Posted by admin on Apr 30, 2024 in |
The increasing incidence of urolithiasis in the Asian population has been noted, and this condition can result in renal failure. The recurrent nature of stone formation presents a substantial apprehension, as it engenders iterative episodes of calculi development, culminating in gradual renal deterioration. Consequently, there exists a pressing imperative for comprehending the composition and etiological factors contributing to nephrolithiasis. A total of 14 kidney stone samples obtained from patients were subjected to X-ray diffraction (XRD), infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM) analysis. XRD analysis using MATCH software was employed to determine the crystallographic phases and quantitative abundances of different minerals. SEM examination was conducted to observe the microstructures of the kidney stones. Phase estimate findings showed that whewellite was the sole phase present in the Kidney Stone samples KS4, KS5, KS8, KS9, KS11, and KS12. Struvite and Hydroxyapatite were present in KS1, KS2, and KS13. Moreover, the study of KS3, KS6, and KS7 revealed varied levels of Struvite, Hydroxyapatite, and Weddellite. These microstructural features, investigated using the...
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Posted by admin on Apr 30, 2024 in |
Globally, cancer is a disease that is affecting the human population in abundance. According to the traditionally ayurvedic literature, Tinospora cordifolia are commonly applied in the treatment of various diseases. The present study was designed to investigate the antioxidant and anticancer activities of Tinospora cordifolia on the basis of its on biochemical and histopathological parameters. These included estimations of lipid peroxidation, CAT activity, GSH level, micronucleus assay and histopathological studies. In this study, phenolic and flavonoid content was found in leaves of Tinospora cordifolia. Cyclophosphamide (75 mg/kg; i.p.) is anticancer drug but it was used to induce dominant lethal mutation, micronuclei, DNA damage and generation of reactive oxygen species (ROS) in bone marrow for the estimation of antioxidant and anticancer activity. 5-Fluorouracil (30 mg/kg; i.p.) used as a standard, and ethanolic and aqueous extract of Tinospora cordifolia (250mg/kg, 500 mg/kg, 1000mg/kg; p.o.) is used as a preventive therapy. This study concluded that, both extract of T. cordifolia exerts antioxidant and anticancer...
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Posted by admin on Apr 30, 2024 in |
Background and Aim: Coconut sprouts, often referred to as coconut shoots or coconut hearts, have the potential to be analgesic and anti-inflammatory because of their abundance of phytochemicals, antioxidant capabilities, and traditional usage. In northeastern Brazil, herbal remedies made from coconut husk fiber are used to treat inflammatory diseases like arthritis. This study aimed to evaluate the analgesic and anti-inflammatory properties of coconut extract, Cocos nucifera L. Methods: Fresh coconut sprouts were collected, dried in the shade, grounded, and extracted using n-butanol. Phytochemical screening was carried out. The acute oral toxicity test was conducted by OECD Guidelines 423. Mice were chosen for analgesics study using Eddy’s hot plate method, whereas Swiss Albino rats were used for studies on acute inflammation using the carrageen an-induced rat paw edema model. Multiple comparison tests were run after a one-way ANOVA for statistical analysis. Results and Conclusion: The presence of tannins, flavonoids, and alkaloids, among other compounds, which are responsible for the anti-inflammatory and analgesic properties, is revealed by the phytochemical screening. The...
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Posted by admin on Apr 30, 2024 in |
A new HPLC method has been developed and validated for the simultaneous estimation of Rifampicin and Isoniazid, offering a reliable and efficient approach for their analysis. The method employs a mobile phase composed of pH 3.5 phosphate buffer, methanol, and water in a 45:30:25 ratio. It demonstrates a linear response for both drugs within specific concentration ranges, allowing for accurate quantification. Detection is performed at 239 nm, with retention times of 2.8 minutes for Rifampicin and 3.7 minutes for Isoniazid. Accuracy studies have shown excellent recovery rates within ICH guidelines, ensuring the reliability of the results. Notably, the method exhibits high precision with RSD values within acceptable limits, indicating its reproducibility. It has also been found to be simple, rapid, robust, and reproducible, making it well-suited for routine use. This validated HPLC method holds significant potential for both pharmaceutical and clinical applications, enabling accurate and efficient analysis of Rifampicin and Isoniazid in bulk and tablet dosage...
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Posted by admin on Mar 31, 2024 in |
Background: Fatigue is a common symptom in patients with advanced kidney disease, with implications for quality of life and clinical outcome. Fatigue is one of the most frequent complaints of dialysis patients and is associated with impaired health related quality of life (HRQOL). Aim: To monitor and measure the severity of fatigue in dialysis and non-dialysis patients of chronic kidney disease. Methodology: This prospective study was performed in the Department of Nephrology in SVIMS, Tirupati, over a period of 6 months. In this study, Fatigue Severity Scale was used with help of questionnaire form. Results: A total of 30 patients were recruited in this study based on their type of dialysis and we categorized subjects based on Gender, Age, Occupation, CKD Stage, dialysis per week, family history, complications and duration of CKD. We found that average fatigue score in Non-Dialysis subjects is 4.80±1.989, Hemodialysis subjects is 4.20±1.033, Peritoneal dialysis is 2.80±1.476. Conclusion: Our study concludes that patient having comorbidity condition like only Hypertension and Hypertension with Diabetes mellitus were...
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