Posted by admin on Mar 31, 2019 in |
Recent advances in novel drug delivery aims to enhance the safety and efficacy of drug molecule by formulating a convenient dosage form for ease of administration and to achieve better patient compliance. One such approach is oral disintegrating tablets. Oro-dispersible tablets are a suitable means of drug delivery system for better patient compliance, rapid onset of action, increased bioavailability. The purpose of the present research was to formulate and evaluate the mouth disintegrating tablets of metoclopramide hydrochloride. Metoclopramide hydrochloride was used as the active drug, and superdisintegrants like sodium starch glycolate (SSG), crospovidone (CP) and croscarmellose sodium (CCS) were used in the formulation. A total of 7 formulations were fabricated using a direct compression method. The amount of superdisintegrants was varied in each formulation. All the formulations were subjected to pre and post compression parameters. Preformualtion stability study was done to ensure the drug-excipient compatibility study. The effect of superdisintegrants on wetting time, disintegration time and dissolution profile were evaluated. Among the formulated batches, the formulation containing CP 5%...
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Posted by admin on Mar 31, 2019 in |
Background: Major orthopedic surgeries are divided into 3 major surgeries: total or partial hip replacement (TPHR), total knee replacement (TKR), and hip fracture surgeries (HFS), these surgeries are considered as high-risk surgeries for the development of venous thromboembolism (VTE) which includes deep vein thrombosis (DVT) and pulmonary embolism (PE). In general there are several factors that increase the VTE risk post these surgeries, this study was carried out to figure out the effect of the following factors on the VTE rate post these surgeries: age, gender, type of anesthesia, admission days before surgery, duration of hospital stay, duration of surgery, co-morbidities, the presence of any other VTE risk factors and the type of orthopedic surgery, at Jordan University Hospital (JUH). Methods: This was a prospective observational study; it was carried out at JUH. One hundred and seventy patients were enrolled in the study. A follow-up period up to 35 days was used starting from the surgery date. As extended VTE prophylaxis, 31.8% (54/170) of patients have prescribed Enoxaparin 40...
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Posted by admin on Mar 31, 2019 in |
The present manuscript describes a new simple, specific, precise and accurate RP-HPLC development and subsequent validation for simultaneous estimation of Pyrantel pamoate and Febantel in their combined dosage form. The proposed method involves the utilization of a hypersil BDS C18 (150 × 4.6 mm, 5 µ) column, mobile phase containing acetonitrile: phosphate buffer in the ratio 85:15% v/v and 55:45% v/v with apparent pH adjusted and maintained to 3.5 using 0.01M orthophosphoric acid, pumped at a flow rate of 1.0 ml/min. The injection volume was 20 µl, and detection was monitored at 286 nm. The components were eluted by gradient mode. The peaks obtained were sharp and well resolved with retention times 4.5 min (Pyrantel pamoate) and 6.5 min (Febantel). The calibration curves were linear (r2=0.999) over the concentration range of 25-150 µg/mL for Pyrantel pamoate and Febantel both. Validations of the proposed method were carried out for its accuracy, precision, linearity, robustness LOD and LOQ according to ICH Q2 R1 guidelines. The statistical analysis was carried out and...
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Posted by admin on Mar 31, 2019 in |
Background: Studies on challenges of the visually impaired population during medicine utilization, their difficulties and the Pharmacist’s information assessment towards such population are very limited. Objective: To study the problems during medicine utilization among blind patients in Nepal. Methods: A cross-sectional descriptive study was carried out in 120 blind persons using a schedule at various blind associations, hostels, colleges, and a blind cricket tournament. Participants of at least 18 years and had taken 2 medicines were included in the study. SPSS was used for analysis. Results: We found 60% could read Braille alphabet with most were male (63.88%) population. We found 21.43% only had adherence in their medicines. Most people had faced problem while using liquid dosage form where 46.7% of people spilled drug during administration and even 12.5% administered the drug directly from the bottle. The information given by dispenser was found to be inadequate. We found 65.8% of participants didn’t get to know their medicine name, staggering 80% haven’t got their medicine expiry date, 60% haven’t known...
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Posted by admin on Mar 31, 2019 in |
Formulating the essential oils with the chemotherapeutic agents in nanocarrier may develop a potent effect on the cancer cells. A nanoemulsion consisting of the camphor oil (CAM-NE) and Ifosfamide (IFO)-loaded in CAM-NE (CAM-IFO) were physically characterized by the zetasizer and evaluated for in-vitro antiproliferative activity against MCF-7 breast and HeLa cervical cancer cell lines. The cell growth inhibition, cell morphological changes, and apoptosis of the cancer cells, subjected into the CAM-NE, CAM-IFO and the free-drug (IFO), were examined by the MTT assay, light microscopy, and DAPI stain, respectively. It has been found that the dispersed nanodroplets of CAM-NE had mean particle diameter and zeta potential of 34.975 ± 9.35 nm and -13.75 ± 1.06 mV, respectively, which had got enlarged to 96.235 ± 9.00 nm and -22.00 ± 0.49 mV, respectively, when IFO was incorporated (CAM-IFO). The results of the cell growth inhibition and cellular uptake have demonstrated that CAM-IFO has the highest cytotoxic effect on both tested cells when compared with CAM-NE and IFO. These findings suggest that...
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