Posted by admin on Mar 31, 2019 in |
Neurodegeneration accounts for diseases like Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, etc. that come under neurodegenerative diseases. Parkinson’s disease is the second most common neurodegenerative disease. The main hallmarks of Parkinson’s disease are progressive loss of motor control and cognitive dysfunction. Current treatments are of reducing the symptoms, do not address the long term complications like motor and cognitive dysfunction and have serious side effects as well. Recent research has linked tyrosine kinase activity dysfunction and mitochondrial dysfunctions to the main etiologies of Parkinson’s disease of familial and sporadic origin. Since Parkinson’s disease occur due to multiple etiologies, using a combination of drugs that target different etiologies could be an ideal strategy to address neurodegeneration. In the present study, the neuroprotective efficacy of a combination of tyrosine kinase inhibitor; dasatinib and natural antioxidant resveratrol were studied. Stereotaxic infusion of rotenone was given to rats to induce Parkinson’s disease, with nine treatment groups. The neuroprotective efficacy of the drug combinations was evaluated in different treatment groups by checking, behavioral studies,...
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Posted by admin on Mar 31, 2019 in |
Objective: The objective of this research was a synthesis of silver nanoparticles from Murraya koenigii leaves in which the particles were characterized by various techniques and to evaluate the potential antibacterial activity of synthesized nanoparticles against various human pathogens. Methods: Murraya koenigii aqueous extract of leaves were prepared by the Soxhlet method, and the bioactive compounds were analyzed by phytochemical analysis. Silver nanoparticles were synthesized which are characterized by UV-visible spectroscopic analysis, XRD, TEM, FTIR analysis and antimicrobial activity was evaluated by agar well diffusion method. Results: Phytochemical analysis of Murraya koenigii aqueous extract of leaves showed the presence of alkaloids, phenols, flavonoids, terpenoids, coumarins, and steroids. The aqueous AgNo3 solution changed from green to dark brown color after incubation. UV-visible spectroscopic analysis showed the absorbance peak at around 420 nm which indicates the synthesis of Ag NPs. TEM image showed the formation of well-dispersed silver nanoparticles in the range of 5-25 nm. X-ray diffraction (XRD)-spectrum as evidenced by the peaks at 2θ values of such peaks 38.43°, 44.40°, and...
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Posted by admin on Mar 31, 2019 in |
Chalcone based structures have many interesting biological properties like anti-malarial, anticancer, antiviral, antibacterial, antifungal, anti-hyperglycaemic and photo-cytotoxicity activities. In this study, the novel chalcone derivatives (1a-1l) have been synthesized and investigated for antimicrobial activities. The MIC results of antimicrobial activities reveal that one of the chalcone derivative (2-Br- and 4-OCH3– group) against specific bacteria are quite significant. 3D QSAR, three dimensional quantitative structure activity is one of the most powerful technique which involves the quantitative relationship between the biological activity of a set of compounds and their three dimensional structural properties, using statistical correlation methods. Pharmacophore modelling and molecular docking play an important role in drug design. To elucidate the relationship between structures and its activity, field-based 3D QSAR analysis has been carried out of novel chalcone derivatives. Structural properties such as electrostatic, hydrophobic, aromatic, and hydrogen-bond donor and acceptor have been worked out for novel chalcone derivatives. To investigate the influence of drugstore, chalcone derivatives (1a-1l) have docked with receptor 2IOK and results displayed the highest Gscore of...
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Posted by admin on Mar 31, 2019 in |
Schizophrenia is a severe and disabling disorder which needs immediate administration of a suitable drug. Olanzapine, a BCS class II atypical antipsychotics drug of thienobenzodiazepine class is frequently prescribed to treat schizophrenia. The aim of the present investigation was to formulate mouth dissolving films of Olanzapine to improve its solubility and patient compliance. An inclusion complex of Olanzapine with 2-hydroxypropyl-β-cyclodextrin at a molar ratio of 1:1 enhanced solubility of the drug. A patient compliant MDF using Pullalan as a film-forming polymer was developed using the design of the experiment, 32 factorial design. The independent variables selected for optimization of MDF containing inclusion complex of 2-hydroxypropyl-β-cyclodextrin and Olanzapine were polymer concentration (3-5%) and plasticizer concentration (25-35%). The optimized film demonstrated optimum tensile strength of 3.91(gm/cm2), the disintegration time of 15.45 seconds and fast dissolution of 99.3% in 6 minutes. All the films formulated using solvent casting method were smooth and elegant in appearance. Rapid release of Olanzapine from MDFs indicated its suitability as an oral delivery system in the management...
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Posted by admin on Mar 31, 2019 in |
Indomethacin, an anti-inflammatory drug, exhibits poor water solubility and flow properties. Spherical agglomerates were prepared by crystallo-co agglomeration technique. Crystallization medium used for spherical agglomerates of Indomethacin consisted of acetone (good solvent); water (poor solvent); dichloromethane (bridging liquid). HPMC, PVP and PEG6000 this polymer were used in the agglomeration process. Spherical agglomerates were characterized by DSC, IR, XRD, and SEM. Micromeritic, dissolution behavior and compression studies were carried out. For optimization study Box Behnken Design used. Heckle plot studies showed low mean yield pressure and a low value indicating excellent compressibility and compatibility of agglomerates. Process variables such as an amount of bridging liquid, stirring speed and polymer ratio were optimized. The dissolution profile of the spherical agglomerates was compared with pure Indomethacin. Spherical agglomerates exhibited decreased crystallinity and improved micromeritic properties. The dissolution of the spherical agglomerates was improved compared with pure Indomethacin sample....
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