Posted by admin on May 31, 2019 in |
Tinospora cordifolia (Willd) Miers (Synonym: T. sinensis (Lour.) Merr.) is a genetically diverse plant known for its immense medicinal properties due to the presence of bioactive compounds among which alkaloids are most vital. So, the present study aimed to estimate the total alkaloid content in wild and in-vitro regenerated plant & callus tissue of Tinospora cordifolia. Different solvents, i.e., methanol, ethyl acetate, water, diethyl ether, and chloroform, have been tried and compared for their extraction efficiency. The presences of alkaloids were tested via Wagner’s and Mayer’s reagents. The quantitative estimation had been made by UV/Vis spectrophotometer using a dye-Bromocresol green. The methanol extracts of wild plant’s stem showed the highest concentration (3.3%) followed by water (1.85%) and ethyl acetate (0.99%). The alkaloid content in chloroform and diethyl ether extracts of wild plant’s stem was 0.49% and 0.28% respectively. The in-vitro regenerated plant extracts also showed the presence of alkaloids (though in minute amount) in all solvents viz. methanol (0.95%), diethyl ether (0.060%), chloroform (0.012%), water (0.80%) and ethyl acetate...
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Posted by admin on May 31, 2019 in |
The evaluation of acute oral toxicity of chloroform extract of Tephrosia calophylla (CETC) and methanolic extract of Tephrosia calophylla (METC) and sub-acute toxicity of CETC was done on albino Wistar rats. The animals (female) were divided into four groups containing 3 animals in each group normal control, and 200, 400 and 800 mg/kg of freshly prepared extracts respectively, every 24 h orally for 28 days. At the end of each study, physical parameters and hematological analysis were evaluated. There was no significant difference (p>0.05) observed with control in terms of body weights, food and water intake, hematological parameters, and gross abnormalities. No mortality was recorded. Hence, the study was concluded as oral administration of CETC for 28 days does not cause toxicity. In conventional therapy, various studies have been done to identify antioxidants from the plant sources. Excessive production of free radicals causes direct damage to the biological molecules such as DNA, proteins, lipids, carbohydrates leading to progression and tumor development. Phytochemicals from the plant origin serve as natural...
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Posted by admin on May 31, 2019 in |
An innovative magnetically separable ThO2/Fe3O4 nanocomposite was successfully synthesized by hydrothermal method. The synthesized ThO2/Fe3O4 nanocomposite was characterized by UV-DRS, FT-IR, XRD, HR-TEM, BET, and TGA techniques. XRD and HR-TEM images displayed the overall spherical shape and confirmed the formation of well crystalline ThO2/Fe3O4 nanocomposite. The catalytic efficiency of ThO2/Fe3O4 was explored for the removal of malachite green dye (MG) from the aqueous phase. The degradation efficiency of about 99.53% was obtained, and the degradation reaction was maximal at pH 5. The results revealed that the synthesized ThO2/Fe3O4 nanocomposite showed enhanced photocatalytic activity compared to the ThO2 and Fe3O4 samples. Based on obtained results, the most plausible mechanism for removal MG has been proposed. The ThO2/Fe3O4 photocatalyst remained a robust performer even after five cycles. This nanocomposite is an effective visible light responsive material which can be used for the removal of various organic pollutants from the...
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Posted by admin on May 31, 2019 in |
Antioxidant and antihyperlipidemic activities of the extracts of Syzygium cerasoideum were investigated by studying their in-vivo effects on triton and cholesterol induced hyperlipidemia. Highest antioxidant activity was exhibited by methanolic extract followed by chloroform extract of S. cerasoideum. In triton induced hyperlipidemic model, the groups treated with the extracts of S. cerasoideum and pitavastatin demonstrated a significant decrease in the levels of TC, TG, LDL-C, VLDL-C particularly treatment with CESC at the dose of 200 mg/kg b.w resulted in significant decrease in levels of TC (67.60%), TG (47.89%), LDL-C (85.80%) and VLDL-C (47.89%) whereas HDL-C levels are significant to standard. In cholesterol induced hyperlipidemic model, the groups treated with the extracts of S. cerasoideum and pitavastatin demonstrated a significant decrease with the CESC and MESC at low doses in the serum levels TC (68.68%), TG (60.22%), LDL-C (85.44%), VLDL-C (70.71%) besides an increase in serum HDL-C (62.26%) levels when compared to cholesterol-induced hyperlipidemic control group. The treated groups of S. cerasoideum caused a significant decrease in the levels of...
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Posted by admin on May 31, 2019 in |
Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine disorders, affecting the patient’s psychological functioning and satisfaction with life. Settings and Design: Tertiary care hospital based case-control study was conducted. Material and Methods: the study was effectuated in 372 patients in total, including an equal number of cases and controls.PHQ-9 was used to determine the depression based DSM-IV directly diagnostic criteria for depression and PCOSQS was used to assess the quality of life. Statistical analysis used: Data was examined using descriptive statistics, spearman co-relation, Chi-square test, and odds ratios (OR) with 95% confidence intervals (95% CI). Results: The study shows an increased risk of depression in PCOS (76.96% of cases compared to 20.03% of controls), Odd’s ratio 5.95 (95% confidence interval [3.818 to 9.351]) and the depression was found to be having an impact on patient’s quality of life. Conclusions: The care of individuals with PCOS should include the screening and possible treatment for depression in order to achieve and sustain treatment goals considering the fact...
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