Posted by admin on Dec 31, 2018 in |
Objective: To evaluate and compare pH and titrable acidity (TA) of various commonly consumed commercially available soft drinks. To evaluate and compare the weight of enamel dissolution and surface micro-hardness of the tooth after exposure to commonly consumed commercially available soft drinks. Methods: 60 human enamel specimens were randomly divided into 5 groups: Group 1: Kinley water (control), Group 2: Pepsi cola, Group 3: Urzza the liquid charger, Group 4: Tropicana orange delight, Group 5: Patanjali amla amrit. For the five solutions pH and TA was calculated. Each of the specimens were then pre-weighed and exposed to the soft drink for 14 days and weighed again. The mean weight difference was calculated for all of the samples. The same samples were subjected to the micro-hardness test (Vickers hardness number). Results: The pH of all the test drinks ranged from 2.55 to 3.74, which is far below critical pH. The pH and TA of carbonated drinks were statistically significantly lower than non-carbonated groups. Statistical analysis revealed that TA at 5.5...
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Posted by admin on Dec 31, 2018 in |
Atorvastatin alginate beads were prepared by ionic gelation method by using different curing agents and studied the different process variable like the effect of alginate concentration, the effect of rpm and curing agents on drug entrapment and to improve the bioavailability of the drug. The beads examined and qualified the all compatible studies. The amount of drug released in acidic medium was found to be less than alkaline medium and proved drug release is function of surrounding pH effect and beads prepared with aluminium chloride with physical mixture of sodium alginate and carbopol 934P at proportions of 3.3% produces more compacted, stabled and shows prolonged sustained release in comparison to barium chloride at same concentration of polymers. The size of beads, drug entrapment, and drug release depend upon variables like alginate concentration, type of curing agent, rpm, the valence of curing agent and addition of copolymer. The drug entrapment and physical stability will be improved by adding carbopol 934P along alginate polymer. DSC studies clarify Atorvastatin was dispersed in...
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Posted by admin on Dec 31, 2018 in |
The objective of this research was to develop a liquisolid (LS) formulation of dl-α tocopherol acetate with improved dissolution properties and evaluate its strength to excipient modifications as well as its stability. Microcrystalline cellulose (MCC) and sodium starch glycolate (SSG) was employed as carrier material and disintegrant respectively for preparing LS compacts. Colloidal silicon dioxide (CSD) was selected as coating materials. All the precompression parameters such as tapped density, bulk density, carr’s index, hausner’s ratio and angle of repose show the good flow properties of the formulation. UV and FTIR evaluated the physicochemical properties of the liquisolid system. All studies revealed that no interaction between drug and the carrier. The drug release rates of liquisolid compacts were specifically higher as compared to regular tablets. The specific surface areas of coating materials affected the flow properties of the blends, and the particle sizes of coating materials affected the dissolution rate. The selected formulation demonstrated stability for atleast 3 months. The F3 formulation is found to be the optimized formulation. The...
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Posted by admin on Dec 31, 2018 in |
This study aims to design resveratrol loaded microemulsion (ME) topical formulation for use in skin cancer. Encapsulation of resveratrol can improve its intrinsic solubility and enhance penetration into the skin for topical use as an alternative to injectables. Preformulation studies by DSC and FTIR confirmed the compatibility of chosen excipients with resveratrol. Resveratrol loaded microemulsion was developed using phase diagrams based on oleic acid, labrasol and transcutol P as the oil phase, surfactant and co-surfactant respectively. Optimization was based on the particle size and % drug diffused. Optimized resveratrol loaded microemulsion was transparent and stable without phase separation. Optimized ME had an average particle size of 243 nm, zeta potential -32.9 ± 2.5 mV and % drug content of 92.216 ± 1.056. Optimized resveratrol ME was incorporated into a gel base to form a microemulgel that exhibited a spreadability of 34.3 ± 0.34 gcm/s, the viscosity of 6000 ± 1.67 cps and sustained in-vitro and ex-vivo drug release. Amount of drug diffused (in-vitro) at the end of 24 h was...
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Posted by admin on Dec 31, 2018 in |
A novel method of estimation and validation of Sertaconazole nitrate (SER) by Reverse Phase-High Performance Liquid Chromatography coupled with Ultra-violet detection was developed which had high potential in determining drug concentration with more precision and high accuracy. The process of elution was conducted using Phenomenex C18 (250 mm × 4.6 mm i.d., 5.0 μm) using 0.01M monobasic sodium phosphate and acetonitrile in a ratio of 28:72% v/v as mobile phase at 4.5 pH and a flow rate of 1.0 mL/min. Detection was carried out using a UV detector at 260 nm. This precise method was linear between a range of 10 to 500 μg/ml with R2 close to one (0.999). The limit of detection (LOD) and limit of quantification (LOQ) of SER was found to be 0.1 μg/ml and 0.15 μg/ml respectively. The method was validated for accuracy, precision, linearity, LOD, LOQ, and robustness. Validation studies demonstrated that this HPLC method is simple, specific, rapid, reliable and reproducible. The 3-level 2-factor face-centred central composite design was employed using Design...
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