Posted by admin on Jun 30, 2024 in |
This research investigates the anti-inflammatory potential of Azadirachta indica-loaded microsponges gel, presenting a novel therapeutic approach. The microsponges gel, formulated with Azadirachta indica, aim to enhance drug delivery efficiency for improved anti-inflammatory effects. The microsponges gel is formulated using Carbopol 934P (1% w/v) to optimized encapsulated microsponge. Prepared formulation was evaluated for pH, spreadability, viscosity, and ex-vivo drug deposition study. Characterization studies, in-vitro release assessments, and anti-inflammatory assays contribute to a comprehensive evaluation of the formulated microsponge gel. Preliminary results demonstrate successful formulation of Azadirachta indica-loaded microsponge gel. Characterization studies confirm the structure and composition. In-vitro release studies reveal sustained drug release, and initial anti-inflammatory assays indicate promising activity. This study underscores the potential of Azadirachta indica-loaded microsponge gel as a promising anti-inflammatory therapeutic strategy. The formulation’s sustained release profile and demonstrated efficacy in anti-inflammatory assays pave the way for further investigation and potential clinical...
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Posted by admin on Jun 30, 2024 in |
A simple, precise yet novel UV spectrophotometric method has been developed for the simultaneous estimation of luliconazole and eugenol. Two methods, namely the simultaneous equation method and the absorbance ratio method were tried for simultaneous analysis. Since the simultaneous equation method gave the best recovery; the simultaneous method was developed for the estimation of both drugs. The wavelength of interest is the wavelength maxima of both drugs; λmax of luliconazole 296 nm and λmax of eugenol 282 nm. The correlation coefficient value (r2) was found to be 0.99 for linearity studies both in methanol and phosphate buffer. Validation studies of the developed method were conducted as per ICH guidelines. The method was precise since the percent relative standard deviation was less than 2 and accurate since the percent recovery was between 99.42% and 105.16%. The developed method can be further used for simultaneous analysis of the drugs in bulk and formulation by UV spectroscopy. The development of a suitable analytical method for quantitative estimation is essential for assay and...
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Posted by admin on Jun 30, 2024 in |
Fungal infections represent a significant global challenge within the realm of dermatology. The prevalence of fungal infections is notably high, affecting approximately 40 million individuals in developing and underdeveloped countries. Considering this, our study proposes a novel approach: transdermal drug delivery utilizing herbal formulations to enhance efficacy & minimize side effects in the treatment of fungal infections. Seven Ayurveda plants extracts were selected & formulated in a 1:1 ratio. These herbal formulations were incorporated into dermal patches composed of HPMC& PEG. Subsequently, the herbal transdermal patch was subjected to characterization like UV spectrometry, folding endurance, thickness measurement, & surface pH determination. The antifungal property of these patches was evaluated against Candida albicans by determining MIC and Agar Well method. The prepared patches exhibited distinctive UV-visible spectra within the 200-800 nm range for the HPMC-based, displayed a thickness of 0.063 ± 0.01, a weight of 206 ± 5.1 mg, and a surface pH of 5.7. The transdermal drug delivery system demonstrated potent fungal inhibition at a concentration of 2.5 mg/ml,...
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Posted by admin on Jun 30, 2024 in |
Celiac disease is a multisystem immune based disorder that is triggered by the ingestion of gluten in genetically susceptible individuals. Our study was limited to a survey of the prevalence of Celiac disease in adult in two Syrian governorates (Homs and Tartous), Statistics were collected from hospitals and clinics of gastroenterologists and nutritionists, during the period of 2014-2022. 4000 cases of Celiac disease were recorded in these two Syrian governorates with a population of about 5 million people with ages ranging from 20-33, that is 0.08% in these cases. The presence of HLA class II antigens was observed in all people with Celiac disease as HLA DQ2 was found in 82% of celiac disease patients, and HLA DQ8 was found in the rest. It is very important that follow-up showed that the results of antibody tests (Transglutaminase IgA) in patients adhering to the gluten-free diet decreased from 200 to 100 “during a year of treatment” and to 20 “during two years of treatment” in all patients. The decrease in...
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Posted by admin on May 31, 2024 in |
The study was carried out to isolate and characterize pigment producing bacteria from rhizosphere soil. In our study, isolation and characterization of bacteria that produced pigments were performed using serial dilution, spread plating method followed by gram staining and various other biochemical tests (Oxidase, Catalase and IMViC tests). Our study concluded that bacteria isolated from rhizosphere soil are capable of producing pigment which is flexirubin (light orange in colour) and the bacterium belongs to the genus Chryseobacterium. After extracting the pigment, antimicrobial activity was performed, and it showed that the pigment has antimicrobial activity against both bacteria (E. coli and B. sphaericus) and fungi (Candida albicans). At 100µg/ml concentration, the pigment showed highest antioxidant activity with an absorbance of 0.116AU. The anti-inflammatory activity of the pigment was found to be highest at 1200µg/ml with an absorbance of 0.128AU. It is found that the pigment has the ability to increase SPF property of commercially available sunscreen by 0.713%. Thus different potentials of the pigment can be applicable in various industrial...
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