Posted by admin on Jan 31, 2019 in |
The main objective of the present investigation was to formulate and evaluate fast dissolving tablets of Roflumilast solid dispersions using a direct compression method. Roflumilast solid dispersions were prepared by solvent evaporation as well as melting method. Roflumilast is a selective, long-acting inhibitor of the enzyme PDE-4 and has anti-inflammatory effects. It is used orally in the treatment of chronic obstructive pulmonary disease (COPD). The roflumilast drug belongs to BCS class II drugs that have low solubility and high permeability. The current research work was focused on improving the aqueous solubility of Roflumilast using solid dispersion technique and enhancing the dissolution rate. Based on the results of solubility analysis, phosphate buffer pH 6.8 was chosen as the dissolution medium. The powder blend of Roflumilast solid dispersions was evaluated for flow characteristics. The fast dissolving tablets of Roflumilast solid dispersions were subjected to post-compression parameters such as weight variation, hardness, thickness, friability, drug content, wetting time, water absorption ratio, in-vitro dispersion time and in-vitro disintegration time and the results were...
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Posted by admin on Jan 31, 2019 in |
Madhuca longifolia var. latifolia belonging to the family Sapotaceae which was also known as Mahua and Butter tree. The present study was designed to identify the fatty acids present in oil and to analyze the elements present within the seed and seed cake. After extraction of oil, it was found that the seeds were high in oil content within the kernel. The oil percentage found in seed was highest recorded as 57.59%. In GCMS analysis of oil, the oleic acid which is monounsaturated fatty acid (45.11%) was recorded highest in amount compared to others. Elements within the seed and seed cake were analyzed using Energy Dispersive X-ray Spectroscopy. Concentrations of seven elements such as Calcium (35.53%), Carbon (33.56%), Oxygen (22.46%), Nitrogen (5.20%), Phosphorus (2.18%), Magnesium (0.23%) and Sodium (0.04%) had been determined in seed cake by Energy Dispersive X-ray Spectroscopy. The present study provides information about the availability of some essential minerals and fatty acids, which can be used as nutraceuticals and it may also help in developing the...
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Posted by admin on Jan 31, 2019 in |
Introduction: While many medical students have a special talent in psychiatry, attracting them to this specialty is a problem. The purpose of this study was to examine the impact of psychiatric education on the attitude of medical students on psychiatric patients. Method: In this observational study, 200 medical externs and interns were recruited. Before and after attending the 4-week psychiatry education course, the subjects were asked to express their attitude, knowledge, and experiences concerning psychiatry by completing the attitudes toward psychiatry (ATP-30) and the 6-item psychiatric experience, attitudes, and knowledge (PEAK-6) scales. Twenty-six subjects didn’t meet inclusion criteria or answered incompletely to the questionnaires Data were analyzed by t-test and paired t-test. All statistical assays were performed with SPSS19. Results: The average age of participants was 24.86 ± 1.85 years. Of the 174 students who were finally evaluated, 84 were externs (25 male, 59 female) and 90 were interns (35 male, 55 female). A significant statistical difference was found between the mean scores of PEAK-6 among the students before...
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Posted by admin on Jan 31, 2019 in |
Duck egg yolks contained fat and higher cholesterol than chicken eggs. A high-fat diet has caused obesity to impact for the development of diseases such as type II diabetes, stroke, atherosclerosis, hypertension, cardiovascular disease and certain forms of cancer. The purpose of using laboratory animals determined the effects of duck egg yolk to body weight, lipids profile, and atherosclerosis diseases. The study design is randomized post-test only control group design with Wistar rats. Twenty-seven rats were divided into three groups (nine rats per group): control, group I and II. The control group was given standard diet, and other groups received their respective agents (pellet duck egg yolk and raw duck egg yolk). After rats were treated for 30 days, blood samples were taken for examination of blood plasma lipids profile. These results have indicated that an increase in body weight of rats in both treatment as well as increase total cholesterol, LDL cholesterol, triglycerides, ratio of total cholesterol to HDL cholesterol, atherogenic index (AI), VLDL, and decreased in blood...
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Posted by admin on Jan 31, 2019 in |
The present study was carried out to assess the various phytochemical composition, GC-MS analysis, and antimicrobial potential of methanolic leaf extract of Alstonia scholaris (L.) R. Br. by using different solvents. Phytochemical analysis revealed the presence of alkaloids, coumarins, flavonoids, glycosides, phenols, quinines, saponins, tannins, steroids and terpenoids. Susceptibility testing by Agar well diffusion assay showed significant antimicrobial activity with ethyl acetate and methanol extracts of leaves against bacterial strains such as Bacillus subtilis, Bacillus cereus, Pseudomonas aeruiginosa, Staphylococcus aureus, Escherichia coli and fungal strain Candida albicans. The methanolic leaf extract exhibited better antimicrobial activity than ethyl acetate extract. The UV-Vis, FTIR, and GC-MS have been employed to characterize the bioactive compounds present in methanolic leaf extract of Alstonia scholaris. The crude extract was scanned in the wavelength ranging from 200-900 nm by using Perkin Elmer Spectrophotometer, and the characteristic peaks were detected. The FTIR spectrum confirmed the presence of alcohol, alkanes, amides, alkyl aldehydes, halogen, and aromatic compounds. The results of the GC-MS analysis provide different peaks determining...
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