Posted by admin on Jan 31, 2019 in |
Siddha system of medicine is a traditional medicinal system being followed mainly in South India. It is better known as one among the AYUSH medicinal system. The present study aims to standardize the Siddha poly-herbal formulation Panchabakiya chooranam (PBC), which is mentioned in the Siddha classical text Anuboga vaidya Brahma ragasyam indicated for stomach burn, burning sensation in anus and diarrhea. Accordingly, PBC was studied through Inductively Coupled Plasma Optical Emission Spectrometric analysis (ICP-OES) and Fourier Transform Infrared Spectroscopy (FTIR) techniques to identify the metals and functional groups present in it. Results showed that the sample contains elements such as Calcium, Iron, Sodium, Potassium, and Phosphorous. Among the detected elements Phosphorus was present in a maximum concentration, and iron was in lowest concentration. Moreover, the toxic metals namely, Mercury, Arsenic, Cadmium, Nickel, and Lead were in Below Detectable Level, which ensures that the drug is safe to consume. Besides, functional groups such as Alcohols, alkanes, amides are identified using IR...
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Posted by admin on Jan 31, 2019 in |
The aim of the present investigation was to enhance the dissolution of poorly water-soluble drug Ramipril (BCS – II) drug through Liquisolid compact. The liquisolid compacts were prepared with a varied quantity of liquid and powder ingredients using microcrystalline cellulose as a carrier, Aerosil 200 as a coating material, polyethylene glycol 400, propylene glycol and tween-80 as liquid vehicles, HPMC as additives to increase loading capacity. The required quantities of ingredients for the compressible admixture were calculated using various mathematical models. The in-vitro release characteristics of different dissolution conditions were performed. All formulated systems were assessed for precompression parameters like flow properties, FTIR analysis, X-ray diffraction (XRD), differential scanning calorimetry (DSC), and post-compression parameters like content uniformity, weight variation, hardness, friability, disintegration test, wetting time and in-vitro dissolution studies. As liquisolid compacts demonstrated significantly higher drug release rates, thereby indicating a promising strategy in improving the dissolution of poorly water-soluble drugs and formulating immediate release solid dosage...
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Posted by admin on Jan 31, 2019 in |
The purpose of the research was to develop and evaluate metronidazole loaded HPMC K15M mucoadhesive microcapsules for sustained drug release at the gastric mucosa. Metronidazole mucoadhesive microcapsules were formulated by ion gelation technique using 32 factorial designs. A 32 full factorial designs were used to derive a statistical equation, ANOVA analysis, contour plots, and 3D response surface plots. Different polymer ratios of HPMC K15M and sodium alginate were used to formulate nine formulations (F1 to F9) of HPMC K15M loaded mucoadhesive microcapsules of metronidazole. In-vitro drug release and mucoadhesion were carried out by USP29 type-II tablet dissolution test apparatus and disintegration tester using goat stomach mucosa. The formulation was characterized by determining possible drug-polymer interaction using FT- IR, the percentage of yield, particle size, the percentage of entrapment efficiency, swelling index, the percentage of mucoadhesion and percentage of drug release. FT-IR spectroscopy result shows the interaction between the drug and polymers combined. The optimized formulations F9 exhibited high drug entrapment efficiency of 92.07 ± 0.02%, particle size of 852.46...
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Posted by admin on Jan 31, 2019 in |
Swietenia mahagoni (L.) Jacq. belongs to the Meliaceae family and it is native to the West Indies. It was introduced to India in 1975 and now grown in any parts of India. Biological activities of the plant are due to the abundance of phenolic compounds including different terpenoids and limonoids. The plant possesses various secondary metabolites which are responsible for its anti-bacterial, anti-fungal, anti-malarial, anti-diabetic anti-oxidant, anti-ulcer, anti-viral, anti-diarrhoeal, anti-pyretic and anti-inflammatory properties. This antimicrobial activity encouraged to work on identification of phytochemical and antimicrobial investigation of this herbal plant. The seeds and barks of Swietenia mahagoni is subjected to phytochemical screening for secondary metabolites and disk diffusion method for its antimicrobial activity against standard MTCC strains, two bacteria namely Staphylococcus aureus (gram+) (MTCC no. 6908), Escherichia coli (gram-) (MTCC no. 77) and one fungus Aspergillus niger (MTCC No.1344) were used for the study. The qualitative phytochemical tests reveal the presences of phytocompounds including alkaloids, terpenoids, tannins, and glycosides as major active constituents. The seed and bark extracts exhibit positively significant antimicrobial...
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Posted by admin on Jan 31, 2019 in |
Rheumatic heart disease (RHD) is a major burden in developing countries and leads to heart valve damage resulting from acute rheumatic fever (ARF). RHD and its complications cause more than 1.4 million deaths per year, globally. The mortality in RHD depends on the factors related to socio-economic status and tertiary care, especially in developing countries like India. In this study, a comparative analysis of the socio-economic status of RHD patients in a tertiary care hospital is done, and the prevalence of RHD in different aged patients is explored. A total of 96 RHD patients were included in the study with a mean age of 50.89 ± 14.62 (30-79) years. The average heart rate (HR) and ejection fraction (EF) of RHD patients were 90.15 ± 24.77 (46-160) and 55.61 ± 10.93 (23-70), respectively. It was found that only 87.50% patients were a complaint on follow up visits, out of which 39.58% were in age group 30-45 years, 37.50% were in age group 46-60 years, and 22.92% were above 60 years....
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