Posted by admin on Apr 30, 2019 in |
The process and functioning of newly implemented periodic safety update report system (PSUR) in the hospital were assessed using validated PSUR function assessment questionnaire (PFAQ) vetted by Delphi panel. Classical Delphi survey method was used to assess and validate the PFAQ in two successive review rounds with Delphi panel. Final validated PFAQ was circulated among health care practitioners (HCPs) to rate their responses. Responses were recorded for 2 phases of 9 months intervals each and assessed. Success factors and performance indicators listed in the PFAQ were successively added or deleted by the Delphi panel, in two successive rounds of revisions, yielding the final draft of PFAQ. One hundred sixty (160) PFAQs were circulated among HCPs in different wards of hospitals out of which 94 (58.75%) filled forms were received by the end of phase 2 study period. We observed a significant improvement in the visibility and functioning of PSUR system in the responses collated from the HCPs during phase 2 of the study, compared to the phase 1 responses. Majority of responses...
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Posted by admin on Apr 30, 2019 in |
Push-pull osmotic pumps are controlled drug delivery systems for drugs with a broad range of solubilities; especially drugs that are poorly water-soluble. The aim of the present study was to evaluate the performance of the superdisintegrants (SD), crospovidone (CPVP), croscarmellose sodium (CS), and sodium starch glycolate (SSG), in push-pull tablets containing Nifedipine (NP) as a model drug. We performed an in-vitro dissolution test with phosphate buffer (0.05M) at pH 7.5 for 12 h. The amount of released NP was determined using a UV/Visible spectro-photometric method at a wavelength of 238 nm. At 12 h of release, the profile of CPVP- and CS-containing osmotic tablets was like that of the reference product Adalat OROS®, whereas the SSG-containing tablet showed differences. It is very important mention that in the first 6 h of the assay, all release profiles were different compared to the commercially available reference product. The tablets containing superdisintegrants showed faster drug delivery rates and a reduction in lag...
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Posted by admin on Apr 30, 2019 in |
Diabetes mellitus is possibly the world’s largest growing metabolic disease. Currently, a challenge is to identify such healthy foods that remain in the realms of obscurity and to establish them as functional foods to prevent the progression of metabolic complications. Glycine max is indigenous to India and is used extensively in the traditional system of medicine to treat diabetes, reduces coronary heart disease, lowers cholesterol level and other myriad ailments. Therefore, the objective of the study was undertaken to evaluate the effect of Glycine max leaves powder on type II diabetes mellitus subjects. The present study was conducted on type II diabetes mellitus subjects of the middle-income group which were selected from the main campus of Banasthali Vidyapith, Newai Rajasthan and divided into two groups, i.e., experimental (A) and control (B) groups (Age group: 40-60 years). Glycine max 10g leaves powder was incorporated in biscuits and administered to the experimental group daily for 60 days. Biochemical evaluations of blood sample of subjects were done. The present study indicates that...
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Posted by admin on Apr 30, 2019 in |
The modulatory effect of Opuntia elatior stem extract was studied in Swiss albino mice at dose 6 Gy of gamma radiation. Four groups were divided in the presence (experimental) or absence (control) of Opuntia extract 10 mg/kg body wt.) to observe hematological alterations. Four groups are Group I without any treatment as control, Group II treated with 10 mg/kg body weight dose of plant Opuntia elatior extract, Group III treated with Opuntia elatior extract (10 mg/kg body weight) and 6 Gy gamma irradiation dose, Group IV treated with 6 Gy gamma irradiation .These animals were scarified and their blood was collected by heart puncture from the syringe in the EDTA filled viles at days 1, 15 and 30 post-irradiations. There was no variation in RBC and WBC counts including hemoglobin content in the control group (without any treatment); but significantly decreased in 6 Gy gamma irradiation treated group IV, whereas a recovery pattern was recorded in experimental animals (Group II and Group III) and a normal value of hematological...
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Posted by admin on Apr 30, 2019 in |
Background and Objectives: Acute upper respiratory tract infections are the most frequent acute illnesses worldwide. This study has been undertaken for determining the diagnostic importance of Human Rhinovirus and other associated DNA/RNA viruses including human Respiratory Syncytial virus; Human Metapneumovirus; Human parainfluenza virus 1-4; human coronavirus; Human B, C, and E Adenovirus; and Human Bocavirus in common cold disease. Further, to detect the role of some immunological parameters including complement three and rhinovirus Ag (RhV-Ag) in rhinovirus infection. Patients and methods: The samples of 84 individuals infected with common cold were collected and studied. Viral nucleic acids either DNA or RNA were extracted and amplified using real-time multiplex PCR. Results: The most common type causative agent was hRv which accounted for 56.1% followed by hRv+hRSV-hMpv, 12.19% and hRv+hAdv-hBov, 9.75% respectively. Also, the most rarely infection was hRSV-hMpv which found only in one case. On the other hand, complement three was used as a potent immuno-parameter to detect the level in a sample of 80 tested individuals infected with human...
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