Posted by admin on May 31, 2019 in |
HAp and Zn-HAp Synthesis with several concentrations of Zn (5%, 10%, 15%, and 20%) w/w using Ca precursor from Maninjau Lake pensi shells was done with the sol-gel method. XRF for three hours obtained 96.525% Ca content in the form of CaO. XRD result for the synthesized samples showed the same diffraction pattern as the standard HAp (ICSD: 154493) phase which the intensity decreases with the addition of Zn concentration. In Zn-HAp 15% and 20% which were sintered at 600 °C for two hours, it was found that the impurity peaks were TCP [Ca3(PO4)2] and [Zn3(PO4)2] on the XRD pattern. In this study, the maximum concentration of Zn substitution in the HAp structure was obtained in Zn-HAp 10%. SEM result showed that Zn-HAp 10% had a better homogeneity than Zn-HAp 15% which produced impurities. Good antibacterial properties were also shown by Zn-HAp 10% for both tests of bacteria i.e. Staphylococcus aureus and Escherichia...
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Posted by admin on May 31, 2019 in |
In this study, 36 crystal structures available with type I-V inhibitors of VEGFR-2 kinase in the RCSB PDB were classified into DFG-in/-out conformation using visual analysis and KLIFS database. The focus was on Type II inhibitors as most kinase inhibitors belong to this category. Therefore, the crystal structures with DFG-out confirmation with a type II inhibitor were selected depending on the resolution and r-free value. 11 selected crystal structures were subjected to self-docking studies and interaction analysis, leading to the elimination of one crystal structure viz. PDB id 3U6J. 10 crystal structures were subjected to cross-docking analysis. No crystal structures were eliminated at this stage as 50% ligands were docked accurately at RMSD cut off ≤ 2Å. These structures were further evaluated for screening performance by calculation of five performance indicating terms. A rank order was established by performance terms. The next stage of selection was the calculation of enrichment factor and assessment of the number of chemical classes retrieved after docking of the DUD set along with actives....
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Posted by admin on May 31, 2019 in |
1,3-Indanedione derivatives, which are of wide interest because of their diverse biological and chemical applications. A series of novel 1,3-Indanedione derivatives are synthesized via KNOEVENAGEL condensing reaction mechanism by condensing 1,3-Indanedione with the 1-(4-aminophenyl) ethanone to form a styrylated indanedione leading to the formation of different Schiff base (imine) preparation by using different aldehydes with the appropriate solvent mix at a suitable temperature. All the synthetic derivatives were fully characterized by spectral analysis data (FT-IR, NMR, and Mass). The newly synthesized compounds are evaluated for their antimicrobial activity (by using Cup-Plate method against selected bacterial strains amongst S. aureus, E. coli among total compounds, compounds 7 was found to have higher activity against selected strains and the results were found to be as moderate activity, for anti-fungal activity-compounds 2,8 are more potent, compounds are evaluated for their antioxidant NO scavenging (compound 7 is having more activity), for DPPH scavenging (compound 8 is having more activity), and inhibition of lipid peroxidation (compounds 3 and 9 are having more activity), for...
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Posted by admin on May 31, 2019 in |
Objective: Oxidative stress and generation of free radicals leads to several chronic inflammatory diseases like arthritis, diabetes mellitus, cancer, etc. Arthritis is an immune-mediated systemic disorder known to impair the quality of life. In spite of development of drug discovery, therapeutic targeting of arthritis is still not satisfactory. Bellamya bengalensis has been long known for used in ailments like arthritis, asthma, conjunctivitis in traditional medicine. There are very few studies for clarification of scientific understanding of these therapies. In the present study, a purified fraction of Bellamya bengalensis mass (PBB) was assessed for oxidative stress in arthritis in Wistar rats. Methods: Arthritis was induced by 0.1 ml of Freund’s complete adjuvant (FCA) in the left hind paw of Wistar rats. After that, PBB was administered orally at 100 mg/kg, 200 mg/kg and 400 mg/kg doses for consecutive 28 days. A thorough investigation of serum and tissue parameters, including autopsied histopathological analysis, related to systemic dysfunction due to oxidative stress during arthritis were evaluated at the end of the study....
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Posted by admin on May 31, 2019 in |
The aim of the present study was to investigate antioxidant activity, total polyphenols and total flavonoids contents of extracts from two Moroccan Teucrium species (Teucrium polium and Teucrium aurum). The Antioxidant activity was evaluated in-vitro by three assays namely, free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP) and total antioxidant capacity. Total polyphenol content was measured using Folin-Ciocalteu assay. The aluminum chloride colorimetric test measured total flavonoids contents. The total phenols contents, flavonoids contents, and the antioxidant activity of T. polium extracts were higher than T. aurum. The phenols contents ranged from 109.28 to 20.61 mg GA E/ g dry extract. The total flavonoids varied between 102.99 and 10.33 mg RE/g dry weight. The extracts showed significant scavenging activity of DPPH, with IC50 values ranging between 0.40 and 2.12 mg/ml and a good ferric reducing power, with IC50 values varying from 0.15 to 4.23 mg/ml. The total antioxidant capacity assay showed that the water extract of T. polium had a highest activity with a value...
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