Posted by admin on May 31, 2019 in |
Two species of Riccia, namely Riccia billardieri and Riccia discolor, were studied to detect various amino acids qualitatively as well as quantitatively through HPLC. Seven amino acids (histidine, serine, tryptophan, asparagine, tyrosine, valine, and isoleucine) were observed to be common in both the species but varying significantly in their quantities. Riccia billardieri contained additionally four (lysine, glycine, cystine, and proline) amino acids and Riccia discolor one (glutamine) amino acid. The contents of histidine (0.597 mg g-1dw) and asparagine (0.323 mg g-1dw) were found higher in Riccia billardieri, but the concentrations of tryptophan (0.927 mg g-1dw), serine (0.169 mg g-1dw), tyrosine (0.024 mg g-1dw), valine (0.394 mg g-1dw) and isoleucine (1.770 mg g-1dw) were higher in Riccia discolor. The value of asparagine was almost similar in both the species. In Riccia billardieri the concentration of histidine (0.597 mg g-1dw) was observed maximum, whereas in Riccia discolor isoleucine (1.770 mg g-1dw) was found in the highest amount. The presence of amino acids indicates the potential use of Riccia in the pharmaceutical...
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Posted by admin on May 31, 2019 in |
Clopidogrel, a poorly water-soluble drug, has been the mainstay of platelet management in acute coronary syndrome (ACS) or percutaneous coronary intervention (PCI) for over a decade. Since Clopidogrel is a prodrug and requires hepatic metabolism for activation, it exhibits a slower onset of action upon oral administration. This time-lag before the onset on the action is highly undesirable for the treatment of critical conditions such as coronary intervention, which is a medical emergency during which the rapid onset of antiplatelet action is of paramount importance. To achieve rapid onset, intravenous is the preferred route of administration; however, due to poor aqueous solubility, development of the IV formulation of Clopidogrel presents a considerable challenge. In the present investigation, the liposomal formulation of Clopidogrel was developed, which enables IV administration and may potentially provide a rapid onset of action. The formulation was prepared and optimized using 32 full factorial designs with Design Expert 11 software and evaluated for critical quality attributes (% entrapment, particle size, PDI, zeta potential and Morphology, pH/dilution...
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Posted by admin on May 31, 2019 in |
Abelmoschus esculentus is one of the oldest urbane crops grown in many countries and widely distributed. Parts used of okra are fruit, leave seed, root wish showed to have numerous Medicinal significant uses. On the other hand, cigarette, smokers found to have a high a significant effect on liver kidney and other numerous organs in the body. Aim: The study aims to explore the possible protective effects of three parts of okra against nicotine-induced damage in many parts of the mice body. Methods: Fifty male Swiss albino mice were used throughout the study. After tow-weeks acclimatization period, the mice divided into 5 groups from the control group, nicotine-treated group, nicotine-okra pods extract -treated group, nicotine-okra skin extract treated group, and nicotine-okra seeds extract -treated group. Result: shown significant protective effects against nicotine damage effects as cholesterol level decrease in okra skin treatment with a significant difference in comparison with the positive group also okra protective effects on renal function have found that urea and creatinine levels decrease significantly in...
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Posted by admin on May 31, 2019 in |
Liquid electrodes of polymers imprinted with Isopropamide (ISP) were synthesized based on precipitation polymerization mechanism. The molecularly imprinted polymer (MIP) and non-imprinted polymers (NIP) were synthesized using (ISP) as a template. In the polymerization process, 2-Hydroxyethyl meth acrylate (2-HEMA) and 2-Vinyl pyridine (2-VP) were used as monomers. Di-vinylbanzene (DVB) was used as cross-linkers and benzoyl peroxide (BPO) as an initiator. The molecularly imprinted membranes and the molecularly non-imprinted membranes were synthesized using dibutyl sebacate (DBS) and nitrobenzene (NB) as plasticizers in PVC matrix. Slopes and detection limit of the liquid electrodes are ranged at (52.23-58.94) mV/decade and (1.2 × 10-6 – 2.0 × 10-5) M, respectively. Response time was 60 sec. Liquid electrodes were filled with 10-1 M standard solution of drug and observed stable response for a pH ranged from 1.5 to 12 and with good selectivity for over several species. The new synthesis electrodes were successfully used for the analyte estimated in preparation pharmaceutical sample without any time-consuming pre-treatment...
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Posted by admin on May 31, 2019 in |
Wild fruits play a significant role in human nutrition, especially as sources of carbohydrates, proteins, vitamins, minerals, dietary fibers, and enormous medicinal potential. Local people in different parts of the country have learned to live on many wild edible fruits available around their localities. Artocarpus hirsutus Lam. is an important wild edible fruit plant belongs to the family Moraceae and is commonly known as Wild Jackfruit, Ayani, Aanjili, etc. The present study was to trace out the variations in the profile of bioactive compounds from petroleum ether and chloroform extracts of Artocarpus hirsutus fresh fruit pulp using Gas chromatography-Mass spectrometry analysis (GC-MS). The identification of the bioactive components of the extracts was established by GC retention indices, by comparing their mass spectra with National Institute of Standards and Technology (NIST) data center. According to GC-MS spectral data, in petroleum ether extract five major compounds were identified. And in chloroform extract, seven major compounds were...
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