Posted by admin on Nov 30, 2018 in |
Evaluation of different natural and synthetic polymers as protective layer polymers in the manufacturing of control release multi-unit pellet tablets, Tolterodine Tartrate was selected as a model drug with aqueous ethylcellulose suspension is used as control release polymer. Tolterodine Tartrate is highly soluble BCS Class- I molecule, hence selected aqueous solution layering method for drug loading in Fluid bed processor, Optimized formulation was manufactured by using seal coating on microcrystalline cellulose pellets followed by drug loading and control release coating applied by using solution and suspension layering method respectively in Fluid bed processor. Given coating on these functional coated pellets with different natural and synthetic polymers like Klucel, Polyethylene glycol 6000, Hypromellose 5 cps, Guar gum, and Xanthan gum. Evaluated these pellets for physical characterization, DSC, SEM and comparative in-vitro dissolution profiles. Drug release profiles of Control release MUPS tablets containing protective layer coating was compared to those control release pellets and f2 values observed was more than 50 with Klucel, Polyethylene glycol 6000, Hypromellose 5 cps, Guar gum,...
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Posted by admin on Nov 30, 2018 in |
In the present work the nanoliposomes prepared by using REV and MEU methods were coated with different concentration of chitosan solutions. The main objective behind this work was to assess the physical properties, stability and in vitro release of uncoated and chitosan coated nanoliposomes of gefitinib. The existence of a covering on the exterior of nanoliposomes was confirmed by the modification in particle size and zeta potential. The chitosan coated nanoliposomes had shown significantly slow in-vitro drug release than uncoated nanoliposomes that confirmed the increased stability of nanoliposomes. The transmission electron microscopy, particle size analysis, FTIR studies, DSC analysis, and zeta potential studies were used to investigate the characteristics of uncoated and chitosan-coated nanoliposomes to develop and further optimize nanoliposomes that are directed for their systemic pharmacological applications. Stability studies and cytotoxicity studies of uncoated and chitosan coated nanoliposomes were performed. Chitosan coated formulations were found to be more stable and more cytotoxic than uncoated formulations. The ideal temperature was found to be 4...
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Posted by admin on Nov 30, 2018 in |
Disorders caused by excessive use of alcohol known as alcohol use disorders (AUD) are the most common cause of liver diseases including cirrhosis. In adults, the most common cause of death is alcohol consumption which leads to an array of alcoholic liver diseases (ALD). Present study has been conducted to investigate the hepatoprotective activity of Bixa orellana L. (BO) seed extract against acute ethanol-induced hepatotoxicity in rats. The characterization of BO seed extract was performed using standard biochemical analysis. 50% ethanolic extract of Bixa orellana (BOE 200 and 400 mg/kg body weight) was administered daily for 8 days in experimental animals for the assessment of hepatoprotective activity. To develop hepatotoxicity, animals were orally administered with alcohol (40%) 12 ml/kg at 2 h after the doses of BOE every day for eight consecutive days except the rats of normal group. The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase, alanine aminotransferase, alkaline phosphatise, bilirubin, albumin, cholesterol and lactate dehydrogenase. However, the results demonstrated that the treatment with...
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Posted by admin on Nov 30, 2018 in |
Background: Medical Intensive Care Unit (ICU) can be a potential place for Pharmacovigilance due to high frequency of Adverse Drug Reactions (ADRs). Regular evaluation can help in understanding the pattern of ADR and reduce the incidence of it. Aims and Objectives: To evaluate incidence of ADRs in patients receiving various modes of treatment at medical ICU of our tertiary care hospital and classify them. Materials and Methods: Study was carried out by actively observing 500 patients admitted at medical ICU over a period of 18 months. Suspected ADRs were reported and classified. Association between various factors was carried out by chi square test. Results: Total 59 (11.8%) ADRs were reported. Most common was hypotension 8 (13.56%) followed by headache 7 (11.86%). Highest group responsible for ADRs was fibrinolytic drugs 14 (23.73%). Coagulation and cardiovascular systems were commonest to involve with incidence rate of 16 (27.12%) and 14 (23.73%) respectively. Commonest type was A with incidence rate of 42 (71.19%). Significant association was noted between no. of drugs and increased...
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Posted by admin on Nov 30, 2018 in |
Rosa damascena Mill. also known as Damask rose, Persian rose or Gul-e-Muhammadi of Rosaceae family is an aromatic small plant cultivated all over the world for its visual beauty, fragrances and therapeutic potential. The plant is rich in tannins, flavonoids, glycosides, carboxylic acids and ascorbic acid. In addition to its aromatic properties, the plant possesses laxative, anti-oxidant, anti-bacterial, wound healing, skin health, cardiotonic, hypnotic and cough suppressant activities. The medicinal uses reported from this plant are of its methanolic, ethanolic or chloroformic extract and of its essential oil. This research is planned to investigate the analgesic and anti-inflammatory potential of aqua distillate of Rosa damascena Mill. flower in two different doses i.e. 250 mg/kg and 500 mg/kg using Hot Plate, Tail Flick and acetic acid induced paw-edema method. Also as recent studies reported that alcoholic extract of Rosa damascena possesses analgesic activity and aqueous extract does not, so this study also aimed to evaluate these activities after its distillation in aqueous...
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