Posted by admin on Jan 31, 2019 in |
Rosella (Hibiscus sabdariffa L.) calyx traditionally used to treat various diseases. There is limited evidence based could be found including the efficacy and safety. The present study was aimed to investigate the effects of subchronic administration of Rosella calyx extract on the renal function of female Sprague Dawley (SD) rats. The rosella calyx was extracted by 70% ethanol and evaporated with a rotary evaporator to get concentrated extract. The Sprague Dawley rats were randomly divided into five groups including control group which was given CMC Na 0.5% and treated groups were administered orally with the extract of 50, 100, 200 mg/kg bw for 35 days. The satellite group was conducted for observing the reversibility, the observation in this group was conducted 14 days after 35 days of treatment. The biochemical function including ureum and creatinine was analyzed from a blood sample using enzymatic UV-test, and creatinine level were observed by the Jaffe method. The histopathology profile of kidney was observed with Hematoxylin and Eosin staining and followed by microscopic...
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Posted by admin on Jan 31, 2019 in |
This study was aimed at formulating topically applied Chlorpheniramine maleate gel (CPM gel). Combined effects of propylene glycol and polyethylene glycol as permeation enhancers were investigated using response surface methodology. The formulated gels were characterized for various formulation attributes including viscosity, homogeneity, pH, spreadability and accelerated stability studies (40 ± 0.5 °C / 75% RH). In-vitro studies were also conducted using silicone sheets and rat skin as model membranes. The permeation study revealed that an increase in the drug permeation across model membranes was due to an increasing concentration of enhancers. Based on formulation attributes and permeation parameters, FM6 was identified as optimized formulation. The drug release from optimized formulation followed the first order release kinetics. Draize’s skin irritation test was conducted on healthy human volunteers to elucidate the safety profile of the formulations. Pharmacokinetic profiling of optimized gel was also conducted, and finally, the optimized gel was subjected to anti-allergenic challenge. Pharmacokinetic studies revealed that topical application produced comparable results with the oral delivery and the optimized gel...
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Posted by admin on Jan 31, 2019 in |
Introduction: Antibiotics suppress the growth of or kill another microorganism at very low concentrations. Therefore this is the one of the supreme invention need of this era. Most bacteria are becoming resistant to various antibiotics, make a limitation for treating minor and major infectious. Hence, determining the resistance patterns in the geographical area will help in choosing and use of the effectiveness of antibiotics. Methods: It is a prospective observational study carried out in 167 patients in an inpatient Department of Surgery and Medicine between October 2017- April 2018. The enrolled patient data was collected in data collection form and subjected to descriptive statistics. Results: Among 167 observed cases 71.8% was male, and 28.2% was female. The majority of the patient was at the age group of 61-70 years (28.1%). E. coli 27.5% is the most commonly found organism followed by Klebsiella species 16%, E. coli with ESBL producer 8%. Amoxiclav 44.3% was found as the most resistant antibiotic followed by Ampicillin 43.1%, Cefotaxime 37.7%, Ceftazidime 31.1%, Ciprofloxacin 31.1%,...
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Posted by admin on Jan 31, 2019 in |
The main objective of the present investigation was to formulate and evaluate fast dissolving tablets of Roflumilast solid dispersions using a direct compression method. Roflumilast solid dispersions were prepared by solvent evaporation as well as melting method. Roflumilast is a selective, long-acting inhibitor of the enzyme PDE-4 and has anti-inflammatory effects. It is used orally in the treatment of chronic obstructive pulmonary disease (COPD). The roflumilast drug belongs to BCS class II drugs that have low solubility and high permeability. The current research work was focused on improving the aqueous solubility of Roflumilast using solid dispersion technique and enhancing the dissolution rate. Based on the results of solubility analysis, phosphate buffer pH 6.8 was chosen as the dissolution medium. The powder blend of Roflumilast solid dispersions was evaluated for flow characteristics. The fast dissolving tablets of Roflumilast solid dispersions were subjected to post-compression parameters such as weight variation, hardness, thickness, friability, drug content, wetting time, water absorption ratio, in-vitro dispersion time and in-vitro disintegration time and the results were...
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Posted by admin on Jan 31, 2019 in |
Madhuca longifolia var. latifolia belonging to the family Sapotaceae which was also known as Mahua and Butter tree. The present study was designed to identify the fatty acids present in oil and to analyze the elements present within the seed and seed cake. After extraction of oil, it was found that the seeds were high in oil content within the kernel. The oil percentage found in seed was highest recorded as 57.59%. In GCMS analysis of oil, the oleic acid which is monounsaturated fatty acid (45.11%) was recorded highest in amount compared to others. Elements within the seed and seed cake were analyzed using Energy Dispersive X-ray Spectroscopy. Concentrations of seven elements such as Calcium (35.53%), Carbon (33.56%), Oxygen (22.46%), Nitrogen (5.20%), Phosphorus (2.18%), Magnesium (0.23%) and Sodium (0.04%) had been determined in seed cake by Energy Dispersive X-ray Spectroscopy. The present study provides information about the availability of some essential minerals and fatty acids, which can be used as nutraceuticals and it may also help in developing the...
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