Posted by admin on Nov 30, 2018 in |
Introduction: Monitoring and assessment of the medication errors in hospitals can help in reducing the medical treatment costs and minimizing the risk of harm to the patients. This study aims to determine the frequency and types of medication errors and to assess the consequences of the errors which occurred. Materials and Methods: A prospective, cross- sectional study was conducted in the ICU and medicine wards at a tertiary care hospital, India. The in-patient’s case sheets were reviewed on a daily basis, and were evaluated to find out any suspected medication errors. Results: During the study period of 6 months, 700 prescriptions were analysed for medication errors. Among them, 300 medication errors were identified, out of which (52.33%) were prescribing errors, (41.66%) were administration errors, (4.66%) were monitoring errors and (1.33%) were dispensing errors. Incomplete prescriptions (55.41%), documentation errors (43.2%), omission errors (19.2%) and wrong time administration of medicine (13.6%) were the common types of medication errors. Of the total errors (80.33%), had the potential to cause harm, (16.33%) caused...
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Posted by admin on Nov 30, 2018 in |
The aim of the study was synthesis and characterization of 2-phenyl-1-benzopyran-4-one as a potential myeloperoxidase inhibitor. The oxidative stress was related to the generation of Reactive oxygen species (ROS), which is responsible for the enhancement of several degenerative diseases, such as osteoarthritis, cancer, diabetes, cardiovascular diseases, etc. Due to this fact, the study was targeted for the development of myeloperoxidase inhibitor for overcoming the oxidative stress. The molecular docking analysis were afforded that the titled compounds posses noteworthy potency against myeloperoxidase (PDB ID: 1DNU). The docking simulation of twenty hybrid of flavone showed the better binding score ranging between -6.66 to -8.56 kcal/mol. Based on the result, the synthesised compounds were screened for the evaluation of various in-vitro antioxidant studies. In which, the hydroxyl substituted flavones (HF1-HF8) were posses significant IC50 values compared with their respective standards due to their electron donating property over the radical responsible for oxidative stress. The docking score and in-vitro study of antioxidant activity were well correlated, which confirmed the antioxidant property of titled...
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Posted by admin on Nov 30, 2018 in |
Sickle cell anaemia is a genetic blood disorder that is caused by a mutation in the gene that encoded b-globin of haemoglobin, which results as the presence of abnormal haemoglobin HbS in the RBC. Presently, there is no universal cure for sickle cell anaemia Herbomineral formulations were standardized for organoleptic properties (colour, odour and taste), physiochemical properties, total ash value, moisture content, pH of the solution, to find effective agent in which we investigated the antisickling potential of T-AYU- HM Premium, a novel Herbomineral formulation. In-vitro sickling of homozygous sickle cells upon deoxygenation (Emmel’s Test) showed dose dependent inhibition of sickling in presence. T-AYU-H and T-AYU-HM Premium (25 µg/ml, 50 µg/ml, 100 µg/ml and 500 µg/ml). Mechanistic evaluations were performed such as, t-BOOH induced oxidative haemolysis, and formation of met-haemoglobin was significantly decreased in dose dependent manner in the presence of 50 µg/ml, 100 µg/ml and 500 µg/ml of T-AYU-H and T-AYU-HM Premium. Membrane stabilization activity by osmotic fragility test showed significant dose dependent increased stabilization in the presence...
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Posted by admin on Nov 30, 2018 in |
Ultraviolet radiation (UV) from sun has significant detoriating and degenerative effects on human skin and thus responsible for much skin disease. The most authentic and realistic approach to overcome this issue is to use or apply a barrier between sun rays and exposed skin surface using suitable products called sunscreens or UV protectors. Sunscreens usually include both natural and synthetic molecule and have great application in cosmaceuticals. In the present study one such natural product-rose water was evaluated for sun protecting ability of the rose water samples (SPF) using in-vitro spectroscopic method. A correlation was also established by evaluating the antioxidant activity in total 12 samples of rose water were evaluated for SPF and antioxidant activity Among all the samples the SPF value of sample #09 showed high sunscreen activity 3.956 followed by sample #08 with SPF value of 3.612. The rose water sample distilled in the lab indicated SPF value as 0.800. All the samples showed antioxidant activity (free radical scavenging ability). The phytochemical investigation indicates the presence...
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Posted by admin on Nov 30, 2018 in |
Antitumor and antioxidative efficacy of Carissa carandas extract (CCE) was investigated in this study against skin carcinogenesis which was initiated by a single topical application of 7, 12-dimethyl-benz(a)anthracene (100 mg / 100 ml acetone in 1% acetone) and two weeks, later promoted by repeated treatment of TPA (Croton oil) for 16 weeks (in 1% acetone) in Swiss albino mice. Oral administration of Carissa carandas hydroalcholic extract (100 mg/kg/b.wt/day) during the peri-initiational (i.e. 7 days before and 7 days after the application of DMBA) and post-initiational (i.e. from the day of croton oil treatment and continued till the end of the experiment) stage and exhibited a reduced number of tumor burden, tumor yield, number of tumors and percent incidence of mice bearing skin tumors as compared to DMBA-TPA treatment group. Average latent period and inhibition of tumor multiplicity were increased when compared to positive control values (only DMBA-TPA treated mice). After oral administration of CCE histopathological changes found less as compared to carcinogen treated mice in both the Groups. Thus,...
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