Posted by admin on Jun 30, 2024 in |
The escalating use of medications among children presents a global concern, with self-medication by parents increasingly prevalent. This study investigates the prevalence of self-medication practices among parents of children aged 1 to 12. Methods: Over six months, 200 participants who self-medicated their sick children were enrolled. The study, conducted at King Koti District Hospital in Hyderabad, utilized a self-structured questionnaire targeting paediatric patients aged 0-12. Results: Most participants were parents aged 20 to 40 years, predominantly fathers (65.5%), with most having two children (36%) aged 2-4 years. Fever was the most commonly reported condition (22.5%). While a significant proportion expressed confidence in selecting over-the-counter (OTC) medications (41.5%), NSAIDs and analgesics were the primary choices. Safety perceptions varied, with 25% considering OTC medications generally safe and 13% entirely safe. Discussion: The study highlights parental awareness of risks associated with self-medication, notably allergic reactions (49.5%) and over dosage (57%). It provides insights into parental self-medication practices in paediatric care, emphasizing the need for tailored interventions and educational efforts on safe medication...
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Posted by admin on Jun 30, 2024 in |
Aim: This study aims to explore the potential of transdermal drug administration as a viable alternative to conventional medication delivery systems. Specifically, the focus is on the development and evaluation of transdermal patches containing Lamivudine and Stavudine for the treatment of AIDS. The overarching objectives include extending drug release duration, reducing administration frequency, and enhancing patient compliance. Material & Methods: The formulations under investigation are meticulously designed using a combination of HPMCK15M, PVPK30, and EC in varying ratios. The patches are subjected to a thorough assessment, encompassing critical parameters such as film thickness, tensile strength, and drug content homogeneity. The incorporation of Tween 80 and dimethyl sulfoxide as plasticizer and penetration enhancer is a key methodological consideration for optimizing the transdermal patches. Additionally, the study explores the impact of natural permeation enhancers, such as oleic acid, eucalyptus oil, and clove oil, on drug permeation and release kinetics. Results: The outcomes of the study reveal promising findings, with the transdermal patches exhibiting favorable characteristics, including optimal film thickness, tensile strength,...
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Posted by admin on Jun 30, 2024 in |
The present study aimed to evaluate the effect of hydroalcoholic extract of Sida spinosa L. (HYSS) in antigen induced rheumatoid arthritis in mice by intra articular administration of Bovine serum. Rheumatoid arthritis was induced by the mixture of antigen (Bovine serum albumin) and adjuvant (Imject alum) in 1:1 ratio on 1st, 7th and 21st day as an induction period. The mixture of antigen and adjuvant caused the joint destruction, chronic inflammation of synovium, pannus formation, erosion of bones and cartilage in mice. The HYSS administered at three different concentrations 100, 200 and 400 mg/kg,p.o. as test and Indomethacin (2 mg/kg, p.o) as reference standard for next 20 days as a treatment period in arthritis induced mice. The study was conducted for total 41 consecutive days as initial 21 days of induction and next 20 days as treatment period. Progression of arthritis in different group of animals was evaluated by biochemical parameters, histological changes, antioxidant activity and radiographic analysis in overall joint structure. HYSS at 200 and 400 mg/kg significantly...
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Posted by admin on Jun 30, 2024 in |
Sagadevi nei is a Siddha polyherbal formulation indicated for Neerkattu and Neersurukku. The main ingredient of the formulation is Vernonia cinerea, belonging to the family Fabaceae, which has been proven scientifically to exhibit renal tubular regrowth. Based on Literature, each ingredient of the mixture has nephroprotective, diuretic, antioxidant, and anti-inflammatory properties. Cisplatin is a metallic compound antineoplastic drug with a known side effect of renal damage. The present study aims to elucidate the attenuative effect of Sagadevi Nei against Nephrotoxicity. MTT assay is a sensitive and reliable indicator of cellular metabolic activity. This study is done in-vitro by MTT assay in Human Embryonic Kidney (HEK) 293 cell lines. The toxicity was induced by cisplatin and the amount of cell damage was calculated. The Nephroprotective activity assessed by MTT Assay against cisplatin-treated HEK293 Cell lines co-treated with Sagadevi Nei showed an increase in the percentage of cell viability from 49.82% to 67.87% in a dose-dependent...
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Posted by admin on Jun 30, 2024 in |
The present study examined the potential of horsegram yush/ broth on preventing growth of calcium hydrogen phosphate dihydrate (Brushite) crystals in vitro. Crystal length was measured daily over a period of 11 days Two types of yush were tested (a) akruth yush made with only salt or (b) kruth yush with Trikatu consisting of equal proportions of long pepper (Piper longum), black pepper (Piper nigrum), and dry ginger (Zingiber officinale). These yush were tested also with addition of different concentrations of citric acid or lemon juice. The yush were prepared as prescribed in Ayurvedic texts. Kruth yush significantly inhibited crystal growth and was more effective than akruth yush. Addition of citric acid to the kruth yush, reduced crystal size from Day 2 and continued until Day 11. Percent reduction was more with higher citric acid concentration (302% with 0.001 M, 35.5% with 0.0055 M and 50.2% with 0.01M citric acid). However, citric acid alone with horsegram yush did not reduce crystal size significantly. Lemon juice was effective in reducing...
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