Posted by admin on Jun 30, 2024 in |
Aim: Comparison of safety and efficacy in subtenon anesthesia versus peribulbar anesthesia in manual small incision cataract surgery by randomized control trial. Setting and design: A prospective observational study was conducted among 150 patients undergoing MSICS at a tertiary care hospital and was grouped into two groups peribulbar anesthesia and subtenon anesthesia. Material and Method: After randomization, 150 patients were assessed for various factors including pain at administration of anesthesia and pain during surgery. Result: A total of 150 patients were studied. The result shows no significant difference in pain during surgery and time of administration. Occurrences is chemosis and sub-conjunctival hemorrhage are more common in subtenon than in peribulbar anesthesia. Conclusion: Subtenon’s anesthesia is safe and effective as peribulbar anesthesia and is more comfortable for patients during...
Read More
Posted by admin on Jun 30, 2024 in |
Phytic acid and amylose in rice food play an essential role in human health. The best-practiced approach is necessary for nutritional quality improvement of rice grain. The mutational breeding approach and chemical treatment are powerful methods to enhance rice quality by managing the concentration of phytic acid and amylose contents. The analysis of glycemic index and amylose contents is also significant to reduce the risk of diseases. The present research investigates nutrient quality such as phytic acid and amylose content in the developed rice mutant (PBEF20). The developed mutant shows a 50% reduction in phytic acid with a 37.73% increment in amylose contents compared to the control i.e., untreated sample. The Inositol phosphate kinase (IPK-1) and ABC-2 type transporter domain-containing protein differentially downregulated in the early flowering mutant. IPK-1 gene is responsible for converting inositol 5-phosphate (IP5) to inositol 6-phosphate (IP6). The ABC-2 type genes are vacuolar transporters to transport the phosphate that assists in synthesizing phytic acid. The identified genes, including beta-amylase and chloroplast precursor, regulate various functions...
Read More
Posted by admin on Jun 30, 2024 in |
The medicinal plant Elaeocarpus serratus Linn., (Elaeocarpaceae) has been utilized in traditional medicine for various ailments. However, upon reviewing the literature, it was found that no anatomical work had been conducted on this plant. Therefore, our present study aimed to determine the macroscopic and microscopic characteristics of fresh leaf and stem of Elaeocarpus serratus. The macroscopic study is a technique of qualitative evaluation based on the study of morphological and sensory profiles. Externally, the leaves simple, alternate, spiral, clustered at twig ends, petiole 1.2- 4cm long and glabrous, lamina is elliptic with an acuminate or obtuse apex, base acute, serrate margin and glabrous and it appears red when senescent, midrib slightly raised above the surface. Inflorescences are in racemes, with white flower petals. The microscopic study is a qualitative evaluation technique used to confirm the structural details of drugs. Internally, the leaf exhibits both abaxial and adaxial epidermis, granular trichomes are unicellular, unbranched, wide and straight with pointed tip, cortex with tannin contents and calcium oxalate crystals. The petiole...
Read More
Posted by admin on Jun 30, 2024 in |
Background: Natural bioactive compounds of plant origin have attracted comprehensive attention due to their multiple biological effects, including antioxidant and immunomodulatory activities. However, scientific underpinnings of these health benefits are inadequate. Objective: Present investigation was undertaken to evaluate the bioavailability, antioxidant, and Immunomodulatory activity of the herbal formulation Lemon Peel extract (Storg-FA), which contains Lemon Peel extract standardized for 5% Folic Acid, along with co-nutrients including various water-soluble natural folates. Methods: The invitro antioxidant activity of Storg-FA was evaluated using the DPPH radical scavenging assay whereas cyclophosphamide induced immunosuppressed rat model was established to investigate the immunomodulatory activity of Storg-FA in Sprague-Dawley (SD) rats. Haemagglutination test was used to assess their effects on humoral response. After 14 and 21st days of drug administration, the extent of protection against immunosuppression caused by Cyclophosphamide was assessed by estimating hematological parameters. The invivo bioavailability study of Storg FA was conducted using LC-MS/MS analysis. Results: Storg-FA showed pronounced invitro antioxidant activity against DPPH radical. IC50 of Storg FA was found to be 109.35µg/ml,...
Read More
Posted by admin on Jun 30, 2024 in |
Background: Venous thromboembolism is the most common preventable cause of in-hospital mortality. Despite this, thromboprophylaxis practices vary related to order sets and special populations. Aim: To describe thromboprophylaxis strategies and awareness of institutional policies. Methods: Electronic survey of pharmacists having general medicine institutional practices within Alberta, Saskatchewan and Manitoba in 2017. Results: Amongst 88 (24.2%) respondents, the majority (60.2%) had practiced >5 years, and were working full time (81.8%) as staff pharmacists (94.3%). The majority (80.7%) used institutional order sets. In patients with normal weight and renal function, agents used were: dalteparin (36.4%), enoxaparin (31.1%), unfractionated heparin (UFH) (15.4%) and tinzaparin (11.3%), while for those with CrCl<30mL/min or hemodialysis, UFH (55.7% and 65.2%) and enoxaparin (23.5% and 26.3%) were used. Escalating doses for obesity were used by 86.7%, with upper weight extremes, defined in kilograms by 50.0% (median 100kg [range 100-150]), and BMI by 29.5% (median 40 [30-40]). Reduced doses were used for emaciation by 72.3%, with lower weight extremes defined in kilograms by 63.6% (median 40kg [30-50]). Prophylaxis...
Read More
