Posted by admin on Jan 31, 2019 in |
Several type II diabetic models have been developed to evaluate the effects of potential antidiabetic agents. However, there seems to be a paucity of literature evaluating the characteristics of diabetes-induced with fructose and alloxan. Therefore, this study was conducted to characterize fructose-alloxan diabetes. Thirty rats were grouped equally into Control, Fructose and Fructose plus 150 mg/kg-IP alloxan. Twenty percent fructose solution was freely administered via gavage drinking for 2-weeks before alloxan. After that, rats were observed for 14-weeks. Lee-index of obesity was determined using body-weights and nose-anal lengths. Fasting Plasma Insulin (FPI) and blood glucose (FBG) were determined using ELISA and glucometer. Insulin Resistance (IR), Insulin sensitivity (IS) and Beta cell function (BCF) were evaluated via the Homeostasis Model Assessment (HOMA). Response to metformin and Insulin were assessed. Data were analyzed using ANOVA and Fishers LSD post-hoc test at α0.05. Administration of alloxan to rats pre-treated with fructose elevated FBG (378.3 ± 40.0 vs. control 60.8 ± 2.5 mg/dL), which was not reduced significantly by insulin (351.8 ± 30.4...
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Posted by admin on Jan 31, 2019 in |
Cissus latifolia Lam. (Vitaceae) is a woody climber with leaf-opposed tendrils. It is a medicinal plant used in the traditional system of medicine for the treatment of various ailments. The present study focused on the identification and qualitative determination of phytoconstituent types and establishment of the HPTLC fingerprint profile of the hot and cold extracts of C. latifolia. Preliminary phytochemical screening was done to identify the class of compounds present. HPTLC analyses of eight different extracts were carried out with the most suitable mobile phase system using the Camag HPTLC instrument consisting of Linomat- V automated spotter having a 100 μl syringe connected to a nitrogen cylinder, twin-trough developing chamber, scanner-III and viewing cabinet with dual wavelength UV lamps (Camag, Muttenz, Switzerland). Qualitative phytochemical screening revealed the presence of flavonoids, coumarins, tannins, alkaloids, steroids, terpenoids, saponins, quinines, anthraquinones and phenol in the stem of C. latifolia. The HPTLC profiling of eight different extracts showed the presence of alkaloids, flavonoids, phenols, saponins, and tannins with different Rf values. The results...
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Posted by admin on Dec 31, 2018 in |
Objective: To evaluate and compare pH and titrable acidity (TA) of various commonly consumed commercially available soft drinks. To evaluate and compare the weight of enamel dissolution and surface micro-hardness of the tooth after exposure to commonly consumed commercially available soft drinks. Methods: 60 human enamel specimens were randomly divided into 5 groups: Group 1: Kinley water (control), Group 2: Pepsi cola, Group 3: Urzza the liquid charger, Group 4: Tropicana orange delight, Group 5: Patanjali amla amrit. For the five solutions pH and TA was calculated. Each of the specimens were then pre-weighed and exposed to the soft drink for 14 days and weighed again. The mean weight difference was calculated for all of the samples. The same samples were subjected to the micro-hardness test (Vickers hardness number). Results: The pH of all the test drinks ranged from 2.55 to 3.74, which is far below critical pH. The pH and TA of carbonated drinks were statistically significantly lower than non-carbonated groups. Statistical analysis revealed that TA at 5.5...
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Posted by admin on Dec 31, 2018 in |
Atorvastatin alginate beads were prepared by ionic gelation method by using different curing agents and studied the different process variable like the effect of alginate concentration, the effect of rpm and curing agents on drug entrapment and to improve the bioavailability of the drug. The beads examined and qualified the all compatible studies. The amount of drug released in acidic medium was found to be less than alkaline medium and proved drug release is function of surrounding pH effect and beads prepared with aluminium chloride with physical mixture of sodium alginate and carbopol 934P at proportions of 3.3% produces more compacted, stabled and shows prolonged sustained release in comparison to barium chloride at same concentration of polymers. The size of beads, drug entrapment, and drug release depend upon variables like alginate concentration, type of curing agent, rpm, the valence of curing agent and addition of copolymer. The drug entrapment and physical stability will be improved by adding carbopol 934P along alginate polymer. DSC studies clarify Atorvastatin was dispersed in...
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Posted by admin on Dec 31, 2018 in |
The objective of this research was to develop a liquisolid (LS) formulation of dl-α tocopherol acetate with improved dissolution properties and evaluate its strength to excipient modifications as well as its stability. Microcrystalline cellulose (MCC) and sodium starch glycolate (SSG) was employed as carrier material and disintegrant respectively for preparing LS compacts. Colloidal silicon dioxide (CSD) was selected as coating materials. All the precompression parameters such as tapped density, bulk density, carr’s index, hausner’s ratio and angle of repose show the good flow properties of the formulation. UV and FTIR evaluated the physicochemical properties of the liquisolid system. All studies revealed that no interaction between drug and the carrier. The drug release rates of liquisolid compacts were specifically higher as compared to regular tablets. The specific surface areas of coating materials affected the flow properties of the blends, and the particle sizes of coating materials affected the dissolution rate. The selected formulation demonstrated stability for atleast 3 months. The F3 formulation is found to be the optimized formulation. The...
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