Posted by admin on Feb 28, 2019 in |
In continuation of our efforts in the development of novel drugs, in the present article we have described synthesis of a series of novel azetidinones derivatives (4a-i) containing 5-(benzofuran-2-yl) and 1-phenyl-1H-pyrazole-3-carboxamide moiety, with excellent yields and without formation of undesirable side products from cyclo condensation reaction of N’- (benzylidene) -5- (benzofuran- 2- yl) -1 -phenyl -1H -pyrazole- 3-carbohydrazide derivatives (3a-i) with chloro acetyl chloride in the presence of triethylamine in DMF. Carbohydrazones of aryl aldehydes (3a-i) used as the starting compound was obtained by one-pot condensation of 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide (1) with various substituted aromatic aldehydes (2a-i) and a catalytic amount of acetic acid in ethanol. The structures of newly synthesized compounds have been established through elemental analysis and spectral studies like IR, 1H NMR, 13C-NMR and Mass spectra. All the synthesized compounds were screened for their in-vitro antibacterial activity against different strains of microbes such as S. aureus, E. coli, P. vulgaris and S. typhi at different concentration. The result of the bioactivity confirmed that most of the newly synthesized...
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Posted by admin on Feb 28, 2019 in |
Standardization can create trust and confidence in the products and increase market relevance. It is an essential requirement for the open exchange of information; without it, the network will simply not work. The practitioner, as well as the consumer, now seeks assurance from the manufacturer about the quality, safety, and efficacy of a readymade Herbal supplement or Ayurvedic formulations. An average person’s diet, lifestyle and other social habits, all who play important roles in disease and treatment, are completely different today. Hence, the earlier recommendations for herbs for specific disease states may not hold today unless validated in today’s times. Phenotypic changes in plant species. Hence the original pharmacological claims of these formulations need to be revalidated. Pharmaceutical research is aimed at meeting the medical needs of the population for whom appropriate therapeutic remedies are not available or at those that are available are unsafe for prophylactic use for various disorders. While meeting medical needs, research also has to ensure that the market needs for such exist. Vranropantaila is...
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Posted by admin on Feb 28, 2019 in |
Nanotechnology is an advancing technology expected to bring revolutionary changes in the field of life sciences including drug delivery. The advance in nanotechnology helps in the preparation of new pharmaceutical formulations with high benefits. One of its approaches is to stabilize the niosomal drug delivery system without affecting its properties have resulted in the development of proniosomes, a drug carrier. Proniosomes are solid colloidal particles which may be hydrated immediately before use to yield aqueous noisome dispersions similar to those produced by conventional methods. These proniosomes minimize the problems related to conventional niosomes such as aggregation, fusion, leaking and provide additional convenience in transportation, distribution, storage and dosing with enhanced stability. Ofloxacin loaded maltodextrin based proniosomes were prepared by a slurry method with a different surfactant to cholesterol ratio. The formulated proniosomes possessed good flow property and smooth surface confirmed by SEM study. FTIR spectra’s confirmed no interactions between drug and carrier. The niosomal dispersions were formulated and further evaluated for particle size, polydispersity index (PDI), zeta potential, TEM,...
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Posted by admin on Feb 28, 2019 in |
This study aimed to investigate the protective effect of flaxseed oil against hepato-renal toxicity induced by methotrexate. Rats treated with methotrexate exhibited elevations in the levels of AST, ALT, ALP, γGT, LDH, urea, creatinine, uric acid, and bilirubin. Furthermore, the levels of MDA, NO and the relative ratio of the gene expression of COX-2 and iNOS were significantly increased, accompanied by a decrease in the total protein, SOD, GPx, total thiol as well as the GSH content. Alterations in the lipid profile and hepato-renal histology were observed in rats treated with methotrexate. Also, up-regulation of α-SMA and loss of DNA bands integration were observed in methotrexate-treated rats. However, the oral treatment of flaxseed oil exhibited a protective effect against methotrexate toxicity in rats that could be attributed to its potent antioxidant, anti-inflammatory, and anti-apoptotic...
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Posted by admin on Feb 28, 2019 in |
Drug release properties from dosage forms can be modified by using many rate controlling polymers. Such controlled release properties from carrier systems are desirable since efficient drug delivery is achieved. The aim of the present study was to develop efficient chitosan nanoparticles loaded with rosmarinic acid (RA) and evaluate its drug release properties and wound healing efficiency in rats. Antimicrobial activity and wound healing effect of RA is well established and reported by many workers. Chitosan is also well known for possessing rate controlling properties. For proper application over wounds, the nanoparticles were incorporated into carbopol 940 hydrogel. A fourteen-hour in-vitro release study was carried out to evaluate the drug release efficiency and drug release kinetics of the nanoparticles. Other parameters evaluated were particle size, polydispersity index (PDI), zeta potential, morphology. Carbopol 940 hydrogel was evaluated for optimum viscosity (18.43 ± 1.7), swelling (250 ± 7.9) and spreadability (31 ± 1.5). The in-vivo study was carried out in three groups of animals, those treated with gel containing RA loaded...
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