Posted by admin on Feb 28, 2019 in |
Background: Chronic periodontitis (ChP) is the most common form of periodontal diseases. The progression rate may be influenced by local, systemic conditions and environmental factors that can alter the normal host response to bacterial plaque and affect the susceptibility to disease. Several studies have reported a role for vitamin D receptor (VDR) gene polymorphisms in numerous immunological activities. The present study purpose was to investigate whether FokI polymorphisms in the VDR gene were associated with the incidence of ChP in a Syrian population. Methods: The study sample comprised eighty Syrian subjects who were allocated into two groups. 50 patients were included in the group (ChP), whereas 30 matched individuals with no periodontal disease were included in the group (R). DNA was isolated from peripheral blood cells. Subsequently, genotyping of the (VDR) polymorphism was performed by a polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis using FokI enzyme. Statistical analysis was carried out to assess the differences between study groups. Results: Alleles T and C were present at...
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Posted by admin on Feb 28, 2019 in |
Diabetes is a group of metabolic disorders characterized by a chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both. The chronic hyperglycemia in diabetes is associated with long term damage, dysfunction, failure of kidney, nerves and blood vessel. Nowadays, herbal treatments available for diabetics are eroding the share of allopathic formulations. Currently, the spray drying technique has been widely used for improving processability, biopharmaceutical performance as well as modifying the physical form of various phyto-extracts. Extract of mulberry being sticky may find difficulty in its formulation to tablet dosage form. Across the world, mulberry has been used for its medicinal importance. Looking at its availability and medicinal prospects spray dried mulberry extract was prepared and which is finally assembled into a tablet dosage form. Inert excipients are used to deal with processability, amorphous form and bioavailability issues. Spray drying of the mulberry extract was carried out by using carrier maltodextrin. Results obtained shows excellent/good flowability, compressibility, and compatibility. The dissolution profile of spray dried extract...
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Posted by admin on Feb 28, 2019 in |
This study reports the potential of a marine mollusk, Chicoreus sp., as a producer of peroxisome proliferator activated receptor-gamma (PPAR-γ) ligand that activate the scavenger receptor class B type 1 (SR-B1) for anti-atherosclerotic activity. The objective of this study is to determine the cytotoxicity of the obtained compound C35, with a molecular weight of 270.1 and the level of SR-B1 expression of a hepatocellular carcinoma cell line (HepG2) after treatment with the compound. Various concentrations of compound C35 were treated against HepG2 to determine its cytotoxicity level (MTS assay) and against transfected HepG2 with SR-B1 promoter (luciferase assay). A non-toxic result obtained in MTS assay where the IC50 is exceeding 100 µg/mL. For luciferase activities, the compound increases the transcriptional regulations of SR-B1 promoter at specific effective concentrations of 12.5 µg/ml with 1.8-fold higher as compared to the positive control. The compound increased the transcriptional regulations of SR-B1 promoter activity and subsequently increased the luciferase activity of the assay system which also reflects the ability of it as a...
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Posted by admin on Feb 28, 2019 in |
A series of novel Imidazo[1,2-a]pyridine derivatives were synthesized in satisfactory yield by microwave assisted synthetic method. The structures of the newly synthesized compounds are characterized by 1H-nuclear magnetic resonance (NMR), Fourier transformed infrared (FTIR), mass spectral analysis (LC-MS) and screened for their in-vitro anti-inflammatory activity. Among the synthesized compounds N-(3,5-bis(trifluoromethyl)benzyl)-4-((2-(6-methyl-2-(p-tolyl)imidazo [1,2-a] pyridine-3-yl) acetamido) methyl) benzamide and N- (4-methoxybenzyl)-4- ((2-(6-methyl-2-(p-tolyl) imidazo [1,2-a]pyridin-3-yl) acetamido) methyl) benzamide are possessing high anti-inflammatory activity against standard drug Aspirin. A majority of the tested compounds had shown good consequence to moderate anti-inflammatory...
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Posted by admin on Feb 28, 2019 in |
The present study involves the formulation and in-vitro characterization of sustained release matrix tablets of Ambroxol hydrochloride, a potent mucolytic agent used in the treatment of respiratory disorders. FTIR analysis confirmed the absence of drug-polymer interactions. Sustained release matrix tablets containing 75 mg were formulated employing HPMCK15 and xanthan gum as release retarding polymer and dicalcium phosphate and microcrystalline cellulose as diluents. The powder blend was evaluated for micromeritic properties. The matrix tablets were prepared by direct compression technique. The prepared tablets were evaluated for uniformity of weight, hardness, friability, and uniformity of content. All the formulations showed compliance with pharmacopoeial standards. The in-vitro drug release studies were carried out for a period of 12 h using USP type II dissolution apparatus at 50 rpm by taking 900 ml of 0.1 N HCl (pH 1.2) as dissolution medium for first 2 h and later replacing it with 900 ml pH 6.8 phosphate buffer solution for a period of 10 h at 37 ± 0.5 °C. Among the different combinations...
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