Posted by admin on Apr 30, 2019 in |
Introduction: Mental disorders account for nearly 12% of the global burden of disease. They are expected to become the second most important cause of disability in the near future. Medical students remain under great academic pressure to pass internal and external exams which continuously keep them under pressure. It is also very important to know how students feel rather than to treat only those who visit clinicians. Undiagnosed mental disorders adversely affect physical wellbeing too. Objectives: The primary objective of this study was to evaluate the subjective presence of mental health disorder in undergraduate medical student. Materials and Methods: DSM -5 self-rated symptom measure tool was used to detect the presence of mental health domains. Presence of any symptom in level 1 was further assessed by measuring its severity in level 2. Results: Study detected 86% of students had felt disturbed mental health in the past two weeks. Males had a higher number of symptoms than females. Manic symptoms were most common followed by anxiety and depression. Mania and...
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Posted by admin on Apr 30, 2019 in |
Picrorhiza kurroa Royle ex Benth, belongs to the family Scrophulariaceae has gained immense medicinal value in Ayurvedic as well as in modern medicines including antioxidant, anti-inflammatory, anti-pyretic, immunomodulatory, anticancer, hepato-protective, etc. The present study aimed to ascertain analgesic and antipyretic activities of rhizome extracts of Picrorhiza kurrooa in Wister rats. Methanolic extracts at 260 mg/kg as well as 520 mg/kg exhibited highly significant (P<0.01) analgesic and antipyretic activity by oral dose for analgesic and rectal dose for antipyretic effects. Whereas hydroalcoholic extract showed significant effects at 520 mg/kg but not as good as that of methanolic...
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Posted by admin on Apr 30, 2019 in |
Medicinal herbs are a precious heritage for us and since long is a part of traditional as well modern system of medicine. These herbs provide less toxic and more effective drug molecules which are helpful in various ailments. In the present work, we have focused on an edible herb which bears a large number of medicinal properties. Fagopyrum esceulentum Moench (Buckwheat) has a long tradition of being used as food and medicine which is endorsed with abundant of nutrients like flavonoids, polyphenols, proteins, vitamins, phytosterols, carotenoids, and minerals, etc. in it. In the present study, chemical and pharmacological investigation of buckwheat seed ethanol extract were carried out for determining its usefulness in human health. The GC-MS analysis was performed and based on Mass Spectra fragmentation pattern and retention indices, phytoconstituents were identified. Major constituents identified were 9-octadecenamide, n-hexadecanoic acid, ethyl linolate, 9-octadecenoic acid (z), 2, 3-dihydroxypropyl ester, ergost-5-en-3-ol (3.beta.24r), gamma-sitosterol, lupeol, fumaric acid. These phytoconstituents show various pharmacological activities like anti-inflammatory, antioxidant, antibacterial, anticancer, anti-hyperglycemic, dyslipidemic and cardiovascular...
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Posted by admin on Apr 30, 2019 in |
An accurate, precise, sensitive and selective stability indicating High-Performance Thin Layer Chromatographic method has been developed and validated for simultaneous estimation of Amlodipine besylate (AML) and Losartan potassium (LOS) in bulk and pharmaceutical dosage formulation. Chromatographic separation of both the drugs was achieved by using TLC aluminum plates pre-coated with silica gel 60 F254 as the stationary phase and chloroform: methanol: toluene: acetic acid (5.5: 2.5: 2: 0.05 v/v/v/v) as mobile phase. Densitometric analysis was carried out in the absorbance mode at 237 nm. The Rf values found to be 0.23 ± 0.02 and 0.74 ± 0.02 for AML and LOS respectively. The method was validated in compliance with ICH Guideline for linearity, the limit of detection (LOD), the limit of quantification (LOQ), precision, specificity, accuracy, repeatability, and robustness. Linear regression analysis data for the calibration plots showed good linear relationship over the concentration range of 100-400 ng/spot (r2 = 0.9993) and 500-1750 ng/spot (r2 = 0.9991) for AML and LOS respectively. The LOD and LOQ were 24.46 and...
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Posted by admin on Apr 30, 2019 in |
The main objective of this study is to compare the reduction rate of surgical site infection (SSI) between Triclosan coated (TC) and conventional surgical (CS) suture postoperatively. Surgical site infection (SSI) can be presented as a major challenge for people in the sense of mortality and morbidity mostly in developing countries. The result of SSI with antibacterial suture in developed countries have been already reported; however, these interventions have been studied very little in those developing and underdeveloped countries where lifestyle and the hospital facility plays a major role in infection. A single-center randomized controlled trial was conducted at Civil Hospital Aizawl, Mizoram, India. A total of 110 patients were recruited for the study with a 1:1 ratio in both TC and CS. Superficial SSI was assessed as primary outcomes according to the Centre for Disease Control (CDC) guidelines until 30 days. Secondary outcomes also measured for 1st and 3rd days of surgery. Sutures were tested in laboratory condition for their antibacterial activity before use in surgery. Zone of...
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