Posted by admin on Dec 31, 2018 in |
This study aimed to assess the prevalence of the modifiable risk factors like prolonged kitchen stay, dietary pattern, cooking methods in outpatient (Housewives) bronchial asthma (BA) and chronic obstructive pulmonary disorder (COPD). This prospective observational study was carried out in Pulmonary Medicine Department in a Multispecialty Tertiary Care Hospital in Kerala, India. A total of 126 [BA (72) and COPD (54)] patients enrolled into the study as per global initiative for lung diseases (GOLD) standards. Hemoglobin concentration was measured by Sahli’s method. Predisposing factors for bronchial asthma (BA) and chronic obstructive pulmonary disorder (COPD) were monitored from the patient’s ecology. The univariate analysis showed a significant association between smoke exposure in kitchen and incidence of COPD and BA (P<0.05). The multivariate analysis showed the results demonstrated that risk for COPD group was significantly higher compared with BA group (P<0.05). Independent sample‘t’ test showed significant more time where BA patients stayed in the kitchen (P<0.05). The group that exposed to kitchen smoke more than 500 min per day was four...
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Posted by admin on Dec 31, 2018 in |
The purpose of the study was to determine the compatibility of Diacerein (DCN) with various pharmaceutical excipients used in the formulation of ultra-deformable vesicles by using the thermo-analytical technique, Fourier Transform Infrared Spectroscopy-Attenuated Total Reflectance (FTIR-ATR). Assessment of possible incompatibility between the drug and different excipients is an important parameter of preformulation studies. Diacerein was approved by FDA in 2008 for the treatment of osteoarthritis due to its inhibitory effect on pro-inflammatory cytokine including IL-6 and IL-1β. FTIR study of mentioned physical mixtures did not show any evidence of interaction in their solid state. Based on these results, all the excipients were found to be compatible with DCN as no new peak was observed spectra so that they can be further used in the formulation of transfersomal vesicles. FTIR spectra of transfersomal formulation showed a significant reduction in the intensity of peaks, which indicates the formation of vesicles. Moreover, all major peaks of DCN were found to be smooth indicating a strong physical interaction between drug, lipid, and surfactant...
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Posted by admin on Dec 31, 2018 in |
Cranberries (Vaccinium macrocarpon) contain many bioactive compounds and have some biological activities and beneficial health properties. This study aimed to screen phytochemicals of cranberry fruits from the different solvent, to estimate the total phenolic and flavonoid content of cranberry fruits and their antioxidant effect in-vitro by DPPH, superoxide and nitric oxide radical scavenging assay. Phytochemical screening of various extracts such as aqueous, ethanol, chloroform, acetone and petroleum ether of cranberry fruit extracts, revealed the presence of flavonoids, cardiac glycosides, phenols, coumarins, terpenoids, and betacyanin. The cranberry extracts were evaluated for phenol and flavonoid content with Gallic acid (GA) and Quercetin (Q) as standard. The optimum yield of phenol and flavonoid content were found in ethanol fruit extract 13.07 mg Gallic acid Equivalents (GAE)/g and 9.02 mg Quercetin Equivalents (QE)/g of cranberry. The cranberry extracts were evaluated for antioxidant activities by DPPH (1,1– diphenyl -2- picrylhydrazyl) radical scavenging assay. Among five different solvents used, maximum antioxidant activity was found in ethanolic fruit extract (81.4%) followed by others. The IC50 values of ethanolic cranberry extract in superoxide radical...
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Posted by admin on Dec 31, 2018 in |
Background: Actinodaphne hookeri Meissn. (Family Lauraceae), known as Pisa, is a moderate evergreen tree, found commonly in Chattisgarh, Western Ghats, Maharashtra, Karnataka, Orissa, Sikkim and North-Eastern parts of India. The leaves have been traditionally used in the treatment of diabetes and urinary disorders. The leaves were also known to possess potent antioxidant activity. Objective: Aim of the study was to investigate the in-vitro and in-vivo anti-diabetic activity of different extracts of leaves of Actinodaphane hookeri. Materials and Methods: The leaves of Actinodaphane hookeri were extracted successively with petroleum ether (AHP), chloroform (AHC), methanol (AHM) and water (AHA). Also, the leaves were extracted separately with alcohol (AHT). Extracts were subjected to phytochemical investigation and evaluated for its in-vitro anti-diabetic activity by α-glucosidase inhibitory activity, and in-vivo anti-diabetic activity was carried out in STZ-induced diabetic rats at two dose levels viz. 300 and 500 mg/kg doses for 21 days. Results: Phytochemical screening showed the presence of sterols, triterpenes, alkaloids, flavonoids, tannins, lactones and mucilages. The in-vitro α-glucosidase inhibitory activity was highest...
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Posted by admin on Dec 31, 2018 in |
Crocus pallasii subsp. haussknechtii grows in the west of Iran where local people consume the corm. It belongs to a saffron family (Iridaceae), which has shown several biological activities including cytotoxic and anti-angiogenesis properties. The corm (the nut and the surrounding fibers) and aerial parts of the species have shown anti-angiogenesis properties in HUV-EC-C cells previously; in the present study, the cytotoxic activity of different parts of the plant was evaluated. As people consumed the nuts, the aerial parts, nuts, and fibers were dried and ground and extracted separately. The methanol extract and petroleum ether, chloroform and methanol fractions were prepared by maceration and evaluated in A-549, HepG-2, MCF-7 and HT-29 cancer cell lines through MTT assay. The aerial parts showed no toxicity to any of the cancer cell lines up to the concentration of 100 μg/mL. The methanol extract and fraction of the fibers showed cytotoxicity to all cell lines while the methanol extract and fraction of the nuts and the chloroform fraction showed cytotoxicity to HepG-2 and...
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