Posted by admin on Nov 30, 2018 in |
The clinical efficacy of glucocorticoids is dependent on its potency and on its ability to be absorbed in to the skin and therefore, reach its site of action. Colloidal drug carriers such as solid lipid nanoparticles could target glucocorticoids to the epidermis, where the anti-inflammatory action takes place. Topical corticosteroids have long been the chronic stage in the treatment of steroid responsive dermatitis. Creams containing Clobetasol-17-propionate (CP) as active ingredients are categorized as super potent class I topical dermatological corticosteroids. For the drug molecule to reach the cutaneous microcirculation, enhance, the systemic circulation, have to transverse both the lipophilic stratum cornium and much more viable epidermis. Various formulations of solid lipid nanoparticles were formulated using various ingridients viz. Compritol 888 ATO, lutrol F68, tween 80 etc. the cream formulations were evaluated as there pH, drug content, viscosity, spreadability, extrudability and percent drug release. In-vitro diffusion study using cellophane membrane as well as rat skin mounted in Franz diffusion cell. CP was analyzed spectrophotometrically at 240...
Read More
Posted by admin on Nov 30, 2018 in |
Synthetic organic compounds, containing relatively higher number of nitrogen attracting interest in the current medical research due to their utility in chemotherapy. The development of new medicines with more number of nitrogen atoms in their structural framework is an important challenging task for medicinal chemists. The lipophilicity of Mannich bases and their metal complexes enables them to be more potent novel medicines and acquire huge interest among medicinal chemists. We report here the synthesis of novel lead structure of new Mannich base and its complexeswith the variety of transition metals such as Co(II), Mn(II), Ni(II), Cu(II) and Zn(II) and evaluated them for DPPH free radical scavenging and anti-inflammatory activity. As the Mannich base from the combinations 4-nitrobenzaldehyde, morpholine and nicotinamide was not yet reported, the new Mannich base, N-[Morpholino(4-nitrophenyl)methyl]nicotinamide (NMN), was synthesized from this combination. The ligand and its complexes were characterized using various analytical (Chemical assays, Elemental analysis and TLC) and spectral studies (FT-IR, UV-Visible, 1H NMR, 13C NMR, Mass and...
Read More
Posted by admin on Nov 30, 2018 in |
Infectious bronchitis virus causes infectious bronchitis in chickens. Variant 2 is a virulent strain circulating in the Middle East, Iraq is one of them, which harbor the strain at high rate causes a severe economic loos. Sequences of variable S1 glycoprotein were collected, consensus sequence derived and used in computational epitope vaccine design. The results gave one B cell epitope “DFMYGSYHPKCDFRPETIN” with very high antigenic score. T cell (CTL) epitope prediction produced four epitopes “QTQTAQSGY, FNFSFLSSF, FSFLSSFVY, NSLSVSLAY” with desirable criteria and react with many MHC I alleles, and docked with BF2*21:01 and BF2.0401 chicken MHC I molecules. T helper cell epitopes prediction gave eight epitopes “GYYNFNFSFLSSFVY, KFIVYRETSVNTTLV, LTNFTFTNVSNALPN, TG GVNTINIYQTQTA, TINIYQTQTAQSGYY, YNFNFSFLSSFVYKQ, NNGL WFNSLSVSLAY, NGLWFNSLSVSLAYG” reacting with many MHC II alleles. These epitopes can be used for preparation of vaccine to be investigated in wet lab...
Read More
Posted by admin on Nov 30, 2018 in |
TAT (Trans-activator-Transcription Protein) is a viral protein encoded by the TAT gene in HIV-1-which is a lethal subtype of HIV (Human immunodeficiency Virus). It is vital for transcription of the viral genome. Previous studies show that in Human, TAT is a toxin-producing protein allowing cell death in obtained from QSAR studies, best quassinoid compounds were used to find the highest binding affinity compound by performing normal T-cells. Thereafter allows for progression towards AIDS (Acquired immunodeficiency syndrome). Traditionally, herbal medicines have played a vital role in the treatment of many diseases and ailments. Likewise, Quassinoids from the plant family Simaroubacaea, possess insecticidal, antimalarial and anticancer properties. Although studies have been conducted to find anti-HIV activities against other HIV-1 proteins, there are no traces of studies against Trans-activator-Transcription protein (1JFW). The main objective of this study is to find an efficacious inhibitor against a synthetic HIV TAT protein (PDB- IJFW). After a thorough literature survey, the molecular and biological activity of quassinoid phytoconstituents has been recorded for QSAR (Quantitative structure-activity relationship)...
Read More
Posted by admin on Nov 30, 2018 in |
Background: Lung Cancer is the commonly diagnosed neoplasm in males in India. The main histological types of lung cancer are squamous cell carcinoma, adenocarcinoma, small cell carcinoma and large cell carcinoma. However, histological types may vary with the changes in geographical region, smoking status and other social factors. This study aimed to find out the relationship of smoking and histological types of lung cancer. Methods: We performed a prospective observational analysis of 238 histopathologically proven cases of lung cancer in Malappuram district of Kerala during the period of 2017 and 2018. Results: A total of 238 patients involved, 82.77% were males and the male to female ratio was 4.8:1. Of the 238 patients, 166 patients (69.75%) had history of smoking in their life time and 72 patients (30.25%) were non-smokers. In males, majority of patients were smokers (83.25%) and in female patients, 39 (95.12%) were non-smokers. Among Smokers, squamous cell carcinoma (63.25%) is the most common histological type followed by adenocarcinoma (22.89%). In case of non-smokers, the status is...
Read More
