Posted by admin on Mar 31, 2019 in |
The objective of the present investigation was to develop a sustained release (SR) tablets of Doxazosin Mesylate by wet granulation technique using a combination of synthetic polymers (Eudragit RS-100 and Eudragit RL-100). Different batches of Doxazosin Mesylate sustained release tablets were prepared by using microcrystalline cellulose as diluents by wet granulation technique. The compatibility of the drug and excipients was ruled out by FT-IR studies and found to be compatible. Granules of prepared batches were evaluated for their physical properties and found to be good and satisfactory. Tablets were evaluated for various physicochemical parameters like hardness, thickness, friability, weight variation test, drug content, and in-vitro drug release. To study the effect of concentration of polymers on drug release from SR tablets, 32 full factorial design was applied. The concentration of Eudragit RS-100 and Eudragit RL-100 were used as independent variables, while percentage drug release at 2 h and 22 h were selected as the dependent variable. Contour as well as response surface plots were constructed to show the effect...
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Posted by admin on Mar 31, 2019 in |
The aim of this study was to (1) analyze the effect of fresh goat’s milk intervention on serum Carboxyterminal Cross-Linked Telopeptide of type I Collagen (CTX) and calcium in untrained healthy women, therefore goat milk can be used for osteoporosis therapy, (2) examined the relationship between levels of calcium and CTX after the intervention of fresh goat’s milk. The research design was a controlled randomized trial. Eighteen volunteers sedentary women were randomized into 2 equal groups (control, n=9, and trial, n=9), aged 18-19 years, healthy, and did not consume high calcium foods or drugs. The treatment group was treated with 250 ml/day of fresh goat’s milk, given in the morning, for 110 days. Fasting morning serum calcium and CTX levels were measured before and after fresh goat milk intervention. The data were analyzed by the statistical t-test and linear correlation with the significance level of 5%. Untreated, both serum calcium and CTX levels in the trial and control group were not significantly different (p>0.05). Treated, serum calcium levels were...
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Posted by admin on Mar 31, 2019 in |
The objective of the study is to make a pharmacokinetic evaluation of Pioglitazone floating tablets formulated employing HPMC K 15 M in comparison to Pioglitazone pure drug in rabbits. The two products were tested in a crossover RBD in healthy rabbits of either sex (n=6). The plasma concentrations of Pioglitazone were determined by a validated HPLC method. From the time versus plasma concentration data, various pharmacokinetic parameters (Cmax, Tmax, t1/2, AUC, Ka, and MRT) were calculated. Pioglitazone from the floating tablets formulated was absorbed slowly over longer periods in-vivo resulting in the maintenance of plasma concentrations within a narrow range over a longer period. The absorption rate constant (Ka) was decreased from 1.462 h-1 for Pioglitazone pure drug to 0.1598 h-1 with the floating tablets. MRT was increased from 9.82 h for Pioglitazone pure drug to 13.30 h with the floating tablets. There was no increase in the bioavailability of Pioglitazone from the floating tablets...
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Posted by admin on Mar 31, 2019 in |
The present study investigated the protective role of methanolic extract from Anethum graveolense L. (AGME) on bile duct ligation (BDL) produce hepatic fibrosis in the rat. BDL rats were divided into four groups, which received orally distilled water or AGME (200 and 400 mg/kg) for continuously 28 days. The BDL induced hepatic fibrosis by anti-fibrotic effect of AGME in the rats determined by serum level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBL), direct bilirubin (DBL), alkaline phosphatase (ALP), creatinine (CRT), glucose (GLU), triglycerides (TGL), cholesterol (CHOL), total protein (TP), albumin (ALB), transforming growth factor beta-1 (TGF-β1) and oxidative parameter like glutathione (GSH), malondialdehyde (MDA), total superoxide dismutase (SOD) and nitric oxide (NO) level. Biochemical estimation was complemented by histopathological measurement of the liver. Phytochemical in AGME were determined by qualitative and high-performance liquid chromatography (HPLC) analysis. All the serological level was elevated on treated with BDL group alone than in the sham control group (P<0.01). Treatment with AGME these elevations was mostly diminished. Also, increase in...
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Posted by admin on Mar 31, 2019 in |
The concept of fast dissolving drug delivery system emerged from the desire to provide patients with more convenient means of taking their medication. It is difficult for many patients to swallow tablets and hard gelatin capsules. The main objective of the study is to develop a reproducible formulation of fast dissolving tablets of Lornoxicam already used the therapeutic molecule to enhance effectiveness and to avoid side effects (gastric irritation) of the drug. Different batches of tablets were prepared by direct compression method using a different concentration of superdisintegrants like gum karaya, chitosan, and fenugreek seed mucilage powder. Before compression pre-formulation studies were done which includes characterization of the blend and physical compatibility studies with excipients. Effect of change in super disintegrant and their concentration on the formulation was studied. Final batches were compared for the superiority of superdisintegrants in the formulation of MDT of Lornoxicam. Tablets were evaluated for weight variation, thickness, hardness, friability, drug content, in-vitro disintegrating time and in-vitro drug...
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