Posted by admin on Jan 31, 2019 in |
Introduction: Antibiotics suppress the growth of or kill another microorganism at very low concentrations. Therefore this is the one of the supreme invention need of this era. Most bacteria are becoming resistant to various antibiotics, make a limitation for treating minor and major infectious. Hence, determining the resistance patterns in the geographical area will help in choosing and use of the effectiveness of antibiotics. Methods: It is a prospective observational study carried out in 167 patients in an inpatient Department of Surgery and Medicine between October 2017- April 2018. The enrolled patient data was collected in data collection form and subjected to descriptive statistics. Results: Among 167 observed cases 71.8% was male, and 28.2% was female. The majority of the patient was at the age group of 61-70 years (28.1%). E. coli 27.5% is the most commonly found organism followed by Klebsiella species 16%, E. coli with ESBL producer 8%. Amoxiclav 44.3% was found as the most resistant antibiotic followed by Ampicillin 43.1%, Cefotaxime 37.7%, Ceftazidime 31.1%, Ciprofloxacin 31.1%,...
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Posted by admin on Jan 31, 2019 in |
The main objective of the present investigation was to formulate and evaluate fast dissolving tablets of Roflumilast solid dispersions using a direct compression method. Roflumilast solid dispersions were prepared by solvent evaporation as well as melting method. Roflumilast is a selective, long-acting inhibitor of the enzyme PDE-4 and has anti-inflammatory effects. It is used orally in the treatment of chronic obstructive pulmonary disease (COPD). The roflumilast drug belongs to BCS class II drugs that have low solubility and high permeability. The current research work was focused on improving the aqueous solubility of Roflumilast using solid dispersion technique and enhancing the dissolution rate. Based on the results of solubility analysis, phosphate buffer pH 6.8 was chosen as the dissolution medium. The powder blend of Roflumilast solid dispersions was evaluated for flow characteristics. The fast dissolving tablets of Roflumilast solid dispersions were subjected to post-compression parameters such as weight variation, hardness, thickness, friability, drug content, wetting time, water absorption ratio, in-vitro dispersion time and in-vitro disintegration time and the results were...
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Posted by admin on Jan 31, 2019 in |
Madhuca longifolia var. latifolia belonging to the family Sapotaceae which was also known as Mahua and Butter tree. The present study was designed to identify the fatty acids present in oil and to analyze the elements present within the seed and seed cake. After extraction of oil, it was found that the seeds were high in oil content within the kernel. The oil percentage found in seed was highest recorded as 57.59%. In GCMS analysis of oil, the oleic acid which is monounsaturated fatty acid (45.11%) was recorded highest in amount compared to others. Elements within the seed and seed cake were analyzed using Energy Dispersive X-ray Spectroscopy. Concentrations of seven elements such as Calcium (35.53%), Carbon (33.56%), Oxygen (22.46%), Nitrogen (5.20%), Phosphorus (2.18%), Magnesium (0.23%) and Sodium (0.04%) had been determined in seed cake by Energy Dispersive X-ray Spectroscopy. The present study provides information about the availability of some essential minerals and fatty acids, which can be used as nutraceuticals and it may also help in developing the...
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Posted by admin on Jan 31, 2019 in |
Introduction: While many medical students have a special talent in psychiatry, attracting them to this specialty is a problem. The purpose of this study was to examine the impact of psychiatric education on the attitude of medical students on psychiatric patients. Method: In this observational study, 200 medical externs and interns were recruited. Before and after attending the 4-week psychiatry education course, the subjects were asked to express their attitude, knowledge, and experiences concerning psychiatry by completing the attitudes toward psychiatry (ATP-30) and the 6-item psychiatric experience, attitudes, and knowledge (PEAK-6) scales. Twenty-six subjects didn’t meet inclusion criteria or answered incompletely to the questionnaires Data were analyzed by t-test and paired t-test. All statistical assays were performed with SPSS19. Results: The average age of participants was 24.86 ± 1.85 years. Of the 174 students who were finally evaluated, 84 were externs (25 male, 59 female) and 90 were interns (35 male, 55 female). A significant statistical difference was found between the mean scores of PEAK-6 among the students before...
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Posted by admin on Jan 31, 2019 in |
Duck egg yolks contained fat and higher cholesterol than chicken eggs. A high-fat diet has caused obesity to impact for the development of diseases such as type II diabetes, stroke, atherosclerosis, hypertension, cardiovascular disease and certain forms of cancer. The purpose of using laboratory animals determined the effects of duck egg yolk to body weight, lipids profile, and atherosclerosis diseases. The study design is randomized post-test only control group design with Wistar rats. Twenty-seven rats were divided into three groups (nine rats per group): control, group I and II. The control group was given standard diet, and other groups received their respective agents (pellet duck egg yolk and raw duck egg yolk). After rats were treated for 30 days, blood samples were taken for examination of blood plasma lipids profile. These results have indicated that an increase in body weight of rats in both treatment as well as increase total cholesterol, LDL cholesterol, triglycerides, ratio of total cholesterol to HDL cholesterol, atherogenic index (AI), VLDL, and decreased in blood...
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