Posted by admin on Oct 31, 2024 in |
Cosmetics have been in high demand since ancient times until today. Lipsticks are a type of cosmetic used to enhance their appearance and protect the lips. Generally, waxes, oils, emollients, pigments, and varieties of dye or colouring agents are used to prepare lipsticks. Synthetic colours and other ingredients are hazardous to the human skin and body. Substituting synthetic ingredients with natural substances will decrease the side effects of lipsticks. Also, natural ingredients protect lips from cracking and drying out, etc. With this objective, a study was performed to formulate lipsticks using natural colour extracted from leaves of Amaranthus gangeticus L. It is a popular leafy vegetable in north-east India, and it possesses different pharmacological activities. The phytochemical screening of the extract showed the presence of alkaloids, glycosides, and tannins, which increase the nutritional value of the herb. A total of six formulations were prepared with different concentrations of colour extract and evaluated with parameters such as melting point, breaking point, spreadability, surface anomalies, stability, irritation test, etc. The formulations...
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Posted by admin on Oct 31, 2024 in |
Aim: The aim of the present study was to compare the efficacy of two different doses of labetalol for controlling these hemodynamic responses to laryngoscopy and tracheal intubation in controlled hypertensive patients. Material and Methods: Present study conducted on 90 patients posted for various elective surgeries under general anesthesia at our institute. Study populations were randomly divided into 3 groups. Group L1: Received Inj Labetalol 0.15 mg/kg iv 5 min before intubation, Group L2: Received Inj. Labetalol 0.3 mg/kg iv 5 min before intubation and Group C: Received 0.9% normal saline iv 5 min before intubation. Heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded prior to induction, at time of intubation and various intervals after intubation. Results: The control in HR, SBP, DBP, MAP and RPP was statistically significant between Group L1 and Group L2 at 3 min, 5 min post intubation. There was significant difference in HR throughout study time between L1 C and L2 C. Conclusion: Labetalol in both doses is...
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Posted by admin on Oct 31, 2024 in |
Recently, there has been increasing interest in donkey’s milk. Donkeys’ milk is a good alternative source for infant nutrition in the case of cow milk protein allergy and substitute to human milk. The main aim of this study was to evaluate and compare the proximate composition and physico-chemical properties of Andalusian breed donkey milk with different species mainly buffalo, cow and goat milk obtained from Kamareddy district of Telangana state. The milk samples were analyzed for proximate composition like fat, protein, carbohydrate, ash and total solids, physico-chemical properties such as pH, specific gravity, titratable acidity and viscosity. It was observed from the results that among all the species buffalo and goat milk showed higher levels of all the constituents than that of cow and donkey milk. The specific gravity, titratable acidity, ash, and protein content of buffalo milk showed higher than donkey milk, but had a lower lactose level than donkey, goat and cow milk. All the tested parameters were similar in buffalo and goat milk except lactose which...
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Posted by admin on Oct 31, 2024 in |
Purpose: The main purpose was to develop Oro-dispersible tablet to overcome the problem of dysphagia which is common in pediatric, geriatric and unconscious patients. Method: The Oro-dispersible tablets were prepared by direct compression method by using two different individual superdisintegrant like Sodium Starch Glycolate and Crospovidone as well as combination of superdisintegrant with newly marketed filler-binder Isomalt were used. Friability, disintegration time and percent drug release were taken as dependent variable. The excipients were used like Avicel as directly compressible excipient, Talc and Magnesium Stearate as lubricant, Sodium Saccharine and Mannitol as sweetening agent. The tablets were evaluated for hardness, friability, thickness, weight variation, wetting time, water absorption ratio, disintegration time and in-vitro drug release study. Venlafaxine hydrochloride, commonly used as anti-hypertensive and has anxiolytic property, poor bioavailability due to extensive first pass metabolism. Results: It was observed that hardness of all tablets was 3.13-4.11 Kg/cm2, friability of all formulation was found to be less than 1%, Weight variation was as per the USP specification and maximum % drug...
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Posted by admin on Sep 30, 2024 in |
Background: Peptic ulcer disease (PUD) is an injury of the duodenal mucous membrane that normally occurs due to an imbalance between the aggressive and the defensive factors. It accounts for an estimated lifetime prevalence of 5-10% globally. Aim: To evaluate the anti-ulcer effect and phytochemical constituents of extract and fractions of the leaves of D. guineense using an indomethacin-induced ulcer model. Methods: The powdered leaves were cold macerated in 95% v/v of methanol for 48 h. The extract was partitioned successively using ethyl acetate (EtOAc), and n-butanol to obtain their respective fractions. Phytochemical screening was conducted using validated methods. An acute toxicity study was carried out by modified Lorke’s method. The anti-ulcer study was conducted using an indomethacin-induced rat model. Results: The yield of the extract was 4.1% w/w while EtOAc and n-butanolfractions yielded 0.36 and 0.93% w/w respectively. There was presence of tannin, flavonoids, saponins and terpenoids in the methanol extract. Acute toxicity study indicated no mortality or any behavioural changes even at an oral dose of 5000...
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