Posted by admin on Apr 30, 2019 in |
Introduction: Melasma is a common facial pigmentary dermatosis in Indians. In spite of various treatment modalities, treatment of melasma is often challenging and recalcitrant. In this context, the present study was carried out to elucidate efficacy and safety of topical 10% Tranexamic acid (TXA) in melasma treatment. Materials and Methods: 40 Melasma patients with malar type were enrolled in the 12 weeks study. They were advised to apply 10% Tranexamic acid cream and placebo to the right and left cheek respectively along with sunscreen. MASI score, a subjective measurement was determined as a clinical outcome of study before and after treatment. Results: After treatment, there was a statistically significant reduction of baseline mean MASI score (Melasma Area and Severity Index score) of the right side of cheek (Tranexamic acid) 5.12 ± 1.78 to 4.01 ± 1.51 (P=0.000). Patient and physician satisfaction score revealed good response in the majority of the study population. Conclusion: Topical 10% Tranexamic acid is effective and safe for melasma...
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Posted by admin on Apr 30, 2019 in |
In the present study, we examined the effect of Silibinin on the accumulation of oxidative stress induced by MPTP by in-vitro. After decapitation, healthy rat brain was removed rapidly from the skull and rinsed with cold artificial cerebrospinal fluid (ACSF) which has been equilibrated with 95% O2 / 5% CO2 gas mixture. Group I brain was incubated in CSF serve as normal, Group II lenses brain was incubated in CSF and DMSO (10%) serve as disease, Group III brain was incubated with MPTP (1 ng/mL) Group IV brain was incubated in MPTP with bromocriptine (10 µg/mL), Group V brain was incubated in MPTP with Silibinin (10 µg/mL) Group VI brain was incubated in MPTP with Silibinin (20 µg/mL). After 1 h of incubation brain slices were homogenized in PBS buffer, pH 7.4 and estimated for protein content, LPO* and GSH as per the procedures. MPTP incubated brain LPO* levels were increased, and GSH activity decreased compared to normal group. Silibinin treated group brain LPO* levels were significantly decreased and...
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Posted by admin on Apr 30, 2019 in |
This article presents the development of a direct, simple and sensitive spectrophotometric method for the quantitative analysis of mebendazole (MBz), an anthelmintic medication in its pure and pharmaceutical forms. The method is based on the charge transfer (CT) interactions between MBz, an electron donor, and chloranilic acid (CA), 3,5-dinitrosalicylic acid (DNSA), and picric acid (PA), (all of which are p-acceptors). The products of the CT reactions exhibit new absorption bands at 409 and 310 nm for CA and DNSA in methanol, respectively, and at 402 nm for PA in dichloroethane. Following the optimization of the experimental conditions, linearity ranges for MBz concentrations of 2.00-120, 1.00-40.0 and 2.00-25.0 µg mL-1 were achieved for CA-MBz, DNSA-MBz, and PA-MBz, respectively. Furthermore, the limits of detection (LOD) and quantification (LOQ) were calculated. The method was used to determine the MBz concentrations of tablets with good accuracy and precision and without interference from common tablet...
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Posted by admin on Apr 30, 2019 in |
Introduction: Tracheal intubation is commonly facilitated by the use of muscle relaxants. Sevoflurane fulfills the criteria for successful rapid & smooth inhalational induction when muscle relaxants are contra-indicated. Aim: To compare the success rate of intubation characteristics, hemodynamic changes, the effectiveness of the trapezius squeezing test for an adequate condition for intubation. Method: A total of 150 patients of ASA grade I and II undergoing elective surgical procedures of aged 20-60 years were included in our study. Patients on MAO-inhibitors, antidepressants, and B-blockers were excluded. 50 patients in each group; were randomized to groups A, B, and C with sevoflurane dial concentration of 3%, 5%, and 8% respectively. Before induction, priming of the circuit with allotted group done with 3 times bag full and empty cycles. Once the trapezius squeeze test is negative, IPPV (intermittent positive pressure ventilation) was continued for another one minute. Mean arterial pressure (MAP) and heart rate (HR), jaw relaxation, body movements vocal cord position; complications were recorded for all patients. Results: The incidence of...
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Posted by admin on Apr 30, 2019 in |
Bacopa monnieri is a herb, known to possesses various pharmacological and medicinal properties. Aim: The objective of the study was to analyse the activity of Bacopa monnieri as an antipyretic, analgesic and anti-ulcerogenic agent. Methods: Indomethacin was used as the standard of comparison for this study. Animals were arbitrarily separated into three groups of six animals in each group. The first group was accorded saline, while the second group was administrated with the test drug Bacopa monnieri, and the third group received indomethacin. Hot plate test and acetic acid test were performed to analyze the analgesic activity of Bacopa monnieri. The antipyretic activity was evaluated by a yeast solution which was used to induce fever before administering the drugs. For the ulcerogenic activity, the rats were kept on a fast to induce ulcers and then the action of Bacopa monnieri was evaluated. HPLC analysis of the Bacopa monnieri sample was performed to evaluate the active components. Conclusion: It was possible to conclude that Bacopa monnieri showed significant analgesic, antipyretic...
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