Posted by admin on Feb 28, 2019 in |
Spilanthes acmella (SA) commonly known as “Akarkara” frequently available in most of the areas of India, Sri Lanka, Bangladesh, China, Japan, and Thailand; is well reputed in the indigenous system of medicine for its medicinal use in toothache and rheumatic fever. The present study was aimed to evaluate its traditional use in liver diseases using the in-vivo model of rabbits. The Spilanthes acmella extract (SAE) based gel was investigated for its hepatocurative activities in Paracetamol intoxicated (2 g/kg) rabbits. Rabbits were divided into three groups, normal control (saline-treated) hepatotoxic control (Paracetamol treated) and remaining one was hepatotoxic treated with the SAE -based gel (400 mg/kg) for 7-14 days. One serving as control another as hepatotoxic and last one as treated with Paracetamol and then SAE-based gel Group 2nd and 3rd were intoxicated with Paracetamol. After the 3rd day of the treatment with Paracetamol, increased serum transaminases (sGOT and sGPT) and alkaline phosphatase (ALP) levels were observed. In the case of hepatocuration of SAE -based gel caused a significant reduction...
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Posted by admin on Feb 28, 2019 in |
In recent years metallic nanoparticles, represent one of the most comprehensively studied materials because of their application in biology The synthesis of silver nanoparticles using biological entities has received immense attention in the area of research. Medicinal plants have attracted interest over antibiotics due to a rapid increase in the rate of infections, development of antibiotic resistance in microorganisms and side effects of antibiotics. In the present study biosynthesis of silver nanoparticles was performed using Syzygium cumini. Spectrochemical studies indicate the surface plasmon resonance band and the presence of a capping agent responsible for the synthesis of AgNPs. The results revealed that S. cumini along with synthesized AgNP found to possess microbicidal effect. 400 µl of synthesized AgNP was found to be resistant against Bacillus sp. (23 mm), followed by S. epidermis and A. niger (22.5 mm). HPLC chromatogram reveals the presence of flavonoids such as quercetin and myricetin responsible for...
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Posted by admin on Feb 28, 2019 in |
The present investigation reports the fungal Aflatoxins contamination in groundnut samples collected in different locations in the Rayalaseema area, Andhra Pradesh, India. Aflatoxins were extracted by liquid-liquid extraction method using chloroform solvent. The qualitative and quantitative analysis of aflatoxins present in the samples was done using TLC and HPLC techniques. Among the eight samples in the study two samples S3 and S6 were less infected with aflatoxin-producing fungi, and hence aflatoxins were detected in HPLC study. Samples S1 and S4 consist of only B2 and G2 aflatoxins respectively. The chromatogram obtained for sample S2 shows two peaks representing G2, B2 aflatoxins with 0.84 ng/g, 13.0 ng/g quantity. Sample S5 was also found to have two peaks representing G2, B2 aflatoxins with 10.9 ng/g, 0.55 ng/g quantity respectively. Sample S8 chromatogram consists of two peaks represents aflatoxin G1 and G2 with 0.89 ng/g, 13.3 ng/g quantity respectively. Among the samples in the study, a high number of aflatoxins was identified in sample S7. In S7 sample aflatoxin G1, G2 and...
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Posted by admin on Feb 28, 2019 in |
Purpose: To study the prescribing pattern of AEDs for a different type of seizures in the pediatric population and disease conditions other than epilepsy and to identify the drug interactions with the use of AEDs among the study population. Methods: This six months long prospective observational study was conducted at in-patient wards of JSS Hospital. The case sheets of all in-patients were reviewed daily and enrolled the patient’s who met the study criteria. Enrolled children were followed until discharge to identify the usage pattern of AEDs and other drug therapy and any drug interactions involved in the use of AEDs. Results: Total number of the study population was 294, and the mean age of the study population was 8.64 ± 3.7 years, and the majority of the then were infants [1 month – 1 year (35.03%)], followed by toddlers [1-2 years (32.6%)]. In our study, the majority of children were on monotherapy (64.96%) followed by dual therapy (26.53%). Clobazam was the highly prescribed drug as monotherapy (39.79%), and fosphenytoin...
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Posted by admin on Jan 31, 2019 in |
Paracetamol is a well-known drug for its antipyretic, analgesic and anti-inflammatory activity. The drug being an OTC had been used more frequently than required. As a result of this overdosage of the drug caused a hepatotoxic effect. So to overcome this, an approach of PEGylation was chosen. PEG 1500-Paracetamol, PEG 6000-Paracetamol, PEG 1500-Glycine-Paracetamol, and PEG 6000-Glycine- Paracetamol. The Prodrugs synthesized were subjected to in- vitro dissolution at λmax 256nm at pH 1.2, 4.5 and 6.8. The studies revealed that % drug release was more at pH 6.8 rather than at pH 1.2 and 4.5, for PEG 6000-Gly-Paracetamol than PEG 1500-Gly-Paracetamol and also PEG 6000-Paracetamol % drug release was more than PEG 1500-Paracetamol. In-vivo Analgesic activity by Tail Immersion method revealed that PEG 6000-Gly-Paracetamol and PEG 1500-Gly-Paracetamol has higher analgesic activity than PEG-PEG 6000-Paracetamol and PEG 1500-Paracetamol, which indicates the influence of spacer, i.e., Glycine on drug release. In-vivo Analgesic activity by hot plate method and acetic acid methods revealed that PEG 6000-Gly-Paracetamol and PEG 6000-Paracetamol has higher analgesic activity...
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