Posted by admin on Mar 31, 2019 in |
Artocarpus hirsutus Lam. is a common plant with a variety of folk medicinal value. The present study was conducted to evaluate the phytochemical and pharmacological properties of the ethanolic extract of Artocarpus hirsutus. The screening for various phytochemicals was conducted by using various standard procedures. Acute toxicity of the extract was determined by using OECD guidelines 423. The antidiabetic activity of the plant was evaluated by using the streptozotocin-induced diabetic model in Wistar albino rats. The histopathology of the pancreatic tissue was also performed. The antioxidant activity of the extract was also performed by using the liver homogenate of the animal. Statistical analysis was performed by using one way ANOVA followed by Dunnet’s test. The phytochemical screening of extract leads to the detection of various secondary metabolites like alkaloids, flavonoids, saponins, terpenoids, etc. No mortality was observed during acute toxicity studies up to the dose of 2000 mg/kg. The effect of the extract on parameters like body weight, fasting blood glucose level, SGOT, SGPT, ALP, bilirubin, total protein, urea,...
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Posted by admin on Mar 31, 2019 in |
The aim of this investigation was to design and optimize the Capecitabine niosomes derived from proniosomes using central composite design. Two independent variables viz., the molar ratio of drug to cholesterol (X1), surfactant loading (X2) and two dependent variables viz., the percentage drug entrapment (PDE) and mean volume diameter (MVD) were selected for the study. Proniosomes were prepared by a conventional slurry method and evaluated for the percentage drug entrapment (PDE) and mean volume diameter (MVD). The PDE dependent variables and the transformed values of independent variables were subjected to multiple regressions to establish a second order polynomial equation. Contour plots were constructed to elucidate the relationship between the independent and dependent variables further. From the computer optimization process and contour plots, predicted levels of independent variables X1, X2 (-0.77, -0.8 respectively), for an optimum response of PDE with constraints on MVD were determined. The polynomial equations and contour plots developed using central composite design allowed us to prepare niosomes derived from proniosomes with optimum...
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Posted by admin on Mar 31, 2019 in |
Gomphostemma Wall. ex Benth. belongs to the family Lamiaceae. The present study evaluated selected species of Gomphostemma endemic to the Western Ghats for their anti-inflammatory property. Traditionally, many species of Gomphostemma are used to treat malarial fever and inflammations caused by insect stings. Methanol extracts of Gomphostemma heyneanum var. heyneanum, G. heyneanum var. rottleri and G. eriocarpum were prepared and subjected to various in-vitro assays to examine their anti-inflammatory potential. Anti-inflammatory activity was initially screened with protein denaturation and proteinase inhibitory assays. Among the three extracts screened, G. heyneanum var. heyneanum showed significant activity comparable to the standard diclofenac sodium. Further, the effective extract of G. heyneanum var. heyneanum was evaluated for its effect on LPS induced RAW 264.7 cells. The effect of the extract on various inflammatory mediators like cyclooxygenase (COX), cellular nitrite and inducible nitric oxide synthase (iNOS) were analyzed. The extract inhibited cyclooxygenase and inducible nitric oxide synthase activity in a dose-dependent manner projecting the anti-inflammatory potential of the plant. The potent phytochemicals present in the...
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Posted by admin on Mar 31, 2019 in |
In the recent development, worldwide consumption of alcohol has shot up in the past decade as a part of lavish and Gen next lifestyle changes. There have been innumerable instances of people consuming alcoholic beverages and drugs at the same time. Hence in our study, Diclofenac and Metformin were selected as representatives of highly prescribed and overused drugs. Hence, the present study was planned to design dissolution media and to study drug release of different brands of the same drugs using newly designed media. Various hydroalcoholic media were prepared. Optimization of new, chemically defined dissolution medium was done by comparison of release profiles of Metformin HCl and from Diclo IR 1, Diclo DR 2 and Diclo SR1, Diclo SR2 tablets of Diclofenac Na. The Metformin IR and Diclofenac IR tablets showed faster release in strong beer than mild beer and rum. It can be concluded that both the strength and volume play an essential role in the release pattern of IR formulations. The SR formulations of Metformin HCl and...
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Posted by admin on Mar 31, 2019 in |
An accurate and precise High-Performance Reversed-Phase Liquid Chromatographic and UV spectrophotometric methods were developed and validated for the quantitative determination of Cilnidipine, a novel generation Ca channel blocker in the pharmaceutical dosage form. Good quality chromatographic separation of Cilnidipine was carried out by using thermo scientific model C18 Column (4.6 mm i.d. × 250 mm, 5 µm particle size) (based on 99.999% ultra-high purity silica) using mobile phase consisting acetonitrile: methanol (50:50% v/v) at flow rate of 1.0 mL/min. The λmax of the Cilnidipine in methanol (as a solvent) was found to be 242 nm. The drug following linearity in the concentration range of 2-10 µg/mL with a correlation coefficient value of 0.9999 for both UV and HPLC methods. The regression equation for Cilnidipine UV method was found to be Y = 0.081x + 0.0017 and for HPLC method was Y = 25517x – 4755. LOD and LOQ were found as 0.15095 µg/mL and 0.45742 µg/mL for UV method and for HPLC method it was found to be 0.003...
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