 to 103.0%. The proposed method can be used for quality control assay of Levocetirizine dihydrochloride, Phenylephrine hydrochloride and Paracetamol in...
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Posted by admin on Apr 30, 2019 in |
Different types of excipients were compared, in terms of their effect in (oral disintegrated tablets-ODTs) to optimize drug delivery and manufacturability. Therefore, the influence of excipients on the quality of ODTs was investigated by formulating and evaluate ODTs using an equal dose of water-soluble Baclofen (B) and poorly water-soluble Meloxicam (M) as model drugs. ODTs of both drugs were prepared using nine different co-process excipients for (B1-B9) and (M1-M9) formula (Pharmaburst®, Ludiflash®, F-melt®, Prosolv HD 90®, Prosolv SMCC 5O®, Prosolv ODT G2®, ProsolvEASYtab SP®, ProsolvEASYtab Nutra®, Lactose microfine), respectively by direct compression method. The prepared ODTs were evaluated for their: drug content, weight variation, thickness, disintegration time, wetting time, hardness, friability, and in-vitro dissolution. Both B-ODTs and M-ODTs showed no significant difference in the results of ODTs evaluation, by Using Design Expert 10 to select the best formulae of both drugs the best formulae were for poor water-soluble M9 (Lactose) > M3 (F-melt) > M6 (pro ODT) > M1 (Ph.brust) and for water-soluble: B4(Pro HD 90) > B3 (F-melt)...
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Posted by admin on Apr 30, 2019 in |
Oral extended release formulation with site-specific drug delivery formulations has been of greater importance in the field of drug delivery system to achieve adequate therapeutic results. The concept of novel gastro-retentive drug delivery system aroused due to site specificity behavior of the drug concerning drug absorption and solubility. The objective of the research work is to develop and evaluate gastro-retentive diltiazem hydrochloride modified pulisincap floating capsules. Diltiazem hydrochloride modified pulsincap floating capsules were formulated by filling the drug-polymer and diluents mixture in cross-linked hard gelatin capsules. Total of 15 formulations was developed and evaluated for pre capsule filling and post capsule filling parameters. Before development of formulation with different polymers, the cross-linked hard gelatin capsules were filled with only pure drug to carry out the diffusion studies of the drug through the cross-linked hard gelatin capsules among the developed, formulation containing carbopol 934p, i.e. F12 formulation was considered to be optimized based on its in-vitro drug release data and have shown the in-vitro drug release of 97.64 ± 3.45%...
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Posted by admin on Apr 30, 2019 in |
A simple, sensitive and specific RP-HPLC method was developed and validated for the determination of Orotic acid in bulk and capsule dosage form. Chromatography was carried out on an Enable C18G (250 × 4.6 mm i.d.,5µ) column using filtered and degassed mixture of acetonitrile and methanol in the ratio of 60:40% v/v as mobile phase at a flow rate of 1 ml/min and effluent was monitored at 280 nm. The method was linear over the concentration range of 10 – 70 µg/ml with a correlation coefficient of 0.999. The retention time of the drug was 9.1 min. The proposed method was validated by determining sensitivity, accuracy, precision, robustness studies. The developed method was effectively applied to capsules of orotic acid, and the % assay of the drug was found to be 99.65%. The method is simple, accurate, precise and reproducible and hence can be applied for routine quality control analysis of orotic acid in pure and capsule dosage...
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Posted by admin on Apr 30, 2019 in |
Malaria is a foremost universal public health problem, especially in the African region and development of resistance to the older and new generation malaria therapy, has become a persistent health threat requiring urgent solutions. This study intended to assess the ability of human subjects to accurately reconstitute antimalarial dry suspensions according to the manufacturer’s instructions. Two hundred (200) dry powders for suspension were procured and distributed to 200 human subjects, and the volumes reconstituted were noted. Results showed that only 24 subjects (12%) were able to reconstitute the suspensions as required by the manufacturer, while ninety-seven subjects (48.5%) made reconstitutions above the required volume and 79 subjects (39.5%) reconstituted below the required volume. Error in reconstitution was as high as 76%. This study emphasizes the need for health caregivers; especially nurses and pharmacists to make the required reconstitutions before dispensing the medication and also give adequate counsel to patients on the appropriate way to make reconstitutions to avoid untoward effects due to over or...
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