Posted by admin on May 31, 2019 in |
Bilayer tablet concept has been investigated to develop a combination of sustained and immediate release formulations. The present study aims to develop and evaluate to provide a combined therapy through a single tablet in which combinations of Metoprolol succinate and Hydrochlorothiazide were used. The pharmacokinetics advantage of this formulation was, drug release from the fast releasing layer leads to an immediate rise in the blood concentration. But the drug concentration in the blood is maintained at the steady-state level as the drug is released from the sustained release layer. The dose is varied upon the patient’s severity conditions. It varied from metoprolol succinate 25 mg to 200 mg and hydrochlorothiazide 12.5 mg to 25 mg. A bilayer dosage form is containing Metoprolol succinate SR and Hydrochlorothiazide IR, respectively for the management of...
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Posted by admin on May 31, 2019 in |
A simple and sensitive kinetic method is described for the determination of drugs viz., Bendamustine hydrochloride (BEN), Ciprofloxacin hydrochloride (CIP), Dorzolamide hydrochloride (DOR), Pantoprazole sodium (PAN), Warfarin sodium (WAR). This method is based upon a kinetic investigation of drug oxidation with alkaline potassium permanganate. Kinetics of the oxidation reaction is followed spectrophotometrically, as one of the reaction product, Mn (VI), absorbed at 610 nm. All variables affecting color development have been investigated and the conditions optimized. Among the methods applied were the Initial rate and fixed-time methods. Accounting for the applicability, the sensitivity, values of correlation coefficient (r) and intercept (a), the Fixed-time method is selected for these five drugs assay. The absorbance-concentration plots were rectilinear within the range of 8.5-51 µg.mL-1 for BEN 1-6 µg.mL-1 for CIP, 10-60 µg.mL-1 for DOR 20-120 µg.mL-1 an7-42 µg.mL-1 for WAR. The statistical data for the results challenged for the robustness of the fixed-time...
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Posted by admin on May 31, 2019 in |
The purpose of this research was to develop novel solid dispersions (SDs) of BCS class IV drug, canagliflozin hemihydrate (CFZ) using Eudragit® E PO (EE PO) as a carrier, to enhance its solubility and dissolution rate. Solvent evaporation technique was used to prepare SDs. The SDs were evaluated for saturated solubility, in-vitro dissolution study, solid-state characterization using FTIR, DSC, XRD and SEM, and flow properties. The solubility of CFZ in SDs increased manifold as compared with pure CFZ. Low values of angle of repose, Carr’s index, and Hausner ratio indicated good flow properties. The difference factor (f1) and similarity factor (f2) values suggested that dissolution profiles of the SDs were dissimilar to market product and the comparative dissolution curves revealed that SDs released CFZ faster than the marketed product. XRD patterns and DSC thermographs suggested that the SDs were present in an amorphous form, unlike pure crystalline CFZ. SEM studies showed CFZ has discrete crystalline particles whereas SD2 has diffuse, irregular asymmetrical structure. The SDs was superior to pure...
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Posted by admin on May 31, 2019 in |
2-Anilino-3-formylchromones are obtained in high yield by rearrangement of differently substituted C-(4-oxo-4H[1]-benzopyran-3-yl)-N-phenylnitrones. These compounds undergo various facile nucleophilic substitution reactions leading to the synthesis of various pharmacologically active chromone based novel heterocyclic systems like sulphonamides. The C-2 and C-3 are the main positions in the chromone moiety for the attack of nucleophiles and electrophiles, respectively. The chromone system behaves as Micheal acceptor. Generally, the nucleophilic attack at C-2 is accompanied by ring transformation. Protonation and alkylation occur on the oxygen of chromone moiety. In the present study, the substituted 3-Formylchromones were synthesized by Vilsmeyer haack Reaction. These substituted 3-Formylchromones were then reacted with phenyl hydroxyl amine in dry benzene to obtain substituted 2-Anilino-3-formylchromones which were further reacted with various substituted sulphonamides in dry alcohol to furnish final derivatives, i.e. chromone based sulphonamide derivatives (8a-h). Chemical structures of these synthesized derivatives were characterized by I.R Spectroscopy, 1H-NMR, 13C-NMR, and Mass spectroscopy analysis. Further, these obtained chromone based sulfonamide derivatives (8a-h) were evaluated in-vitro for their antibacterial and antifungal activities. Staphylococcus...
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Posted by admin on May 31, 2019 in |
Introduction: Appropriate understanding and adherence to antiretroviral regimens are important requisites to the presentation of good outcomes in the Prevention of Mother-to-Child Transmission (PMTCT) of HIV/AIDS. Objectives: This study aimed to evaluate the understanding and level of adherence to antiretroviral regimens among HIV-infected pregnant women. The factors that affect the level were also determined. Methods: Questionnaire was used to measure the knowledge while a modified Morisky Medication Adherence Scale (MMAS-8) and formula were used prospec-tively to determine their adherence level and the contributing factors. Data were analyzed using statistical products and services solution version 20. Chi-square test was conducted to determine the relationship between factors that affected knowledge and its level while logistic regression was used to determine the predictors of adherence. Results: A total of 394 women participated in the study, out of which 353 (89.6%) women had a good understanding of their PMTCT regimen, which was not affected by their educational levels. They had a low level of adherence among 301(76.4%) respondents. The adherence was not related...
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